2015
ORBITOFRONTAL THICKNESS AS A MEASURE FOR TREATMENT RESPONSE PREDICTION IN OBSESSIVE–COMPULSIVE DISORDER
Hoexter M, Diniz J, Lopes A, Batistuzzo M, Shavitt R, Dougherty D, Duran F, Bressan R, Busatto G, Miguel E, Sato J. ORBITOFRONTAL THICKNESS AS A MEASURE FOR TREATMENT RESPONSE PREDICTION IN OBSESSIVE–COMPULSIVE DISORDER. Depression And Anxiety 2015, 32: 900-908. PMID: 26032588, DOI: 10.1002/da.22380.Peer-Reviewed Original ResearchConceptsTreatment-naïve OCD patientsObsessive-compulsive disorderTreatment responseIndependent cohortOCD patientsOFC thicknessRefractory OCD patientsTreatment-naïve patientsOrbitofrontal cortex thicknessSecond independent cohortLogistic regression modelsBaseline thicknessClinical trialsTreatment outcomesInitial cohortClinical utilityOrbitofrontal thicknessIneffective treatmentPatientsCohortMedial OFCNeuroimaging techniquesMorphometric biomarkersBiomarkersCortex thicknessVisuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive–Compulsive Disorder Patients
Batistuzzo M, Hoexter M, Taub A, Gentil A, Cesar R, Joaquim M, D'Alcante C, McLaughlin N, Canteras M, Shavitt R, Savage C, Greenberg B, Norén G, Miguel E, Lopes A. Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive–Compulsive Disorder Patients. Neuropsychopharmacology 2015, 40: 1837-1845. PMID: 25645373, PMCID: PMC4839507, DOI: 10.1038/npp.2015.33.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRefractory OCD patientsOCD patientsVisuospatial memory performanceComprehensive neuropsychological evaluationObsessive-compulsive disorder patientsTreatment-refractory obsessive-compulsive disorder patientsCognitive flexibilityNeuropsychological domainsMemory performanceVisuospatial learningNeuropsychological functioningVisuospatial perceptionIntellectual functioningInhibitory controlRefractory obsessive-compulsive disorderTreatment-refractory OCD patientsMemory improvementGamma ventral capsulotomyMotor functioningNeuropsychological evaluationNeuropsychological outcomesEffects of GVCMotor performanceFunctioning
2009
Treatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study
Lopes A, Greenberg B, Norén G, Canteras M, Busatto G, de Mathis M, Taub A, D'Alcante C, Hoexter M, Gouvea F, Cecconi J, Gentil A, Ferrão Y, Fuentes D, de Castro C, Leite C, Salvajoli J, Duran F, Rasmussen S, Miguel E. Treatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study. Journal Of Neuropsychiatry 2009, 21: 381-392. PMID: 19996246, DOI: 10.1176/jnp.2009.21.4.381.Peer-Reviewed Original ResearchConceptsResistant obsessive-compulsive disorderRefractory OCD patientsAdverse effectsPilot prospective studyObsessive-compulsive disorder patientsAdverse eventsProspective studyObsessive-compulsive disorderStereotactic radiosurgeryDepressive symptomsDisorder patientsSide effectsConventional treatmentCapsulotomyTherapeutic promisePatientsOCD patientsTreatmentSurgeryRadiosurgerySymptomsMonths
2008
Gamma ventral capsulotomy for treatment of resistant obsessive-compulsive disorder: A structural MRI pilot prospective study
Cecconi J, Lopes A, de Souza Duran F, Santos L, Hoexter M, Gentil A, Canteras M, de Castro C, Norén G, Greenberg B, Rauch S, Busatto G, Miguel E. Gamma ventral capsulotomy for treatment of resistant obsessive-compulsive disorder: A structural MRI pilot prospective study. Neuroscience Letters 2008, 447: 138-142. PMID: 18835422, DOI: 10.1016/j.neulet.2008.09.061.Peer-Reviewed Original ResearchConceptsGamma ventral capsulotomyObsessive-compulsive disorderRefractory obsessive-compulsive disorderResistant obsessive-compulsive disorderRefractory OCD patientsYear of radiosurgeryPilot prospective studyVoxel-based morphometry methodRegional structural abnormalitiesGray matter volumeRight inferior frontal gyrusInferior orbitofrontal cortexPostoperative increaseProspective studyInferior frontal gyrusMagnetic resonance imaging dataMatter volumeMRI scansNeurobiological changesStructural abnormalitiesOrbitofrontal cortexCapsulotomyPatientsOCD patientsFrontal gyrus