2024
Maternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach
Euclydes V, Braga C, Gouveia G, Martinez R, Camilo C, Simões S, Martins-Jr D, Fracolli L, Argeu A, Ferraro A, Matijasevich A, Fatori D, Miguel E, Polanczyk G, Brentani H. Maternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach. Brain Behavior & Immunity - Health 2024, 40: 100832. PMID: 39193418, PMCID: PMC11347843, DOI: 10.1016/j.bbih.2024.100832.Peer-Reviewed Original ResearchMaternal immune responseTrimester of pregnancyImmune responseNeurodevelopmental outcomesImmunological markersImmunological biomarkersMaternal childhood traumaNeurodevelopmental trajectoriesMother's immune responseEarly stages of pregnancyWeeks of pregnancyMaternal psychosocial stressStages of pregnancyStages of gestationRandomized clinical trialsAnti-inflammatory stateMaternal stress experienceNeurodevelopmental scoresImmune system responseInflammatory biomarkersClinical trialsPregnancyPsychosocial stress conditionBlood samplesLinear mixed-effects models
2021
Subcutaneous Ketamine in Depression: A Systematic Review
Cavenaghi V, da Costa L, Lacerda A, Hirata E, Miguel E, Fraguas R. Subcutaneous Ketamine in Depression: A Systematic Review. Frontiers In Psychiatry 2021, 12: 513068. PMID: 34122156, PMCID: PMC8193034, DOI: 10.3389/fpsyt.2021.513068.Peer-Reviewed Original ResearchRobust antidepressant effectsRacemic ketamineSystematic reviewAntidepressant effectsMultiple dosesDose-titration approachRandomized clinical trialsRisk of biasTransitory side effectsInclusion/exclusion criteriaPubMed/MEDLINESystematic literature searchWeb of ScienceSubcutaneous ketamineCochrane riskRemission rateBias toolRetrospective studyBeneficial efficacySC routeClinical trials
2014
Gamma Ventral Capsulotomy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial
Lopes A, Greenberg B, Canteras M, Batistuzzo M, Hoexter M, Gentil A, Pereira C, Joaquim M, de Mathis M, D’Alcante C, Taub A, de Castro D, Tokeshi L, Sampaio L, Leite C, Shavitt R, Diniz J, Busatto G, Norén G, Rasmussen S, Miguel E. Gamma Ventral Capsulotomy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial. JAMA Psychiatry 2014, 71: 1066-1076. PMID: 25054836, DOI: 10.1001/jamapsychiatry.2014.1193.Peer-Reviewed Original ResearchConceptsIntractable obsessive-compulsive disorderObsessive-compulsive disorderClinical trialsGamma ventral capsulotomyClinical Global Impressions-Improvement scaleSerious adverse eventsRandomized clinical trialsCGI-I ratingsDeep brain stimulationYale-Brown ObsessiveAdverse eventsMonth 12Additional patientsActive treatmentSham groupSymptom improvementInternal capsuleSpecialized centersNeurosurgical ablationAnterior limbMAIN OUTCOMEPsychiatric disordersPatientsOCD symptom improvementSelect cases