2021
Childhood poverty and mental health disorders in early adulthood: evidence from a Brazilian cohort study
Ziebold C, Evans-Lacko S, Andrade M, Hoffmann M, Fonseca L, Barbosa M, Pan P, Miguel E, Bressan R, Rohde L, Salum G, Schafer J, de Jesus Mari J, Gadelha A. Childhood poverty and mental health disorders in early adulthood: evidence from a Brazilian cohort study. European Child & Adolescent Psychiatry 2021, 32: 903-914. PMID: 34853911, DOI: 10.1007/s00787-021-01923-2.Peer-Reviewed Original ResearchConceptsMental health disordersStressful life eventsEarly adulthoodHealth disordersPreventable risk factorsDifferent stressful life eventsInternalizing disordersBrazilian cohort studyProspective community cohortWell-Being AssessmentCohort studyCommunity cohortRisk factorsStratified analysisPsychiatric diagnosisExternalizing disordersChildhood povertyDisordersBaselineAdulthoodStandardized classificationHigh exposureLife eventsAssociationYoung people
2020
Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents
Manfro A, Pine D, Polanczyk G, Santoro M, Smoller J, Koenen K, Mari J, Pan P, Zugman A, Schäfer J, Belangero S, Gosmann N, Simioni A, Hoexter M, Miguel E, Gadelha A, Rohde L, Salum G. Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1501-1512. PMID: 33346031, PMCID: PMC10259767, DOI: 10.1016/j.jaac.2020.11.016.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresPsychiatric diagnosisExecutive functionHigher schizophrenia polygenic risk scoresExecutive dysfunctionHigh Risk Cohort StudySmaller intracranial volumeHigher attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderSchizophrenia polygenic risk scoresCortical surface areaDichotomized ageCohort studyFunctional impairmentRisk scoreDomains of psychopathologyBrain regionsIntracranial volumeRelevant outcomesBrain structuresHyperactivity disorderCognitive tasksLatent class analysisLower chanceDiagnosis
2018
Diagnostic operationalization and phenomenological heterogeneity in psychiatry: the case of attention deficit hyperactivity disorder
Salum G, Gadelha A, Polanczyk G, Miguel E, Rohde L. Diagnostic operationalization and phenomenological heterogeneity in psychiatry: the case of attention deficit hyperactivity disorder. Salud Mental 2018, 41: 249-259. DOI: 10.17711/sm.0185-3325.2018.037.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderDeficit hyperactivity disorderHyperactivity disorderPhenomenological heterogeneityADHD symptomsTest-rest reliabilitySymptomatic thresholdSymptomatic scalesPathophysiological heterogeneityPsychiatric disordersPsychiatric diagnosisMental disordersSymptomsDiagnostic operationalizationsADHD diagnosisDisordersF168. PSYCHOTIC EXPERIENCE AND ADOLESCENT BRAIN TRAJECTORY: EVIDENCE FOR STRUCTURAL ALTERATIONS IN DOPAMINERGIC REGIONS
Zugman A, Gadelha A, Argolo F, Pan P, Rohde L, Miguel E, Bressan R, Jackowski A. F168. PSYCHOTIC EXPERIENCE AND ADOLESCENT BRAIN TRAJECTORY: EVIDENCE FOR STRUCTURAL ALTERATIONS IN DOPAMINERGIC REGIONS. Schizophrenia Bulletin 2018, 44: s286-s286. PMCID: PMC5888229, DOI: 10.1093/schbul/sby017.699.Peer-Reviewed Original ResearchCortical thickness measuresMental disordersCortical thicknessPsychotic experiencesSubcortical volumesLower subcortical volumesHigh-risk cohortCurrent psychiatric diagnosisPathogenesis of schizophreniaCurrent psychotic disorderAge interaction termMultiple comparisonsMulti-site longitudinal studyCommunity cohortDopaminergic neurotransmissionSubsequent riskDopaminergic imbalanceRight putamenBrain developmental trajectoriesMRI scansPsychiatric diagnosisPsychotic disordersBaseline assessmentCaudateAdolescent brain
2017
Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence
de Araujo C, Zugman A, Swardfager W, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, de Moura L, Del Aquilla M, Picon F, Amaro E, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence. Journal Of Psychiatric Research 2017, 98: 51-58. PMID: 29288952, DOI: 10.1016/j.jpsychires.2017.12.008.Peer-Reviewed Original ResearchConceptsPsychiatric disordersVal66Met polymorphismCortical thicknessBrain-derived neurotrophic factor (BDNF) Val66Met polymorphismRegional structural brain changesNeurotrophic factor Val66Met polymorphismPrefrontal cortexStructural brain changesLateral temporal cortexEffect of Val66MetBilateral prefrontal cortexVal66Met effectsWindow of vulnerabilityCortical maturationBrain changesOccipital lobeMet carriersAtypical neurodevelopmentMRI scansPsychiatric diagnosisTemporal cortexDiagnosis interactionVal66MetNeuropsychiatric disordersBrain morphologyThe Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children
Saad LO, do Rosario MC, Cesar RC, Batistuzzo MC, Hoexter MQ, Manfro GG, Shavitt RG, Leckman JF, Miguel EC, Alvarenga PG. The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 342-348. PMID: 28151703, PMCID: PMC5439443, DOI: 10.1089/cap.2016.0125.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsPsychiatric comorbidityPredictive valueBehavioral problemsDSM-IV psychiatric diagnosesPresence of OCSGroup of patientsHigh-risk cohortSignificant obsessive-compulsive symptomsNegative predictive valuePositive predictive valueHigh rateSeverity of OCSRisk cohortSchool-Aged ChildrenDepressive disorderFunctional impairmentPsychiatric diagnosisChild Behavior ChecklistComorbiditiesSevere psychopathologyBeing AssessmentScreening toolPediatric OCDAnxiety disorders
2016
Association of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage
Mansur R, Cunha G, Asevedo E, Zugman A, Rizzo L, Grassi-Oliveira R, Levandowski M, Gadelha A, Pan P, Teixeira A, McIntyre R, Mari J, Rohde L, Miguel E, Bressan R, Brietzke E. Association of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage. Psychoneuroendocrinology 2016, 71: 94-101. PMID: 27258821, DOI: 10.1016/j.psyneuen.2016.05.015.Peer-Reviewed Original ResearchConceptsParental mood disorderMental health problemsSerum interleukin-6Interleukin-6Perinatal complicationsEnvironmental risk factorsHealth problemsRisk factorsSerum levelsPsychiatric diagnosisParents' psychiatric diagnosisHigher serum levelsHigh Risk Cohort StudyMultiple risk factorsSocial disadvantageCohort studySystemic inflammationSocio-demographic characteristicsInflammatory activationMood disordersPsychiatric disordersDisorder pathogenesisComplicationsFamilial riskCumulative risk model
2015
Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample
Cunha G, Asevedo E, Mansur R, Zugman A, Pan P, Gadelha A, Belangero S, Rizzo L, Coelho R, Stertz L, Cogo-Moreira H, Grassi-Oliveira R, Teixeira A, Kauer-Sant'Anna M, Mari J, Miguel E, Bressan R, Brietzke E. Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample. Acta Psychiatrica Scandinavica 2015, 133: 122-132. PMID: 26139469, DOI: 10.1111/acps.12453.Peer-Reviewed Original ResearchCluster of symptomsChild Behavior ChecklistPsychiatric diagnosisBrain-derived neurotrophic factorLarge community sampleImmune-inflammatory pathwaysEotaxin/CCL11CBCL total scoreWell-Being AssessmentCommunity sampleSchool-based studyIllness severityPeripheral biomarkersIL-6Neurotrophic factorPeripheral bloodMCP-1Older subjectsBehavioral symptomsMental disordersSignificant associationNeurodevelopmental psychopathologySymptomsSpecific disordersTotal score
2013
2711 – Trajectory of comorbidity in obsessive-compulsive disorder
de Mathis A, Diniz J, Shavitt R, do Rosário M, Miguel E. 2711 – Trajectory of comorbidity in obsessive-compulsive disorder. European Psychiatry 2013, 28: 1. DOI: 10.1016/s0924-9338(13)77321-8.Peer-Reviewed Original ResearchComorbid psychiatric disordersFirst diagnosisPsychiatric disordersOCD patientsAnxiety disordersMain psychiatric diagnosisPost-traumatic stress disorderClinical manifestationsComorbid schizophreniaMean ageObsessive-compulsive disorderTic disordersSeparation anxiety disorderSomatoform disordersComorbid disordersPsychiatric diagnosisPanic disorderPatientsSubstance abuseSimple phobiaStress disorderHigh frequencyOCD outpatientsDiagnosisDisorders
2009
Higher prevalence of obsessive–compulsive spectrum disorders in rheumatic fever
de Alvarenga P, Floresi A, Torres A, Hounie A, Fossaluza V, Gentil A, Pereira C, Miguel E. Higher prevalence of obsessive–compulsive spectrum disorders in rheumatic fever. General Hospital Psychiatry 2009, 31: 178-180. PMID: 19269540, DOI: 10.1016/j.genhosppsych.2008.11.003.Peer-Reviewed Original ResearchConceptsRheumatic feverObsessive-compulsive spectrum disordersHigh prevalencePrevious historyPsychiatric outpatientsAnalytical cross-sectional studyConsecutive psychiatric outpatientsCross-sectional studySubclinical obsessive-compulsive disorderObsessive-compulsive disorderPositive historySpectrum disorderPsychiatric diagnosisMental disordersRelated disordersSenior psychiatristsObsessive-compulsive symptomsStatistical ManualDisordersPrevalencePrivate practiceFeverOutpatientsFourth EditionSuch history