2021
Lower Ventromedial Prefrontal Cortex Glutamate Levels in Patients With Obsessive–Compulsive Disorder
Batistuzzo M, Sottili B, Shavitt R, Lopes A, Cappi C, de Mathis M, Pastorello B, Diniz J, Silva R, Miguel E, Hoexter M, Otaduy M. Lower Ventromedial Prefrontal Cortex Glutamate Levels in Patients With Obsessive–Compulsive Disorder. Frontiers In Psychiatry 2021, 12: 668304. PMID: 34168581, PMCID: PMC8218991, DOI: 10.3389/fpsyt.2021.668304.Peer-Reviewed Original ResearchGamma-aminobutyric acidObsessive-compulsive disorderClinical symptomsHealthy controlsExcitatory/inhibitory imbalancePathophysiology of OCDGlu/Gln ratioH-MRS studiesGray matter fractionGlu/CrCortico-striatal circuitsGlutamate levelsExcitatory neurotransmissionNeurochemical imbalanceInhibitory imbalanceStriatal regionsUnderlying neurochemistryN-acetylaspartatePatientsKey neurotransmitterH-MRSVentromedial prefrontal cortexSecondary analysisAbnormal levelsPrefrontal cortex
2019
Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis
Lisboa B, Oliveira K, Tahira A, Barbosa A, Feltrin A, Gouveia G, Lima L, Feio dos Santos A, Martins D, Puga R, Moretto A, De Bragança Pereira C, Lafer B, Leite R, Ferretti-Rebustini R, Farfel J, Grinberg L, Jacob-Filho W, Miguel E, Hoexter M, Brentani H. Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis. Scientific Reports 2019, 9: 3086. PMID: 30816141, PMCID: PMC6395771, DOI: 10.1038/s41598-019-38965-1.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSynaptic transmissionPathophysiology of OCDDifferent striatal subregionsPostmortem brain tissueChemical synaptic transmissionStriatal areasCortico-striatoNeurotransmitter levelsStriatum regionThalamic circuitryStriatal subregionsSubregion specificityPsychiatric disordersPresynaptic processesSynaptic plasticityBrain samplesOCD pathophysiologyBrain tissueCSTC modelControl casesPathophysiologyRare variantsDisordersCellular responses
2015
Reduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding
Batistuzzo M, Balardin J, da Graça Morais Martin M, Hoexter M, Bernardes E, Borcato S, de Marco e Souza M, Querido C, Morais R, de Alvarenga P, Lopes A, Shavitt R, Savage C, Amaro E, Miguel E, Polanczyk G, Miotto E. Reduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding. Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 54: 849-858. PMID: 26407495, DOI: 10.1016/j.jaac.2015.06.020.Peer-Reviewed Original ResearchConceptsVerbal episodic memoryObsessive-compulsive disorderEpisodic memoryOrbitofrontal cortexPrefrontal cortexSemantic clusteringFunctional magnetic resonance imagingDorsomedial prefrontal cortexAltered brain activationDifferent neural mechanismsPathophysiology of OCDUnrelated wordsPrefrontal activationBrain activationWord listsExecutive dysfunctionNeural mechanismsTotal wordsCompulsive Scale scoresYale-Brown Obsessive Compulsive Scale scoresStrategy scoresStrategy applicationMemoryCortexKey regions
2014
An updated review of antidepressants with marked serotonergic effects in obsessive–compulsive disorder
Pizarro M, Fontenelle L, Paravidino D, Yücel M, Miguel E, de Menezes G. An updated review of antidepressants with marked serotonergic effects in obsessive–compulsive disorder. Expert Opinion On Pharmacotherapy 2014, 15: 1391-1401. PMID: 24766145, DOI: 10.1517/14656566.2014.914493.Peer-Reviewed Original ResearchConceptsDouble-blind studyObsessive-compulsive disorderPathophysiology of OCDEfficacy of desvenlafaxineEfficacy of antidepressantsShort-term treatmentOlder antidepressantsSerotonergic effectsClinical trialsSerotonergic systemNew agentsAntidepressantsSystematic reviewReliable efficacyEfficacyUpdated reviewClomipramineOCD symptomsDisordersTreatmentCurrent studyReviewSSRIsDuloxetineMirtazapine
2011
Gray Matter Volumes in Obsessive-Compulsive Disorder Before and After Fluoxetine or Cognitive-Behavior Therapy: A Randomized Clinical Trial
Hoexter M, de Souza Duran F, D'Alcante C, Dougherty D, Shavitt R, Lopes A, Diniz J, Deckersbach T, Batistuzzo M, Bressan R, Miguel E, Busatto G. Gray Matter Volumes in Obsessive-Compulsive Disorder Before and After Fluoxetine or Cognitive-Behavior Therapy: A Randomized Clinical Trial. Neuropsychopharmacology 2011, 37: 734-745. PMID: 22030709, PMCID: PMC3260985, DOI: 10.1038/npp.2011.250.Peer-Reviewed Original ResearchConceptsCognitive behavior therapyObsessive-compulsive disorderGray matter volumeLeft putamenClinical trialsOCD patientsGM volumeMatter volumeSignificant GM volume changesPathophysiology of OCDFluoxetine-treated patientsGM volume abnormalitiesMatched-healthy controlsTreatment-naive patientsFirst-line treatmentStructural brain abnormalitiesGM volume changesCBT-treated patientsGroup cognitive behavior therapySmaller GM volumeRegional brain volumesRegional brain morphologyAnterior cingulate cortexStructural magnetic resonanceRegional gray matter volume
2009
Association between symptom severity and internal capsule volume in obsessive-compulsive disorder
de Souza Duran F, Hoexter M, Valente A, Miguel E, Busatto G. Association between symptom severity and internal capsule volume in obsessive-compulsive disorder. Neuroscience Letters 2009, 452: 68-71. PMID: 19150484, DOI: 10.1016/j.neulet.2009.01.007.Peer-Reviewed Original ResearchConceptsWhite matter volumeObsessive-compulsive disorderMagnetic resonance imagingMatter volumeCingulum bundleWhite matter volume deficitsPathophysiology of OCDOCD patientsAsymptomatic control subjectsWhite matter reductionThalamic-cortical circuitWhite matter alterationsVoxel-based morphometryWhite matter tractsRegional white matter volumeSymptom severity ratingsInternal capsuleNeurosurgical treatmentSeverity scoreControl subjectsAnterior limbConnectivity dysfunctionT MRI scannerOCD severity scoresVolume deficits
2006
Tourette's Syndrome
Shavitt R, Hounie A, Campos M, Miguel E. Tourette's Syndrome. Psychiatric Clinics Of North America 2006, 29: 471-486. PMID: 16650718, DOI: 10.1016/j.psc.2006.02.005.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitorsReuptake inhibitorsLong-term side effect profileFirst-choice treatmentFirst-line optionSide effect profileCurrent treatment strategiesDorsolateral caudate nucleusPathophysiology of OCDExpression of TSTypical antipsychoticsAtypical antipsychoticsClinical manifestationsSomato-sensoryGenetic epidemiologic studiesGlobus pallidusTreatment strategiesEpidemiologic studiesCaudate nucleusTourette syndromePatient associationsRelated disordersBehavioral therapyPresence of TsSegregation analysis studies
2001
Regional Cerebral Blood Flow Abnormalities in Early-Onset Obsessive-Compulsive Disorder: An Exploratory SPECT Study
BUSATTO G, BUCHPIGUEL C, ZAMIGNANI D, GARRIDO G, GLABUS M, ROSARIO-CAMPOS M, CASTRO C, MAIA A, ROCHA E, MCGUIRE P, MIGUEL E. Regional Cerebral Blood Flow Abnormalities in Early-Onset Obsessive-Compulsive Disorder: An Exploratory SPECT Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 2001, 40: 347-354. PMID: 11288777, DOI: 10.1097/00004583-200103000-00015.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderLate-onset subjectsOCD subjectsRegional cerebral blood flow (rCBF) single-photon emissionCerebral blood flow single photon emissionRegional cerebral blood flow abnormalitiesCerebral blood flow abnormalitiesObsessive-compulsive symptomsPathophysiology of OCDBlood flow abnormalitiesEarly-onset casesOnset obsessive-compulsive disorderFrontal-subcortical circuitsAge of onsetEarly-onset subjectsAnterior cingulate cortexPrefrontal cortex relativeSingle photon emissionStatistical parametric mappingRCBF differencesRight thalamusHealthy controlsFlow abnormalitiesClinical dataCortex relative
2000
A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT)
Busatto G, Zamignani D, Buchpiguel C, Garrido G, Glabus M, Rocha E, Maia A, Rosario-Campos M, Castro C, Furuie S, Gutierrez M, McGuire P, Miguel E. A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT). Psychiatry Research 2000, 99: 15-27. PMID: 10891646, DOI: 10.1016/s0925-4927(00)00050-0.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexECD uptakeObsessive-compulsive disorderCingulate cortexLateral orbitofrontal cortexObsessive-compulsive symptomsOrbitofrontal cortexControl subjectsOCD patientsLeft dorsal anterior cingulate cortexRegional cerebral blood flow abnormalitiesImaging studiesCerebral blood flow abnormalitiesRight medial orbitofrontal cortexPatient samplesRegional cerebral blood flowPathophysiology of OCDRight lateral orbitofrontal cortexRCBF SPECT studiesHealthy control subjectsBlood flow abnormalitiesCerebral blood flowLarger patient samplesSmall patient sampleLeft lateral orbitofrontal cortex
1999
Relationship between obsessive-compulsive disorders and diseases affecting primarily the basal ganglia
Maia A, Barbosa E, Menezes P, Filho E. Relationship between obsessive-compulsive disorders and diseases affecting primarily the basal ganglia. Clinics 1999, 54: 213-221. PMID: 10881070, DOI: 10.1590/s0041-87811999000600008.Peer-Reviewed Original Research
1995
Transtorno obsessivo-compulsivo e os gânglios da base
Filho E. Transtorno obsessivo-compulsivo e os gânglios da base. Arquivos De Neuro-Psiquiatria 1995, 53: 858-859. PMID: 8729788, DOI: 10.1590/s0004-282x1995000500036.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderBasal gangliaCaudate nucleusPathophysiology of OCDSmaller caudate nucleusPrimary lesionCingulate cortexBrain structuresMagnetic resonance imagesCortexMental functionsPatientsGangliaMotor controlResonance imagesNucleus functionRecent studiesAdaptative responseThalamusPathophysiology