ORBITOFRONTAL THICKNESS AS A MEASURE FOR TREATMENT RESPONSE PREDICTION IN OBSESSIVE–COMPULSIVE DISORDER
Hoexter M, Diniz J, Lopes A, Batistuzzo M, Shavitt R, Dougherty D, Duran F, Bressan R, Busatto G, Miguel E, Sato J. ORBITOFRONTAL THICKNESS AS A MEASURE FOR TREATMENT RESPONSE PREDICTION IN OBSESSIVE–COMPULSIVE DISORDER. Depression And Anxiety 2015, 32: 900-908. PMID: 26032588, DOI: 10.1002/da.22380.Peer-Reviewed Original ResearchConceptsTreatment-naïve OCD patientsObsessive-compulsive disorderTreatment responseIndependent cohortOCD patientsOFC thicknessRefractory OCD patientsTreatment-naïve patientsOrbitofrontal cortex thicknessSecond independent cohortLogistic regression modelsBaseline thicknessClinical trialsTreatment outcomesInitial cohortClinical utilityOrbitofrontal thicknessIneffective treatmentPatientsCohortMedial OFCNeuroimaging techniquesMorphometric biomarkersBiomarkersCortex thickness