2012
Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive–compulsive disorder
Hoexter M, Dougherty D, Shavitt R, D'Alcante C, Duran F, Lopes A, Diniz J, Batistuzzo M, Evans K, Bressan R, Busatto G, Miguel E. Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive–compulsive disorder. European Neuropsychopharmacology 2012, 23: 569-580. PMID: 22841131, DOI: 10.1016/j.euroneuro.2012.06.014.Peer-Reviewed Original ResearchConceptsGray matter volumeMedial prefrontal cortexCognitive behavioral therapyObsessive-compulsive disorderTreatment responseTreatment-naïve OCD patientsTreatment groupsMagnetic resonance imagingMatter volumeOrbitofrontal cortexLateral orbitofrontal cortexSymptom improvementOCD patientsFluoxetine treatment groupTrial of fluoxetineSerotonin reuptake inhibitorsAdequate therapeutic approachStructural magnetic resonance imagingCBT treatment groupRight medial prefrontal cortexGroup-based cognitive behavioral therapyRegional gray matter volumeStructural MRI scansDistinct brain regionsYale-Brown Obsessive
2000
A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT)
Busatto G, Zamignani D, Buchpiguel C, Garrido G, Glabus M, Rocha E, Maia A, Rosario-Campos M, Castro C, Furuie S, Gutierrez M, McGuire P, Miguel E. A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT). Psychiatry Research 2000, 99: 15-27. PMID: 10891646, DOI: 10.1016/s0925-4927(00)00050-0.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexECD uptakeObsessive-compulsive disorderCingulate cortexLateral orbitofrontal cortexObsessive-compulsive symptomsOrbitofrontal cortexControl subjectsOCD patientsLeft dorsal anterior cingulate cortexRegional cerebral blood flow abnormalitiesImaging studiesCerebral blood flow abnormalitiesRight medial orbitofrontal cortexPatient samplesRegional cerebral blood flowPathophysiology of OCDRight lateral orbitofrontal cortexRCBF SPECT studiesHealthy control subjectsBlood flow abnormalitiesCerebral blood flowLarger patient samplesSmall patient sampleLeft lateral orbitofrontal cortex