Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents
Ota V, Santoro M, Spindola L, Pan P, Simabucuro A, Xavier G, Vieira-Fonseca T, Zanardo E, dos Santos F, Schäfer J, Kulikowski L, Galante P, Asprino P, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Gadelha A, Mari J, Bressan R, Salum G, Belangero S. Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents. Translational Psychiatry 2020, 10: 99. PMID: 32184383, PMCID: PMC7078305, DOI: 10.1038/s41398-020-0772-3.Peer-Reviewed Original ResearchConceptsPsychiatric symptomsMental disordersChild Behavior Checklist total scoresTrajectories of psychopathologyBlood gene expression profilesHigh Risk Cohort StudyGeneral psychiatric symptomsBlood gene expression patternsPsychopathological trajectoriesCohort studyLow-low groupLongitudinal cohortPostmortem brainsGeneral psychopathologySpecific disordersTotal scoreGene expressionCBCL scoresGene expression changesGene expression profilesDisordersSymptoms