2022
Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research
Shephard E, Batistuzzo M, Hoexter M, Stern E, Zuccolo P, Ogawa C, Silva R, Brunoni A, Costa D, Doretto V, Saraiva L, Cappi C, Shavitt R, Simpson H, van den Heuvel O, Miguel E. Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research. Brazilian Journal Of Psychiatry 2022, 44: 187-200. PMID: 35617698, PMCID: PMC9041967, DOI: 10.1590/1516-4446-2020-1709.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCourse of OCDCognitive mechanismsCommon psychiatric conditionsSpecific neurocircuitsCognitive functionNeurocognitive functionPsychiatric conditionsFuture researchComplexity of brainFuture directionsDisordersCurrent reviewNeuroscienceNeurocircuitsCompulsionResearchSymptomatologyObsessionExperiences of patientsExperienceImportant limitationsPresentationBetter understandingBrain
2021
Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder
Shephard E, Stern E, van den Heuvel O, Costa D, Batistuzzo M, Godoy P, Lopes A, Brunoni A, Hoexter M, Shavitt R, Reddy Y, Lochner C, Stein D, Simpson H, Miguel E. Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder. Molecular Psychiatry 2021, 26: 4583-4604. PMID: 33414496, PMCID: PMC8260628, DOI: 10.1038/s41380-020-01007-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCognitive neuroscienceNeurobiological alterationsMental health researchClinical profileFuture researchCase vignettesPsychiatric symptomsNeuromodulatory treatmentDifferent clinical profilesNeuroscienceEffective treatmentDisordersResearchBehavioralVignettesFindingsHealth researchTreatmentDysfunctionSymptomsPhenotypic expressionImportant limitationsTaxonomyPatients