2023
The association between duration of breastfeeding and the trajectory of brain development from childhood to young adulthood: an 8-year longitudinal study
Grevet L, Teixeira D, Pan P, Jackowski A, Zugman A, Miguel E, Rohde L, Salum G. The association between duration of breastfeeding and the trajectory of brain development from childhood to young adulthood: an 8-year longitudinal study. European Child & Adolescent Psychiatry 2023, 33: 1863-1873. PMID: 37650992, DOI: 10.1007/s00787-023-02283-9.Peer-Reviewed Original ResearchOverall cortical thicknessDuration of breastfeedingTotal intracranial volumeCortical thicknessBrain developmentIntracranial volumeLong-term health benefitsHealth benefitsHigh-risk cohortTotal brain volumeGlobal cortical thicknessStructural brain developmentMental health benefitsMultiple confoundersCortical areasMRI scansBrain areasBrain volumeBreastfeedingMRI T1Time pointsBrain measuresEarly adulthoodYoung adulthoodLongitudinal study
2022
Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder
Bertolín S, Alonso P, Martínez-Zalacaín I, Menchón J, Jimenez-Murcia S, Baker J, Bargalló N, Batistuzzo M, Boedhoe P, Brennan B, Feusner J, Fitzgerald K, Fontaine M, Hansen B, Hirano Y, Hoexter M, Huyser C, Jahanshad N, Jaspers-Fayer F, Kuno M, Kvale G, Lazaro L, Machado-Sousa M, Marsh R, Morgado P, Nakagawa A, Norman L, Nurmi E, O’Neill J, Ortiz A, Perriello C, Piacentini J, Picó-Pérez M, Shavitt R, Shimizu E, Simpson H, Stewart S, Thomopoulos S, Thorsen A, Walitza S, Wolters L, Group E, Real E, Segalas C, Morer A, Brem S, Ferreira S, Moreira P, Hagen K, Hamatani S, Takahashi J, Yoshida T, de Mathis M, Miguel E, Pariente J, Tang J, Thompson P, van den Heuvel O, Stein D, Soriano-Mas C. Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 62: 403-414. PMID: 36526161, PMCID: PMC10065927, DOI: 10.1016/j.jaac.2022.07.865.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyObsessive-compulsive disorderCBT responseCortical thicknessMagnetic Resonance Imaging PredictorsBaseline cortical thicknessPrefrontal cortex thicknessFirst-line treatmentRostral middle frontal gyrusPrefrontal cortical thicknessIdentification of predictorsHigher cortical thicknessMiddle frontal gyrusRight prefrontal cortexCortical surface areaMechanism of actionAdult patientsImaging predictorsPrefrontal cortex regionsClinical managementLarge seriesSubcortical volumesAdult populationFrontal polePrefrontal cortex
2019
Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence?
de Araujo C, Swardfager W, Zugman A, Cogo-Moreira H, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, Mansur R, Hoexter M, Picon F, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence? CNS Spectrums 2019, 25: 790-796. PMID: 31845634, DOI: 10.1017/s1092852919001688.Peer-Reviewed Original ResearchConceptsSerum BDNF concentrationsBrain-derived neurotrophic factorBDNF concentrationsBDNF genotypeCortical thicknessPsychiatric disordersSerum brain-derived neurotrophic factor (BDNF) concentrationsBrain-derived neurotrophic factor concentrationSubcortical volumesMental disordersWell-Being Behavior AssessmentBrain structuresBDNF serum concentrationsNeurotrophic factor concentrationsPeripheral blood concentrationsHigh Risk Cohort StudyLate childhoodAdult psychiatric disordersLarge independent samplesCohort studyNeurotrophic factorCortical maturationSerum concentrationsBlood concentrationsMet carriersMapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium
Kong XZ, Boedhoe PSW, Abe Y, Alonso P, Ameis SH, Arnold PD, Assogna F, Baker JT, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Brennan BP, Buitelaar J, Calvo R, Cheng Y, Cho KIK, Dallaspezia S, Denys D, Ely BA, Feusner J, Fitzgerald KD, Fouche JP, Fridgeirsson EA, Glahn DC, Gruner P, Gürsel DA, Hauser TU, Hirano Y, Hoexter MQ, Hu H, Huyser C, James A, Jaspers-Fayer F, Kathmann N, Kaufmann C, Koch K, Kuno M, Kvale G, Kwon JS, Lazaro L, Liu Y, Lochner C, Marques P, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Medland SE, Menchón JM, Minuzzi L, Moreira PS, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy JC, Nurmi EL, O'Neill J, Pariente JC, Perriello C, Piacentini J, Piras F, Piras F, Pittenger C, Reddy YCJ, Rus-Oswald OG, Sakai Y, Sato JR, Schmaal L, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Tolin DF, Tsuchiyagaito A, van Rooij D, van Wingen GA, Venkatasubramanian G, Wang Z, Yun JY, Group E, Kong X, Boedhoe P, Abe Y, Alonso P, Ameis S, Anticevic A, Arnold P, Assogna F, Baker J, Banaj N, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Bollettini I, Bose A, Brandeis D, Brem S, Brennan B, Buitelaar J, Busatto G, Calvo A, Calvo R, Cheng Y, Cho K, Ciullo V, Dallaspezia S, Denys D, de Vries F, de Wit S, Dickie E, Drechsler R, Ely B, Esteves M, Falini A, Fang Y, Feusner J, Figee M, Fitzgerald K, Fontaine M, Fouche J, Fridgeirsson E, Gruner P, Gürsel D, Hall G, Hamatani S, Hanna G, Hansen B, Hauser T, Hirano Y, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, James A, Jaspers-Fayer F, Kathmann N, Kaufmann C, Koch K, Kuno M, Kvale G, Kwon J, Lazaro L, Liu Y, Lochner C, Magalhães R, Marques P, Marsh R, Martínez-Zalacaín I, Masuda Y, Mataix-Cols D, Matsumoto K, McCracken J, Menchón J, Miguel E, Minuzzi L, Moreira P, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy J, Narumoto J, Nishida S, Nurmi E, O'Neill J, Pariente J, Perriello C, Piacentini J, Piras F, Piras F, Pittenger C, Poletti S, Reddy Y, Reess T, Rus-Oswald O, Sakai Y, Sato J, Schmaal L, Shimizu E, Simpson H, Soreni N, Soriano-Mas C, Sousa N, Spalletta G, Stern E, Stevens M, Stewart S, Szeszko P, Takahashi J, Tang J, Thorsen A, Tolin D, Tsuchiyagaito A, van Rooij D, van Wingen G, van der Werf Y, Veltman D, Vecchio D, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Xu J, Xu X, Yamada K, Yoshida T, Yun J, Zarei M, Zhao Q, Zhou C, Thompson P, Stein D, van den Heuvel O, Francks C, Thompson P, Stein D, van den Heuvel O, Francks C. Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium. Biological Psychiatry 2019, 87: 1022-1034. PMID: 31178097, PMCID: PMC7094802, DOI: 10.1016/j.biopsych.2019.04.022.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCase-control differencesBrain structural asymmetryMedication statusSubcortical structuresENIGMA consortiumSignificant case-control differencesRegional cortical thicknessPediatric obsessive-compulsive disorderPediatric datasetSubcortical asymmetriesDepression comorbidityCortical thicknessPotential associationLarger studyNeurodevelopmental processesVolume asymmetryBrain asymmetryAbnormal patternsDisordersPossible alterationsPutative linkOCD severityAsymmetry patternsMagnetic resonance
2018
F168. PSYCHOTIC EXPERIENCE AND ADOLESCENT BRAIN TRAJECTORY: EVIDENCE FOR STRUCTURAL ALTERATIONS IN DOPAMINERGIC REGIONS
Zugman A, Gadelha A, Argolo F, Pan P, Rohde L, Miguel E, Bressan R, Jackowski A. F168. PSYCHOTIC EXPERIENCE AND ADOLESCENT BRAIN TRAJECTORY: EVIDENCE FOR STRUCTURAL ALTERATIONS IN DOPAMINERGIC REGIONS. Schizophrenia Bulletin 2018, 44: s286-s286. PMCID: PMC5888229, DOI: 10.1093/schbul/sby017.699.Peer-Reviewed Original ResearchCortical thickness measuresMental disordersCortical thicknessPsychotic experiencesSubcortical volumesLower subcortical volumesHigh-risk cohortCurrent psychiatric diagnosisPathogenesis of schizophreniaCurrent psychotic disorderAge interaction termMultiple comparisonsMulti-site longitudinal studyCommunity cohortDopaminergic neurotransmissionSubsequent riskDopaminergic imbalanceRight putamenBrain developmental trajectoriesMRI scansPsychiatric diagnosisPsychotic disordersBaseline assessmentCaudateAdolescent brain
2017
Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence
de Araujo C, Zugman A, Swardfager W, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, de Moura L, Del Aquilla M, Picon F, Amaro E, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence. Journal Of Psychiatric Research 2017, 98: 51-58. PMID: 29288952, DOI: 10.1016/j.jpsychires.2017.12.008.Peer-Reviewed Original ResearchConceptsPsychiatric disordersVal66Met polymorphismCortical thicknessBrain-derived neurotrophic factor (BDNF) Val66Met polymorphismRegional structural brain changesNeurotrophic factor Val66Met polymorphismPrefrontal cortexStructural brain changesLateral temporal cortexEffect of Val66MetBilateral prefrontal cortexVal66Met effectsWindow of vulnerabilityCortical maturationBrain changesOccipital lobeMet carriersAtypical neurodevelopmentMRI scansPsychiatric diagnosisTemporal cortexDiagnosis interactionVal66MetNeuropsychiatric disordersBrain morphologyCortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group
Boedhoe PSW, Schmaal L, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Calvo R, Cheng Y, Cho KIK, Ciullo V, Dallaspezia S, Denys D, Feusner JD, Fitzgerald KD, Fouche JP, Fridgeirsson EA, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Jahanshad N, James A, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Morer A, Nakamae T, Nakao T, Narayanaswamy JC, Nishida S, Nurmi E, O’Neill J, Piacentini J, Piras F, Piras F, Reddy YCJ, Reess TJ, Sakai Y, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, van Wingen GA, Venkatasubramanian G, Walitza S, Wang Z, Yun JY, Thompson P, Stein D, van den Heuvel O, Boedhoe P, Schmaal L, Abe Y, Alonso P, Ameis S, Anticevic A, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Bollettini I, Bose A, Brandeis D, Brem S, Buimer E, Busatto G, Calvo A, Calvo R, Cheng Y, Cho K, Ciullo V, Dallaspezia S, de Vries F, de Wit S, Denys D, Drechsler R, Falini A, Fang Y, Feusner J, Figee M, Fitzgerald K, Fontaine M, Fouche J, Fridgeirsson E, Gruner P, Hanna G, Hauser T, Hibar D, Hoexter M, Hu H, Huyser C, Iorio M, Jahanshad N, James A, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, McCracken J, Menchón J, Miguel E, Minuzzi L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Narumoto J, Nishida S, Nurmi E, O’Neill J, Pariente J, Piacentini J, Pittenger C, Piras F, Piras F, Poletti S, Reddy Y, Reess T, Rus O, Sakai Y, Sato J, Simpson H, Soreni N, Soriano-Mas C, Spalletta G, Stevens M, Szeszko P, Tang J, Tolin D, van der Werf Y, van Wingen G, Vecchio D, Veltman D, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Xu J, Xu X, Yamada K, Yun J, Zarei M, Zhao Q, Thompson P, Stein D, van den Heuvel O. Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group. American Journal Of Psychiatry 2017, 175: 453-462. PMID: 29377733, PMCID: PMC7106947, DOI: 10.1176/appi.ajp.2017.17050485.Peer-Reviewed Original ResearchConceptsPediatric OCD patientsAdult OCD patientsOCD patientsParietal cortexAdult obsessive-compulsive disorderCortical thickness abnormalitiesD effectsInferior parietal cortexSuperior parietal cortexLimited statistical powerTransverse temporal cortexCohen's d effectClinical characteristicsCortical abnormalitiesObsessive-compulsive disorderThickness abnormalitiesHealthy controlsCortical thicknessPatientsTemporal cortexThinner cortexMRI scansClinical heterogeneityStructural abnormalitiesDisease profile
2016
Coordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation
Moura L, Crossley N, Zugman A, Pan P, Gadelha A, Del Aquilla M, Picon F, Anés M, Amaro E, de Jesus Mari J, Miguel E, Rohde L, Bressan R, McGuire P, Sato J, Jackowski A. Coordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation. Brain Imaging And Behavior 2016, 11: 808-817. PMID: 27169540, DOI: 10.1007/s11682-016-9555-0.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCortical thicknessDiffusion tensor imagingFractional anisotropyWhite matterBrain regionsStructural magnetic resonance imagingGray matter changesWhite matter tractsGray matter regionsCortical thinningMatter changesResonance imagingBrain developmentMatter regionsTensor imagingRespective tractsSignificant heterogeneityTractPrefrontal regionsAge 7Previous studiesBrain architectureAsynchronous maturation