2019
Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis
Lisboa B, Oliveira K, Tahira A, Barbosa A, Feltrin A, Gouveia G, Lima L, Feio dos Santos A, Martins D, Puga R, Moretto A, De Bragança Pereira C, Lafer B, Leite R, Ferretti-Rebustini R, Farfel J, Grinberg L, Jacob-Filho W, Miguel E, Hoexter M, Brentani H. Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis. Scientific Reports 2019, 9: 3086. PMID: 30816141, PMCID: PMC6395771, DOI: 10.1038/s41598-019-38965-1.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSynaptic transmissionPathophysiology of OCDDifferent striatal subregionsPostmortem brain tissueChemical synaptic transmissionStriatal areasCortico-striatoNeurotransmitter levelsStriatum regionThalamic circuitryStriatal subregionsSubregion specificityPsychiatric disordersPresynaptic processesSynaptic plasticityBrain samplesOCD pathophysiologyBrain tissueCSTC modelControl casesPathophysiologyRare variantsDisordersCellular responses
2018
Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive–compulsive disorder
de Oliveira K, Grinberg L, Hoexter M, Brentani H, Suemoto C, Nery F, Lima L, Alho A, Farfel J, Ferretti-Rebustini R, Leite R, Moretto A, da Silva A, Lafer B, Miguel E, Nitrini R, Jacob-Filho W, Heinsen H, Pasqualucci C. Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive–compulsive disorder. Brain Structure And Function 2018, 224: 191-203. PMID: 30298291, DOI: 10.1007/s00429-018-1752-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMedial orbitofrontalOrbitofrontal cortexNeuronal densityOCD casesLower neuron densityCortical-subcortical circuitryOFC abnormalitiesEfferent targetsNeuron densityClinical evaluationAnterolateral areaControl groupCognitive impairmentAutopsy serviceOrbitofrontal regionsAnteromedialOlder adultsControl casesOFC areasCortexConsistent evidenceDisordersCellular levelTotal