2020
Social losses predict a faster onset and greater severity of obsessive-compulsive disorder
Destrée L, Albertella L, Torres A, Ferrão Y, Shavitt R, Miguel E, Fontenelle L. Social losses predict a faster onset and greater severity of obsessive-compulsive disorder. Journal Of Psychiatric Research 2020, 130: 187-193. PMID: 32828024, DOI: 10.1016/j.jpsychires.2020.07.027.Peer-Reviewed Original ResearchConceptsClinical obsessive-compulsive disorderObsessive-compulsive disorderStressful life eventsSpeed of progressionYale-Brown ObsessiveDSM-IV Axis I DisordersLife eventsCompulsive ScaleAxis I DisordersStructured Clinical InterviewSeverity of symptomsSymptom dimensionsBeck Depression InventorySubclinical obsessive-compulsive symptomsBeck Anxiety InventorySpecific obsessive-compulsive symptom dimensionsI disordersFaster onsetPsychiatric disordersHistory questionnaireBrown AssessmentClinical InterviewGreater severityDepression InventoryObsessive-compulsive symptomsObsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD
Copetti M, Lopes A, Requena G, Johnson I, Greenberg B, Noren G, McLaughlin N, Shavitt R, Miguel E, Batistuzzo M, Hoexter M. Obsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD. Frontiers In Psychiatry 2020, 10: 936. PMID: 31998155, PMCID: PMC6962231, DOI: 10.3389/fpsyt.2019.00936.Peer-Reviewed Original ResearchGamma ventral capsulotomyPersonality disorder symptomsIntractable obsessive-compulsive disorderObsessive-compulsive disorderDisorder symptomsOCD patientsTreatment responseDisorder symptom changeSymptom changeStructured Clinical InterviewWorse treatment responseDSM-IV personality disordersWilcoxon signed-rank testPoorer ResponseClinical responseTreatment optionsInternal capsuleSigned-rank testTreatment attemptsAnterior limbClinical InterviewRadiosurgical proceduresPatientsSymptomsVentral part
2018
Dual diagnosis of obsessive compulsive and compulsive buying disorders: Demographic, clinical, and psychiatric correlates
Kim H, Hodgins D, Torres A, Fontenelle L, do Rosário M, de Mathis M, Ferrão Y, Miguel E, Tavares H. Dual diagnosis of obsessive compulsive and compulsive buying disorders: Demographic, clinical, and psychiatric correlates. Comprehensive Psychiatry 2018, 86: 67-73. PMID: 30081209, DOI: 10.1016/j.comppsych.2018.07.013.Peer-Reviewed Original ResearchConceptsCompulsive buying disorderObsessive-compulsive disorderBuying disorderComorbid obsessive-compulsive disorderDual diagnosisUnique clinical populationInternet use disordersDual diagnosis populationPsychiatric correlatesPsychiatric disordersPsychological mechanismsSocial phobiaOCD symptomsStructured Clinical InterviewClinical populationsSound measureLarge multi-centre studyClinical InterviewProtective factorsMulti-center studyUse disordersPresent researchTreatment utilityBinary logistic regressionCorrelates
2016
Serum copeptin in children exposed to maltreatment
Coelho R, Levandowski M, Mansur R, da Cunha G, Asevedo E, Zugman A, Salum G, Gadelha A, Pan P, Rizzo L, Manfro G, Mari J, Rohde L, Miguel E, Bressan R, Brietzke E, Grassi‐Oliveira R. Serum copeptin in children exposed to maltreatment. Psychiatry And Clinical Neurosciences 2016, 70: 434-441. PMID: 27278269, DOI: 10.1111/pcn.12412.Peer-Reviewed Original ResearchConceptsHistory of CMCopeptin levelsSerum copeptinChildhood maltreatmentChild Behavior ChecklistSerum copeptin levelsAdrenal axis activationSerum copeptin concentrationSevere childhood maltreatmentPromising new biomarkerCBCL total scoreEnzyme-linked immunosorbentExternalizing symptomsCopeptin concentrationsSerum levelsAxis activationPsychiatric morbidityPositive historyClinical InterviewCopeptinNew biomarkersHistory of abuseChild psychopathology symptomsSymptom severitySymptoms
2013
Symptom dimensions, clinical course and comorbidity in men and women with obsessive-compulsive disorder
Torresan R, Ramos-Cerqueira A, Shavitt R, do Rosário M, de Mathis M, Miguel E, Torres A. Symptom dimensions, clinical course and comorbidity in men and women with obsessive-compulsive disorder. Psychiatry Research 2013, 209: 186-195. PMID: 23298952, DOI: 10.1016/j.psychres.2012.12.006.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderClinical courseComorbid post-traumatic stress disorderDSM-IV Axis ICross-sectional studyStructured Clinical InterviewAlcohol use disorderSymptom dimensionsPost-traumatic stress disorderAdult OCD patientsBrazilian Research ConsortiumYale-Brown ObsessiveFemale patientsClinical presentationMean ageSymptom interferenceObsessive-compulsive spectrum disordersMajor depressionTic disordersFemale genderAxis IUse disordersClinical InterviewAnorexia nervosaSkin picking
2011
Skin picking and trichotillomania in adults with obsessive-compulsive disorder
Lovato L, Ferrão Y, Stein D, Shavitt R, Fontenelle L, Vivan A, Miguel E, Cordioli A. Skin picking and trichotillomania in adults with obsessive-compulsive disorder. Comprehensive Psychiatry 2011, 53: 562-568. PMID: 22014580, DOI: 10.1016/j.comppsych.2011.06.008.Peer-Reviewed Original ResearchConceptsPathologic skin pickingObsessive-compulsive disorderSkin pickingFourth Edition Axis IEdition Axis IStructured Clinical InterviewLogistic regression analysisComorbid body dysmorphic disorderBody dysmorphic disorderClinical characteristicsSuch comorbiditiesPrimary diagnosisAxis IClinical InterviewSpecific subgroupsMental disordersDysmorphic disorderStatistical ManualTrichotillomaniaDisordersCompulsive symptomsPatientsRegression analysisDiagnosisHigh levels
2010
Bipolar disorder and comorbid obsessive‐compulsive disorder is associated with higher rates of anxiety and impulse control disorders
Issler C, Monkul E, Amaral J, Tamada R, Shavitt R, Miguel E, Lafer B. Bipolar disorder and comorbid obsessive‐compulsive disorder is associated with higher rates of anxiety and impulse control disorders. Acta Neuropsychiatrica 2010, 22: 81-86. PMID: 25385033, DOI: 10.1111/j.1601-5215.2010.00457.x.Peer-Reviewed Original ResearchTreatment-emergent maniaObsessive-compulsive disorderFemale BD patientsComorbid obsessive-compulsive disorderBipolar disorderControl disordersResidual symptomsDepressive episodeBD patientsOCD patientsPrevious depressive episodesStructured Clinical InterviewHigh rateClinical characteristicsDisorder burdenChronic episodesFemale outpatientsTic disordersHigh riskComorbid disordersSevere formPatientsClinical InterviewSkin pickingDSM-IV
2009
Validation of the University of São Paulo Sensory Phenomena Scale:Initial Psychometric Properties
Rosario MC, Prado HS, Borcato S, Diniz JB, Shavitt RG, Hounie AG, Mathis ME, Mastrorosa RS, Velloso P, Perin EA, Fossaluza V, Pereira CA, Geller D, Leckman J, Miguel E. Validation of the University of São Paulo Sensory Phenomena Scale:Initial Psychometric Properties. CNS Spectrums 2009, 14: 315-323. PMID: 19668122, DOI: 10.1017/s1092852900020319.Peer-Reviewed Original ResearchConceptsOpen clinical interviewClinical InterviewYale-Brown ObsessiveObsessive-compulsive disorderFourth Edition Axis I DisordersEarly-onset OCD patientsYale Global Tic Severity ScaleSensory phenomenaCompulsive ScaleOCD patientsOCD subjectsAxis I DisordersTic Severity ScaleSão Paulo Sensory Phenomena ScaleSignificant differencesBeck Depression InventoryBeck Anxiety InventorySeverity scoreI disordersInter-rater reliabilityInitial psychometric propertiesSeverity ScalePremonitory urgesPatientsDepression InventoryObsessive-compulsive symptoms and disorder in patients with schizophrenia treated with clozapine or haloperidol
R. A, Hounie A, Sampaio A, Arrais J, Miguel E, Elkis H. Obsessive-compulsive symptoms and disorder in patients with schizophrenia treated with clozapine or haloperidol. Comprehensive Psychiatry 2009, 50: 437-442. PMID: 19683614, DOI: 10.1016/j.comppsych.2008.11.005.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsAntipsychotic AgentsClozapineComorbidityDiagnostic and Statistical Manual of Mental DisordersDrug Therapy, CombinationFemaleHaloperidolHumansInterview, PsychologicalMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesPsychometricsSchizophreniaYoung AdultConceptsObsessive-compulsive disorderObsessive-compulsive symptomsSchizophrenia patientsPrevalence of OCDSchizophrenia rating scalesPresence of OCSPrevalence of patientsUse of clozapineUse of antidepressantsClinical Global ImpressionPANSS total scoreCross-sectional studyStructured Clinical InterviewHigher severity scoresNegative Syndrome ScaleHigher severityYale-Brown ObsessiveGlobal ImpressionSeverity scorePatientsClozapineClinical InterviewHaloperidolSchizophrenia symptomsSyndrome Scale
2008
Obsessive–compulsive disorder: Influence of age at onset on comorbidity patterns
de Mathis M, do Rosario M, Diniz J, Torres A, Shavitt R, Ferrão Y, Fossaluza V, de Bragança Pereira C, Miguel E. Obsessive–compulsive disorder: Influence of age at onset on comorbidity patterns. European Psychiatry 2008, 23: 187-194. PMID: 18329252, DOI: 10.1016/j.eurpsy.2008.01.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAnxiety DisordersAttention Deficit Disorder with HyperactivityBrazilComorbidityCross-Sectional StudiesDisruptive, Impulse Control, and Conduct DisordersFeeding and Eating DisordersFemaleHumansMaleMental DisordersMiddle AgedObsessive-Compulsive DisorderPersonality AssessmentSex FactorsSomatoform DisordersTic DisordersConceptsImpulse control disordersInfluence of ageComorbidity patternsYale Global Tic Severity ScaleOCD patientsStructured Clinical InterviewTic Severity ScaleYale-Brown Obsessive Compulsive ScaleAttention-deficit/hyperactivity disorderObsessive Compulsive ScalePsychiatric comorbidityIllness durationTic disordersFemale genderSeverity ScaleClinical InterviewDSM-IVLower ageAnxiety disordersCompulsive ScaleHyperactivity disorderDisordersLower chanceAgeComorbidities
2007
Level of Insight and Clinical Features of Obsessive-Compulsive Disorder with and Without Body Dysmorphic Disorder
Nakata A, Diniz J, Torres A, de Mathis M, Fossaluza V, Bragancas C, Ferrão Y, Miguel E. Level of Insight and Clinical Features of Obsessive-Compulsive Disorder with and Without Body Dysmorphic Disorder. CNS Spectrums 2007, 12: 295-303. PMID: 17426667, DOI: 10.1017/s1092852900021052.Peer-Reviewed Original ResearchConceptsBody dysmorphic disorderClinical featuresObsessive-compulsive symptomsOCD patientsObsessive-compulsive disorderLevel of insightDysmorphic disorderPsychiatric comorbid disordersFourth Edition criteriaStructured Clinical InterviewComorbid body dysmorphic disorderLow educational levelEducational levelYale-Brown ObsessiveHigh morbidityPsychiatric comorbidityPossible confoundersEdition criteriaStudy groupComorbid disordersBrown AssessmentClinical InterviewPatientsBeck DepressionMental disorders
2005
Chronic tics and Tourette syndrome in patients with obsessive–compulsive disorder
Diniz J, Rosario-Campos M, Hounie A, Curi M, Shavitt R, Lopes A, Miguel E. Chronic tics and Tourette syndrome in patients with obsessive–compulsive disorder. Journal Of Psychiatric Research 2005, 40: 487-493. PMID: 16289552, DOI: 10.1016/j.jpsychires.2005.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChi-Square DistributionChildDiagnosis, DifferentialDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMiddle AgedMultivariate AnalysisObsessive-Compulsive DisorderPersonality InventoryPsychiatric Status Rating ScalesPsychometricsRetrospective StudiesSeverity of Illness IndexTic DisordersTourette SyndromeConceptsObsessive-compulsive disorderTourette syndromeOCD patientsVocal ticsYale Global Tic Severity ScaleNumber of comorbiditiesStructured Clinical InterviewTic Severity ScaleYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleSymptom onsetChronic motorTic disordersCommon disorderSeverity ScalePatientsClinical InterviewChronic ticsDSM-IVBehaviors InterviewCompulsive ScaleSomatic obsessionsDisordersCompulsive disorderOCD phenotypeClinical expression of obsessive-compulsive disorder in women with bipolar disorder
Issler C, de Mello Siqueira Amaral J, Tamada R, Schwartzmann A, Shavitt R, Miguel E, Lafer B. Clinical expression of obsessive-compulsive disorder in women with bipolar disorder. Brazilian Journal Of Psychiatry 2005, 27: 139-142. PMID: 15962140, DOI: 10.1590/s1516-44462005000200013.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderBipolar disorderRating ScaleObsessive-compulsive symptomsEarly onsetHamilton Depression Rating ScaleYoung Mania Rating ScaleNon-controlled designComorbid bipolar disorderSensory phenomenaDepression Rating ScaleStructured Clinical InterviewSeverity of symptomsMania Rating ScaleBipolar disorder ICompulsive Rating ScaleYale-Brown ObsessiveChronic motorManic episodesTic disordersVocal ticsClinical expressionClinical InterviewPsychopathological featuresDisorder I
2004
Impact of age at onset and duration of illness on the expression of comorbidities in obsessive-compulsive disorder.
Diniz J, Rosario-Campos M, Shavitt R, Curi M, Hounie A, Brotto S, Miguel E. Impact of age at onset and duration of illness on the expression of comorbidities in obsessive-compulsive disorder. The Journal Of Clinical Psychiatry 2004, 65: 22-7. PMID: 14744164, DOI: 10.4088/jcp.v65n0104.Peer-Reviewed Original ResearchConceptsDuration of illnessDepressive disorderTic disordersObsessive-compulsive symptomsExpression of comorbiditiesCommon etiologic pathwayLonger illness durationStructured Clinical InterviewDSM-IV criteriaObsessive-compulsive disorder patientsImpact of ageBody dysmorphic disorderConsecutive outpatientsSecondary complicationsObsessive-compulsive disorderPsychiatric comorbidityIllness durationEtiologic pathwaysDisorder patientsClinical InterviewComorbid diagnosesComorbiditiesIllnessAnxiety disordersDysmorphic disorder