2024
GPT-based normative models of brain sMRI correlate with dimensional psychopathology
Mendes S, Pinaya W, Pan P, Gadelha A, Belangero S, Jackowski A, Rohde L, Miguel E, Sato J. GPT-based normative models of brain sMRI correlate with dimensional psychopathology. Imaging Neuroscience 2024, 2: 1-15. DOI: 10.1162/imag_a_00204.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderChild Behavior ChecklistDeficit hyperactivity disorderAutism spectrum disorderPsychiatric disordersBrain regionsStructural MRIDimensional psychopathologyHyperactivity disorderBrazilian High-Risk Cohort StudyAttention deficit hyperactivity disorder scoresAutism Brain Imaging Data Exchange IIAdolescent Brain Cognitive DevelopmentChild Behavior Checklist scalesHigh Risk Cohort StudyDetect psychiatric symptomsEmergent psychiatric disordersBrain structural MRINeurobiological substratesNeuroimaging studiesLanguage tasksPsychiatric symptomsBehavior ChecklistPsychiatric conditionsSpectrum disorder
2023
An Evaluation of Item Harmonization Strategies Between Assessment Tools of Psychopathology in Children and Adolescents
Hoffmann M, Moore T, Axelrud L, Tottenham N, Pan P, Miguel E, Rohde L, Milham M, Satterthwaite T, Salum G. An Evaluation of Item Harmonization Strategies Between Assessment Tools of Psychopathology in Children and Adolescents. Assessment 2023, 31: 502-517. PMID: 37042304, DOI: 10.1177/10731911231163136.Peer-Reviewed Original Research
2022
Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes
Borges M, Hoffmann M, Simioni A, Axelrud L, Teixeira D, Zugman A, Jackowski A, Pan P, Bressan R, Parker N, Germann J, Bado P, Satterthwaite T, Milham M, Chakravarty M, Rohde L, Miguel E, Paus T, Salum G. Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes. Psychological Medicine 2022, 53: 5698-5708. PMID: 36226568, DOI: 10.1017/s0033291722002926.Peer-Reviewed Original ResearchConceptsExecutive functionTypical developmentInhibitory controlAcademic achievementCerebellar volumeHigher executive functionChild Behavior ChecklistTypical brain developmentSchool achievementBehavior ChecklistMental health conditionsStandardized measuresMediation analysisMental healthHigh Risk Cohort StudyEducational outcomesPsychopathologyBrain developmentMental conditionLongitudinal analysisYouthSpecific factorsAchievementCognitionAdolescenceThreat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents
Schäfer J, McLaughlin K, Manfro G, Pan P, Rohde L, Miguel E, Simioni A, Hoffmann M, Salum G. Threat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents. Developmental Science 2022, 26: e13267. PMID: 35417607, PMCID: PMC10028496, DOI: 10.1111/desc.13267.Peer-Reviewed Original ResearchConceptsChild Behavior ChecklistExecutive functionEmotional processingChildhood adversityBrazilian High-Risk CohortForms of adversityPoor developmental outcomesAttention biasAngry facesCognitive tasksCognitive developmentDevelopmental correlatesBehavior ChecklistChild developmentDevelopmental outcomesLongitudinal associationsGeneral psychopathologyPsychopathologyAdversityLatent constructsDifferential associationsWorse performanceDistinct aspectsCognitionMeaningful influence
2021
Association Between Obsessive-Compulsive Symptom Dimensions in Mothers and Psychopathology in Their Children
Blanco-Vieira T, Hoexter M, Batistuzzo M, Alvarenga P, Szejko N, Fumo A, Miguel E, do Rosário M. Association Between Obsessive-Compulsive Symptom Dimensions in Mothers and Psychopathology in Their Children. Frontiers In Psychiatry 2021, 12: 674261. PMID: 34262490, PMCID: PMC8273307, DOI: 10.3389/fpsyt.2021.674261.Peer-Reviewed Original ResearchPresence of OCSObsessive-compulsive symptomsChild Behavior ChecklistMini-International Psychiatric InterviewPsychopathology statusSymptom dimensionsBehavioral problemsNon-clinical presentationsYale-Brown ObsessiveAggression/violenceClinical variablesOverall prevalenceSchool-aged childrenPsychiatric interviewMaternal psychopathologyMother-child dyadsDimensional Yale-Brown ObsessiveSubscale scoresOwn psychopathologyMothersBehavior ChecklistMultiple regression analysisSignificant correlationRegression analysis
2019
SA72 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS
Spindola L, Santoro M, Pan P, Talarico F, Xavier G, Carvalho C, Gadelha A, Salum G, Miguel E, Rohde L, Zanardo E, Kulikowski L, Bressan R, Ota V, Belangero S. SA72 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2019, 29: s861. DOI: 10.1016/j.euroneuro.2017.08.144.Peer-Reviewed Original ResearchHigh-risk cohortPsychiatric disordersHealthy controlsGene expression profilingChild Behavior ChecklistEarly-onset psychiatric disordersBlood of adolescentsPrevious psychiatric disorderBlood gene expression profilingCross-sectional studyOnset psychiatric disordersWell-Being AssessmentAttention deficit hyperactivity disorderMost psychiatric disordersCanonical pathwaysSchool-based studyLarge public healthExpression profilingDeficit hyperactivity disorderRisk cohortPrevalent diagnosisPD groupMajor depressionHC groupMultiple comparison correctionSU73 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS
Spindola L, Santoro M, Pan P, Talarico F, Xavier G, Carvalho C, Gadelha A, Salum G, Miguel E, Rohde L, Zanardo E, Kulikowski L, Bressan R, Ota V, Belangero S. SU73 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2019, 29: s927-s928. DOI: 10.1016/j.euroneuro.2017.08.262.Peer-Reviewed Original ResearchHigh-risk cohortPsychiatric disordersHealthy controlsGene expression profilingChild Behavior ChecklistEarly-onset psychiatric disordersBlood of adolescentsPrevious psychiatric disorderBlood gene expression profilingCross-sectional studyOnset psychiatric disordersWell-Being AssessmentAttention deficit hyperactivity disorderMost psychiatric disordersCanonical pathwaysSchool-based studyLarge public healthExpression profilingDeficit hyperactivity disorderRisk cohortPrevalent diagnosisPD groupMajor depressionHC groupMultiple comparison correction
2017
The Social Aptitudes Scale: looking at both “ends” of the social functioning dimension
Axelrud L, DeSousa D, Manfro G, Pan P, Knackfuss A, Mari J, Miguel E, Rohde L, Salum G. The Social Aptitudes Scale: looking at both “ends” of the social functioning dimension. Social Psychiatry And Psychiatric Epidemiology 2017, 52: 1031-1040. PMID: 28567593, DOI: 10.1007/s00127-017-1395-8.Peer-Reviewed Original ResearchConceptsSocial aptitudeSocial functioningChild Behavior ChecklistSocial problemsAtypical developmentItem response theoryBehavior ChecklistHuman behaviorDimensional assessmentDistinct aspectsSocial functioning dimensionsFurther validityAptitudeResponse theoryFunctioningCaptures variabilityNon-significant correlationThe Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children
Saad LO, do Rosario MC, Cesar RC, Batistuzzo MC, Hoexter MQ, Manfro GG, Shavitt RG, Leckman JF, Miguel EC, Alvarenga PG. The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 342-348. PMID: 28151703, PMCID: PMC5439443, DOI: 10.1089/cap.2016.0125.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsPsychiatric comorbidityPredictive valueBehavioral problemsDSM-IV psychiatric diagnosesPresence of OCSGroup of patientsHigh-risk cohortSignificant obsessive-compulsive symptomsNegative predictive valuePositive predictive valueHigh rateSeverity of OCSRisk cohortSchool-Aged ChildrenDepressive disorderFunctional impairmentPsychiatric diagnosisChild Behavior ChecklistComorbiditiesSevere psychopathologyBeing AssessmentScreening toolPediatric OCDAnxiety disorders
2016
Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample
Mansur R, Cunha G, Asevedo E, Zugman A, Rios A, Salum G, Pan P, Gadelha A, Levandowski M, Belangero S, Manfro G, Stertz L, Kauer-Sant’anna M, Miguel E, Bressan R, Mari J, Grassi-Oliveira R, Brietzke E. Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample. European Child & Adolescent Psychiatry 2016, 26: 521-529. PMID: 27785581, DOI: 10.1007/s00787-016-0914-6.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrazilChecklistChildChild Behavior DisordersCohort StudiesDevelopmental DisabilitiesFemaleHumansLipid PeroxidationLong Term Adverse EffectsMaleMalondialdehydeMental DisordersMental HealthOxidative StressPregnancyPsychopathologySocioeconomic FactorsThiobarbituric Acid Reactive SubstancesConceptsPerinatal complicationsMental health problemsCumulative exposureLipid peroxidationTBARS levelsChild Behavior ChecklistHealth problemsHigh Risk Cohort StudyMini-International Psychiatric InterviewYears of ageCBCL total problemsIndividual cumulative exposureEarly life environmentCohort studyCumulative risk indexSerum levelsPerinatal historyUnexposed groupExploratory mediation analysisPsychiatric interviewComplicationsPsychiatric disordersSocio-economic statusPediatric samplesOxidative stressSerum copeptin in children exposed to maltreatment
Coelho R, Levandowski M, Mansur R, da Cunha G, Asevedo E, Zugman A, Salum G, Gadelha A, Pan P, Rizzo L, Manfro G, Mari J, Rohde L, Miguel E, Bressan R, Brietzke E, Grassi‐Oliveira R. Serum copeptin in children exposed to maltreatment. Psychiatry And Clinical Neurosciences 2016, 70: 434-441. PMID: 27278269, DOI: 10.1111/pcn.12412.Peer-Reviewed Original ResearchConceptsHistory of CMCopeptin levelsSerum copeptinChildhood maltreatmentChild Behavior ChecklistSerum copeptin levelsAdrenal axis activationSerum copeptin concentrationSevere childhood maltreatmentPromising new biomarkerCBCL total scoreEnzyme-linked immunosorbentExternalizing symptomsCopeptin concentrationsSerum levelsAxis activationPsychiatric morbidityPositive historyClinical InterviewCopeptinNew biomarkersHistory of abuseChild psychopathology symptomsSymptom severitySymptoms
2015
Temporal stability of network centrality in control and default mode networks: Specific associations with externalizing psychopathology in children and adolescents
Sato J, Biazoli C, Salum G, Gadelha A, Crossley N, Satterthwaite T, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Anés M, Moura L, Del'aquilla M, Amaro E, McGuire P, Lacerda A, Rohde L, Miguel E, Jackowski A, Bressan R. Temporal stability of network centrality in control and default mode networks: Specific associations with externalizing psychopathology in children and adolescents. Human Brain Mapping 2015, 36: 4926-4937. PMID: 26350757, PMCID: PMC6868942, DOI: 10.1002/hbm.22985.Peer-Reviewed Original ResearchConceptsDefault mode networkChild Behavior ChecklistDynamic functional connectivity patternsHigh Risk Cohort StudyBehavior ChecklistAbnormal connectivity patternsFunctional connectivity patternsResting-state fMRIPathological mental statesCohort studyConnectivity patternsPsychiatric disordersFunctional network dynamicsGeneral psychopathologyTotal scoreMode networkNetwork maturationBrain networksMaturation indexEmotional problemsChildrenAge effectsOverall presenceSpecific associationAdolescentsInflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample
Cunha G, Asevedo E, Mansur R, Zugman A, Pan P, Gadelha A, Belangero S, Rizzo L, Coelho R, Stertz L, Cogo-Moreira H, Grassi-Oliveira R, Teixeira A, Kauer-Sant'Anna M, Mari J, Miguel E, Bressan R, Brietzke E. Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample. Acta Psychiatrica Scandinavica 2015, 133: 122-132. PMID: 26139469, DOI: 10.1111/acps.12453.Peer-Reviewed Original ResearchCluster of symptomsChild Behavior ChecklistPsychiatric diagnosisBrain-derived neurotrophic factorLarge community sampleImmune-inflammatory pathwaysEotaxin/CCL11CBCL total scoreWell-Being AssessmentCommunity sampleSchool-based studyIllness severityPeripheral biomarkersIL-6Neurotrophic factorPeripheral bloodMCP-1Older subjectsBehavioral symptomsMental disordersSignificant associationNeurodevelopmental psychopathologySymptomsSpecific disordersTotal scoreDefault mode network maturation and psychopathology in children and adolescents
Sato J, Salum G, Gadelha A, Crossley N, Vieira G, Manfro G, Zugman A, Picon F, Pan P, Hoexter M, Anés M, Moura L, Del'Aquilla M, Amaro E, McGuire P, Lacerda A, Rohde L, Miguel E, Jackowski A, Bressan R. Default mode network maturation and psychopathology in children and adolescents. Journal Of Child Psychology And Psychiatry 2015, 57: 55-64. PMID: 26111611, DOI: 10.1111/jcpp.12444.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingChild Behavior ChecklistMental health disordersResting-state protocolPsychopathology scoresHealth disordersBehavior ChecklistDefault modeChild psychopathologyDeviant trajectoriesNeurodevelopmental trajectoriesAge of participantsBrain maturationLow-frequency fluctuationsPsychopathologyChronological ageFractional amplitudeMental disordersDMNGeneral psychopathology scoresNetwork maturationAge predictionChildrenPredictor variablesDisorders