2017
Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence
de Araujo C, Zugman A, Swardfager W, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, de Moura L, Del Aquilla M, Picon F, Amaro E, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence. Journal Of Psychiatric Research 2017, 98: 51-58. PMID: 29288952, DOI: 10.1016/j.jpsychires.2017.12.008.Peer-Reviewed Original ResearchConceptsPsychiatric disordersVal66Met polymorphismCortical thicknessBrain-derived neurotrophic factor (BDNF) Val66Met polymorphismRegional structural brain changesNeurotrophic factor Val66Met polymorphismPrefrontal cortexStructural brain changesLateral temporal cortexEffect of Val66MetBilateral prefrontal cortexVal66Met effectsWindow of vulnerabilityCortical maturationBrain changesOccipital lobeMet carriersAtypical neurodevelopmentMRI scansPsychiatric diagnosisTemporal cortexDiagnosis interactionVal66MetNeuropsychiatric disordersBrain morphology
2010
Effects of childhood development on late-life mental disorders
Salum G, Polanczyk G, Miguel E, Rohde L. Effects of childhood development on late-life mental disorders. Current Opinion In Psychiatry 2010, 23: 498-503. PMID: 20733493, DOI: 10.1097/yco.0b013e32833ead33.Peer-Reviewed Original ResearchConceptsLate-life mental disordersMental disordersCentral nervous systemEnvironmental risk factorsChildhood developmentMental health trajectoriesPreventive intervention strategiesRisk factorsAtypical neurodevelopmentNervous systemPreventive interventionsHomotypic continuityHealth trajectoriesIntervention strategiesDisordersPsychiatric phenotypesCurrent findingsRecent findingsChildhoodAdulthoodUrgent needFindings documentNeurodevelopmentFindings