2017
Molecular and Epigenetic Mechanisms for the Complex Effects of Stress on Synaptic Physiology and Cognitive Functions
Yuen EY, Wei J, Yan Z. Molecular and Epigenetic Mechanisms for the Complex Effects of Stress on Synaptic Physiology and Cognitive Functions. The International Journal Of Neuropsychopharmacology 2017, 20: 948-955. PMID: 29016816, PMCID: PMC5737802, DOI: 10.1093/ijnp/pyx052.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCognition DisordersEpigenesis, GeneticGlutamic AcidHumansStress, PsychologicalSynapsesSynaptic TransmissionConceptsEpigenetic mechanismsReceptor membrane traffickingStress-induced regulationSynaptic physiologyMembrane traffickingEpigenetic controlCytoskeleton networkGene expressionKey moleculesComplex effectsStress-related mental disordersPresynaptic glutamate releaseExcitatory synaptic transmissionStress-induced modulationPhysiologyGlutamatergic transmissionGlutamate releaseSynaptic transmissionBiphasic effectAnimal studiesComplex changesMental disordersBrain regionsChronic stressStress hormones
2015
The role of ventral striatal cAMP signaling in stress-induced behaviors
Plattner F, Hayashi K, Hernández A, Benavides DR, Tassin TC, Tan C, Day J, Fina MW, Yuen EY, Yan Z, Goldberg MS, Nairn AC, Greengard P, Nestler EJ, Taussig R, Nishi A, Houslay MD, Bibb JA. The role of ventral striatal cAMP signaling in stress-induced behaviors. Nature Neuroscience 2015, 18: 1094-1100. PMID: 26192746, PMCID: PMC4519694, DOI: 10.1038/nn.4066.Peer-Reviewed Original Research
2013
Restoration of Glutamatergic Transmission by Dopamine D4 Receptors in Stressed Animals*
Yuen EY, Zhong P, Li X, Wei J, Yan Z. Restoration of Glutamatergic Transmission by Dopamine D4 Receptors in Stressed Animals*. Journal Of Biological Chemistry 2013, 288: 26112-26120. PMID: 23884421, PMCID: PMC3764814, DOI: 10.1074/jbc.m112.396648.Peer-Reviewed Original ResearchConceptsD4 receptorsDopamine D4 receptorExcitatory transmissionGlutamatergic transmissionPrefrontal cortexAMPA receptor-mediated synaptic transmissionReceptor-mediated synaptic transmissionCalcium/calmodulin kinase II activityEffects of D4PFC pyramidal neuronsCalmodulin kinase II activityKey brain regionsAttention deficit hyperactivity disorderBi-directional regulationDeficit hyperactivity disorderPyramidal neuronsCortical excitabilityDopaminergic inputSynaptic actionsSynaptic transmissionPotent reductionAMPA receptorsKinase II activityStressed animalsMaladaptive changesEstrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition
Wei J, Yuen EY, Liu W, Li X, Zhong P, Karatsoreos IN, McEwen BS, Yan Z. Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition. Molecular Psychiatry 2013, 19: 588-598. PMID: 23835908, DOI: 10.1038/mp.2013.83.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAromataseAromatase InhibitorsCognitionEstradiolEstrogensFemaleGlutamic AcidMaleMemory DisordersPrefrontal CortexPyramidal CellsRats, Sprague-DawleyReceptors, EstrogenReceptors, GlutamateRecognition, PsychologyRNA, MessengerSex CharacteristicsStress, PsychologicalSynaptic TransmissionConceptsTemporal order recognition memoryGlutamatergic transmissionPrefrontal cortexStressed malesPFC of femalesNormal glutamatergic transmissionGlutamate receptor surface expressionPFC pyramidal neuronsYoung female ratsAdministration of estradiolLevels of aromatasePFC-dependent cognitionReceptor surface expressionBiosynthesis of estrogensEstrogen protectsPyramidal neuronsGlutamatergic deficitsRestraint stressFemale ratsEstrogen receptorGlutamate receptorsDetrimental effectsDimorphic effectsMemory impairmentStressed females
2012
Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex
Yuen EY, Wei J, Liu W, Zhong P, Li X, Yan Z. Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex. Neuron 2012, 73: 962-977. PMID: 22405206, PMCID: PMC3302010, DOI: 10.1016/j.neuron.2011.12.033.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerate6-Cyano-7-nitroquinoxaline-2,3-dioneAnalysis of VarianceAnimalsBicucullineCognition DisordersDisease Models, AnimalEndosomal Sorting Complexes Required for TransportExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsF-Box ProteinsGABA-A Receptor AntagonistsImmunoprecipitationIn Vitro TechniquesMaleNedd4 Ubiquitin Protein LigasesNeuropsychological TestsPrefrontal CortexPyramidal CellsRatsRats, Sprague-DawleyReceptors, GlutamateRecognition, PsychologyRestraint, PhysicalRNA, Small InterferingStress, PsychologicalUbiquitin-Protein LigasesConceptsGlutamate receptor expressionPrefrontal cortexRepeated stressReceptor expressionRecognition memoryCognitive processesTemporal order recognition memoryPFC pyramidal neuronsStress-related mental disordersJuvenile male ratsGlutamatergic responsesGlutamatergic transmissionPyramidal neuronsMale ratsSynaptic transmissionStressed animalsInhibition of proteasomeMaladaptive changesGlucocorticoid receptorCognitive impairmentNR1 subunitMental disordersChronic stressUbiquitin/proteasome-mediated degradationReceptor turnover
2010
Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory
Yuen EY, Liu W, Karatsoreos IN, Ren Y, Feng J, McEwen BS, Yan Z. Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory. Molecular Psychiatry 2010, 16: 156-170. PMID: 20458323, PMCID: PMC3108461, DOI: 10.1038/mp.2010.50.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBiophysicsCells, CulturedCorticosteroneDose-Response Relationship, DrugDrug InteractionsElectric StimulationExcitatory Amino Acid AgentsExcitatory Postsynaptic PotentialsGene Expression RegulationGlutamic AcidGreen Fluorescent ProteinsHormone AntagonistsImmediate-Early ProteinsIn Vitro TechniquesLong-Term PotentiationMaleMaze LearningMemory, Short-TermMifepristonePatch-Clamp TechniquesPeptidesPrefrontal CortexProtein Serine-Threonine KinasesPyramidal CellsRab GTP-Binding ProteinsRatsRats, Sprague-DawleyReceptors, GlutamateRNA, Small InterferingStress, PsychologicalSynaptic TransmissionTime FactorsTransfectionConceptsPrefrontal cortexGlutamatergic transmissionAcid receptorsPFC pyramidal neuronsAspartic acid (NMDA) receptorsIsoxazolepropionic acid (AMPA) receptorsInduction of serumCorticosteroid stress hormonesFunction of NMDARsStress-induced enhancementSustained potentiationPyramidal neuronsCorticosterone treatmentSynaptic responsesSynaptic transmissionBehavioral stressorsGlucocorticoid-inducible kinaseGlucocorticoid receptorAcute stressStress hormonesΑ-aminoSurface expressionReceptorsUnderlying mechanismReceptor recycling