Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats
Detloff MR, Fisher LC, McGaughy V, Longbrake EE, Popovich PG, Basso DM. Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats. Experimental Neurology 2008, 212: 337-347. PMID: 18511041, PMCID: PMC2600773, DOI: 10.1016/j.expneurol.2008.04.009.Peer-Reviewed Original ResearchConceptsPeripheral nerve injuryL5 dorsal hornRemote microglial activationLevel allodyniaPro-inflammatory cytokinesMicroglial activationNeuropathic painNerve injuryDorsal hornLevel painPro-inflammatory cytokine productionActivator of microgliaLevel neuropathic painRobust microglial activationChronic time pointsSpinal cord injuryLevel of injuryAllodynic ratsChronic allodyniaModerate SCISupraspinal centersCord injuryCytokine productionIL-6IL-1beta