2019
P573Effects of mobile text messaging on glycemic control in patients with coronary heart disease and diabetes mellitus: a randomized controlled trial
Huo X, Krumholz H, Bai X, Spatz E, Ding Q, Horak P, Zhao W, Gong Q, Yan X, Wu X, Li J, Li X, Spertus J, Masoudi F, Zheng X. P573Effects of mobile text messaging on glycemic control in patients with coronary heart disease and diabetes mellitus: a randomized controlled trial. European Heart Journal 2019, 40: ehz747.0184. DOI: 10.1093/eurheartj/ehz747.0184.Peer-Reviewed Original ResearchCoronary heart diseaseIntervention groupPhysical activityControl groupGlycemic controlHeart diseaseBaseline 6 monthsHigh-risk patientsText messaging programsSecondary outcome analysisMobile health interventionsText message programMean change differenceBP controlGlycemic hemoglobinHbA1c levelsLifestyle modificationUsual careDiabetes mellitusFamily Planning CommissionPrimary outcomeLifestyle recommendationsMonth followRisk factorsClinical trialsPrevalence, Awareness, and Treatment of Isolated Diastolic Hypertension: Insights From the China PEACE Million Persons Project
Mahajan S, Zhang D, He S, Lu Y, Gupta A, Spatz ES, Lu J, Huang C, Herrin J, Liu S, Yang J, Wu C, Cui J, Zhang Q, Li X, Nasir K, Zheng X, Krumholz HM, Li J, Dong Z, Jiang B, Zhang Y, Liu Y, Meng Y, Xi Y, Tian Y, Fu Y, Liu T, Yan S, Jin L, Wang J, Xu X, Xing X, Zhang L, Fang X, Xu Y, Xu C, Fan L, Qi M, Qi J, Li J, Liu Q, Feng Y, Wang J, Wen H, Xu J, He J, Jiang C, Yang C, Yu Y, Tashi Z, Hu Z, Zhang J, Li X, Ma S, Ma Y, Huang Y, Zhang Y, Shen J. Prevalence, Awareness, and Treatment of Isolated Diastolic Hypertension: Insights From the China PEACE Million Persons Project. Journal Of The American Heart Association 2019, 8: e012954. PMID: 31566101, PMCID: PMC6806046, DOI: 10.1161/jaha.119.012954.Peer-Reviewed Original ResearchConceptsMillion Persons ProjectPrior cardiovascular eventsBody mass indexAntihypertensive medicationsDiastolic hypertensionCardiovascular eventsDiabetes mellitusMass indexIsolated diastolic hypertensionDiastolic blood pressureSelf-reported diagnosisTreatment of peoplePersons ProjectBlood pressureTreatment patternsHypertensionLeast collegeHigher likelihoodMellitusMedicationsPrevalenceTreatmentDiagnosisSubstantial numberCurrent useEffects of Mobile Text Messaging on Glycemic Control in Patients With Coronary Heart Disease and Diabetes Mellitus
Huo X, Krumholz HM, Bai X, Spatz ES, Ding Q, Horak P, Zhao W, Gong Q, Zhang H, Yan X, Sun Y, Liu J, Wu X, Guan W, Wang X, Li J, Li X, Spertus JA, Masoudi FA, Zheng X. Effects of Mobile Text Messaging on Glycemic Control in Patients With Coronary Heart Disease and Diabetes Mellitus. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005805. PMID: 31474119, DOI: 10.1161/circoutcomes.119.005805.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsian PeopleBiomarkersBlood GlucoseChinaCoronary DiseaseCulturally Competent CareDiabetes MellitusExerciseFemaleGlycated HemoglobinHealth CommunicationHealthy LifestyleHumansHypoglycemic AgentsMaleMedication AdherenceMiddle AgedMotivationPatient Education as TopicRisk Reduction BehaviorSelf CareSingle-Blind MethodTelemedicineText MessagingTime FactorsTreatment OutcomeConceptsCoronary heart diseaseHeart diseaseGlycemic controlIntervention groupUsual careDiabetes mellitusBlood glucosePhysical activityControl groupText message-based interventionBlood pressure controlProportion of patientsRisk factor managementGood glycemic controlSystolic blood pressureBody mass indexText messaging programsText message interventionMobile health interventionsSecondary outcomesBlood pressurePrimary outcomeLDL cholesterolMass indexMedication adherenceAssociation of Diabetes Mellitus With Health Status Outcomes in Young Women and Men After Acute Myocardial Infarction: Results From the VIRGO Study
Ding Q, Funk M, Spatz ES, Whittemore R, Lin H, Lipska KJ, Dreyer RP, Spertus JA, Krumholz HM. Association of Diabetes Mellitus With Health Status Outcomes in Young Women and Men After Acute Myocardial Infarction: Results From the VIRGO Study. Journal Of The American Heart Association 2019, 8: e010988. PMID: 31441351, PMCID: PMC6755841, DOI: 10.1161/jaha.118.010988.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsDiabetes MellitusFemaleHealth StatusHealth Status IndicatorsHumansMaleMental HealthMiddle AgedMyocardial InfarctionPatient Reported Outcome MeasuresPredictive Value of TestsPrevalencePrognosisQuality of LifeRecovery of FunctionRisk AssessmentRisk FactorsSex FactorsSpainTime FactorsUnited StatesYoung AdultConceptsAcute myocardial infarctionEuroQol visual analogue scaleSeattle Angina QuestionnaireDiabetes mellitusForm Health SurveyHealth status outcomesHealth statusVIRGO StudyAnalog scaleMyocardial infarctionHealth SurveyStatus outcomesYoung adultsSAQ angina frequencyCardiovascular risk factorsHealth status scoresRisk of mortalityWorse health statusPoor health statusQuality of lifeWorse anginaAngina QuestionnaireClinical characteristicsHealthcare useStatus scoreEffect of Text Messaging on Risk Factor Management in Patients With Coronary Heart Disease
Zheng X, Spatz ES, Bai X, Huo X, Ding Q, Horak P, Wu X, Guan W, Chow CK, Yan X, Sun Y, Wang X, Zhang H, Liu J, Li J, Li X, Spertus JA, Masoudi FA, Krumholz HM. Effect of Text Messaging on Risk Factor Management in Patients With Coronary Heart Disease. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005616. PMID: 30998400, DOI: 10.1161/circoutcomes.119.005616.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsian PeopleBlood PressureChinaCoronary DiseaseCulturally Competent CareFemaleHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedPatient Education as TopicRisk AssessmentRisk FactorsSecondary PreventionSingle-Blind MethodTelemedicineText MessagingTime FactorsTreatment OutcomeConceptsCoronary heart diseaseSystolic blood pressureBody mass indexBlood pressureHeart diseaseSecondary preventionIntervention groupPhysical activityEnd pointSmoking statusMass indexControl groupPrimary end pointRisk factor controlSecondary end pointsRisk factor managementLDL-C levelsDisease-specific knowledgeMobile phone textMobile health technologyUsual careDiabetes mellitusMedication adherenceRisk factorsFactor managementSevere cardiovascular morbidity in women with hypertensive diseases during delivery hospitalization
Ackerman CM, Platner MH, Spatz ES, Illuzzi JL, Xu X, Campbell KH, Smith GN, Paidas MJ, Lipkind HS. Severe cardiovascular morbidity in women with hypertensive diseases during delivery hospitalization. American Journal Of Obstetrics And Gynecology 2019, 220: 582.e1-582.e11. PMID: 30742823, DOI: 10.1016/j.ajog.2019.02.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCardiomyopathiesCardiovascular DiseasesCerebrovascular DisordersCohort StudiesEclampsiaEducational StatusElectric CountershockEthnicityFemaleHeart ArrestHeart FailureHospitalizationHumansHypertension, Pregnancy-InducedInformation Storage and RetrievalInsurance, HealthLogistic ModelsMiddle AgedMultivariate AnalysisMyocardial InfarctionNew York CityObesity, MaternalPovertyPre-EclampsiaPregnancyRetrospective StudiesSeverity of Illness IndexVentricular FibrillationYoung AdultConceptsSevere cardiovascular morbidityCardiovascular morbidityDelivery hospitalizationsHypertensive disordersSevere featuresNormotensive womenGestational hypertensionCardiovascular diseaseRetrospective cohort studyClinical risk factorsPregnancy-related deathsMultivariable logistic regressionChronic hypertensionDiligent screeningSingleton gestationsCohort studyHypertensive diseaseDiabetes mellitusMaternal deathsRisk factorsInclusion criteriaDiseases-10HospitalizationMorbidityPreeclampsia
2018
Heart Failure After Ischemic Stroke or Transient Ischemic Attack in Insulin-Resistant Patients Without Diabetes Mellitus Treated With Pioglitazone
Young LH, Viscoli CM, Schwartz GG, Inzucchi SE, Curtis JP, Gorman MJ, Furie KL, Conwit R, Spatz E, Lovejoy A, Abbott JD, Jacoby DL, Kolansky DM, Ling FS, Pfau SE, Kernan WN. Heart Failure After Ischemic Stroke or Transient Ischemic Attack in Insulin-Resistant Patients Without Diabetes Mellitus Treated With Pioglitazone. Circulation 2018, 138: 1210-1220. PMID: 29934374, PMCID: PMC6202153, DOI: 10.1161/circulationaha.118.034763.Peer-Reviewed Original ResearchConceptsRisk of HFTransient ischemic attackEffect of pioglitazoneHF riskHeart failureInsulin-resistant patientsMyocardial infarctionIschemic attackCardiovascular benefitsIschemic strokeDiabetes mellitusInsulin resistanceHigher C-reactive proteinComposite of strokeHF risk scoreHigher HF riskDrug dose reductionHospitalized heart failureIncident myocardial infarctionLower mean doseC-reactive proteinBaseline patient featuresHF hospitalizationCardiovascular eventsPlacebo groupIs diabetes mellitus equivalent to atherosclerotic cardiovascular disease from a healthcare cost perspective? Insights from the Medical Expenditure Panel Survey
Feldman DI, Valero-Elizondo J, Salami JA, Rana JS, Ogunmoroti O, Okunrintemi V, Osondu CU, Spatz ES, Virani SS, Blankstein R, Blaha MJ, Veledar E, Nasir K. Is diabetes mellitus equivalent to atherosclerotic cardiovascular disease from a healthcare cost perspective? Insights from the Medical Expenditure Panel Survey. Cardiovascular Endocrinology & Metabolism 2018, 7: 64-67. PMID: 31646284, PMCID: PMC6739895, DOI: 10.1097/xce.0000000000000151.Peer-Reviewed Original ResearchAtherosclerotic cardiovascular diseaseDiabetes mellitusMedical Expenditure Panel SurveyCardiovascular diseaseMajor adverse cardiac eventsAggressive therapeutic managementAdverse cardiac eventsLower healthcare expendituresCardiac eventsSecondary preventionTherapeutic managementHealthcare costsEconomic burdenProper lifestyleHealthcare expendituresHousehold ComponentMellitusPanel SurveyDiseasePriority conditionsResource utilizationCliniciansDiagnosisIndividualsPreventionPresentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study
Safdar B, Spatz ES, Dreyer RP, Beltrame JF, Lichtman JH, Spertus JA, Reynolds HR, Geda M, Bueno H, Dziura JD, Krumholz HM, D'Onofrio G. Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study. Journal Of The American Heart Association 2018, 7: e009174. PMID: 29954744, PMCID: PMC6064896, DOI: 10.1161/jaha.118.009174.Peer-Reviewed Original ResearchConceptsMI-CAD patientsNonobstructive coronary arteriesMI-CADYounger patientsClinical profileCoronary arteryMyocardial infarctionTraditional cardiac risk factorsAcute myocardial infarction patientsCardiac risk factorsGestational diabetes mellitusMyocardial infarction patientsTimes higher oddsMINOCA patientsSAQ qualityVIRGO StudyClinical characteristicsHypercoaguable stateDiabetes mellitusObstructive diseaseClinical outcomesInfarction patientsRisk factorsMINOCAPsychosocial status
2017
Association Between Modifiable Risk Factors and Pharmaceutical Expenditures Among Adults With Atherosclerotic Cardiovascular Disease in the United States: 2012–2013 Medical Expenditures Panel Survey
Salami JA, Valero‐Elizondo J, Ogunmoroti O, Spatz ES, Rana JS, Virani SS, Blankstein R, Younus A, Arrieta A, Blaha MJ, Veledar E, Nasir K. Association Between Modifiable Risk Factors and Pharmaceutical Expenditures Among Adults With Atherosclerotic Cardiovascular Disease in the United States: 2012–2013 Medical Expenditures Panel Survey. Journal Of The American Heart Association 2017, 6: e004996. PMID: 28600400, PMCID: PMC5669151, DOI: 10.1161/jaha.116.004996.Peer-Reviewed Original ResearchConceptsModifiable risk factorsAtherosclerotic cardiovascular diseaseCardiovascular diseaseRisk factorsPharmaceutical expenditureMedication-related expendituresSignificant marginal increaseSurvey's complex designInadequate physical activityMedical Expenditure Panel SurveyMedical Expenditure PanelHigher healthcare spendingASCVD patientsDiabetes mellitusMost deathsPhysical activityTotal pharmaceutical expenditureAdjusted relationshipMedicationsDiseaseHealthcare spendingMellitusPatientsAssociationAdultsFavorable cardiovascular risk factor profile is associated with lower healthcare expenditure and resource utilization among adults with diabetes mellitus free of established cardiovascular disease: 2012 Medical Expenditure Panel Survey (MEPS)
Feldman DI, Valero-Elizondo J, Salami JA, Rana JS, Ogunmoroti O, Osondu CU, Spatz ES, Virani SS, Blankstein R, Blaha MJ, Veledar E, Nasir K. Favorable cardiovascular risk factor profile is associated with lower healthcare expenditure and resource utilization among adults with diabetes mellitus free of established cardiovascular disease: 2012 Medical Expenditure Panel Survey (MEPS). Atherosclerosis 2017, 258: 79-83. PMID: 28214425, DOI: 10.1016/j.atherosclerosis.2017.02.004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedCardiovascular DiseasesCost SavingsDiabetes ComplicationsDiabetes MellitusFemaleHealth Care CostsHealth Care SurveysHealth ExpendituresHealth ResourcesHumansLogistic ModelsMaleMiddle AgedModels, EconomicOdds RatioProcess Assessment, Health CareRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsFavorable cardiovascular risk factor profileCardiovascular risk factor profileRisk factor profileDiabetes mellitusMedical Expenditure Panel SurveyLower healthcare expendituresCardiovascular diseaseCRF profileDM statusHealthcare expendituresFactor profileCVD-free individualsMean annual expenditureLifestyle modificationMean ageIndividualized prescriptionTwo-part econometric modelEconomic burdenTherapeutic treatmentMellitusDiseaseCost dataAnnual expenditureIndividualsResource utilization
2016
Association Between a Prolonged PR Interval and Outcomes of Cardiac Resynchronization Therapy
Friedman DJ, Bao H, Spatz ES, Curtis JP, Daubert JP, Al-Khatib SM. Association Between a Prolonged PR Interval and Outcomes of Cardiac Resynchronization Therapy. Circulation 2016, 134: 1617-1628. PMID: 27760795, PMCID: PMC5418126, DOI: 10.1161/circulationaha.116.022913.Peer-Reviewed Original ResearchConceptsHeart failure hospitalizationFailure hospitalizationPR intervalImplantable cardioverter defibrillatorNational Cardiovascular Data Registry ICD RegistryCardiac resynchronization therapy candidatesIncident heart failure hospitalizationReal-world comparative effectivenessCRT-eligible patientsReceipt of CRTChronic kidney diseaseCardiac resynchronization therapyCRT-D patientsCoronary artery diseaseProlonged PR intervalComparative effectiveness analysisMore comorbiditiesArtery diseaseDiabetes mellitusICD recipientsICD RegistryResynchronization therapyAtrial arrhythmiasKidney diseaseCardioverter defibrillatorDiabetes Mellitus and Outcomes of Cardiac Resynchronization With Implantable Cardioverter-Defibrillator Therapy in Older Patients With Heart Failure
Echouffo-Tcheugui JB, Masoudi FA, Bao H, Spatz ES, Fonarow GC. Diabetes Mellitus and Outcomes of Cardiac Resynchronization With Implantable Cardioverter-Defibrillator Therapy in Older Patients With Heart Failure. Circulation Arrhythmia And Electrophysiology 2016, 9: e004132. PMID: 27489243, DOI: 10.1161/circep.116.004132.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyDevice-related complicationsDiabetes mellitusResynchronization therapyHeart failureHazard ratioOlder patientsHigh riskHeart failure-related readmissionsImplantable Cardioverter-Defibrillator RegistryImplantable cardioverter-defibrillator therapyNational Cardiovascular Data RegistryDiabetes mellitus statusCardioverter-defibrillator therapyCause readmissionMellitus statusDefibrillator implantationRenal failureProcedural complicationsCardiac resynchronizationDevice implantationQRS durationOdds ratioMellitusSimilar risk
2015
Geriatric Conditions in Patients Undergoing Defibrillator Implantation for Prevention of Sudden Cardiac Death
Green AR, Leff B, Wang Y, Spatz ES, Masoudi FA, Peterson PN, Daugherty SL, Matlock DD. Geriatric Conditions in Patients Undergoing Defibrillator Implantation for Prevention of Sudden Cardiac Death. Circulation Cardiovascular Quality And Outcomes 2015, 9: 23-30. PMID: 26715650, PMCID: PMC4759659, DOI: 10.1161/circoutcomes.115.002053.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCohort StudiesDeath, Sudden, CardiacDefibrillators, ImplantableDementiaDiabetes MellitusFemaleFrail ElderlyHeart FailureHumansLiver CirrhosisMaleNeoplasmsPrimary PreventionPulmonary Disease, Chronic ObstructiveRegistriesRenal Insufficiency, ChronicStrokeUnited StatesConceptsPrimary prevention ICDsPrevalence of frailtyICD implantationHeart failureGeriatric conditionsChronic conditionsMedicare patientsNational Cardiovascular Data Registry ICD RegistryPrimary prevention ICD implantationChronic obstructive pulmonary diseaseOne-year mortalityObstructive pulmonary diseaseCommon chronic conditionsSudden cardiac deathImpact of multimorbidityClaims-based algorithmLogistic regression modelsFrail patientsDefibrillator implantationOverall cohortPatient characteristicsCardiac deathDiabetes mellitusICD RegistryPulmonary disease