2024
Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study
Puklin L, Irwin M, Sanft T, Ferrucci L, Harrigan M, McGowan C, Cartmel B, Zupa M, Winer E, Deyling M, Ligibel J, Basen-Engquist K, Spiegelman D, Sharifi M. Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study. Supportive Care In Cancer 2024, 32: 590. PMID: 39141176, DOI: 10.1007/s00520-024-08789-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic AgentsBreast NeoplasmsExerciseFemaleHealth BehaviorHumansLife StyleMiddle AgedQualitative ResearchSurveys and QuestionnairesConceptsPhysical activityLifestyle interventionSelf-reported PA questionnaireSelf-reported diet qualityBreast cancerHealthy Eating Index-2015Stage I-III breast cancerBenefits of PASequential mixed methods studyI-III breast cancerChemotherapy-related symptomsMixed methods studyThematic content analysisBehavioral goalsSense of controlBody mass indexPA questionnaireSemi-structured interviewsMean body mass indexTranscribed verbatimIntervention armTailored educationDiet qualityNutritional behaviorMental benefits
2022
Breast Medical Oncologists' Perspectives of Telemedicine for Breast Cancer Care: A Survey Study
Stavrou E, Qiu J, Zafar A, Tramontano AC, Isakoff S, Winer E, Schrag D, Manz C. Breast Medical Oncologists' Perspectives of Telemedicine for Breast Cancer Care: A Survey Study. JCO Oncology Practice 2022, 18: e1447-e1453. PMID: 35671420, PMCID: PMC9509057, DOI: 10.1200/op.22.00072.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCOVID-19FemaleHumansOncologistsPandemicsSurveys and QuestionnairesTelemedicineUnited StatesConceptsBreast cancer careCancer carePercent of respondentsCancer CenterDana-Farber Cancer InstituteBreast cancer followMedical oncologist's perspectiveAcademic cancer centerPatient-physician communicationUse of telemedicineMost respondentsTM visitsCancer followRoutine followOncologist's perspectiveOncology visitsPatient adherenceOncology cliniciansClinicians' perceptionsFace visitsBreast cliniciansCancer InstituteSecond opinion consultationPatient carePatient recordsPerceptions of patients and medical oncologists toward biospecimen donation in the setting of abnormal breast imaging findings
Seah DS, Tayob N, Leone JP, Hu J, Yin J, Hughes M, Scott SM, Lederman RI, Frank E, Sohl JJ, Stadler ZK, Erick TK, Peppercorn J, Winer EP, Silverman SG, Come SE, Lin NU. Perceptions of patients and medical oncologists toward biospecimen donation in the setting of abnormal breast imaging findings. Breast Cancer Research And Treatment 2022, 192: 201-210. PMID: 35066788, DOI: 10.1007/s10549-021-06494-z.Peer-Reviewed Original ResearchConceptsAdditional biospecimensMedical oncologistsBreast biopsyBreast tissueBiopsy resultsSingle academic medical centerBreast medical oncologistsPain/discomfortPerceptions of patientsMost medical oncologistsAbnormal breastDiagnostic breast biopsyAcademic medical centerPercutaneous breast biopsyNational Cancer InstituteDonation of bloodCancer CenterDiagnostic biopsyPercutaneous biopsyMedical CenterBiopsyCancer InstitutePatientsOncologistsProcedure risk
2020
Perceptions of patients with early stage breast cancer toward research biopsies
Seah DS, Leone JP, Openshaw TH, Scott SM, Tayob N, Hu J, Lederman RI, Frank ES, Sohl JJ, Stadler ZK, Erick TK, Silverman SG, Peppercorn JM, Winer EP, Come SE, Lin NU. Perceptions of patients with early stage breast cancer toward research biopsies. Cancer 2020, 127: 1208-1219. PMID: 33320362, PMCID: PMC8247276, DOI: 10.1002/cncr.33371.Peer-Reviewed Original ResearchMeSH KeywordsAcademies and InstitutesAdultAgedAged, 80 and overAnalysis of VarianceAttitudeBiomedical ResearchBiopsyBlood DonorsBreastBreast NeoplasmsCancer Care FacilitiesFemaleHealth Services AccessibilityHumansMiddle AgedNeoplasm StagingSocioeconomic FactorsSurveys and QuestionnairesTissue and Organ ProcurementTissue DonorsConceptsEarly-stage breast cancerEarly breast cancerStage breast cancerResearch biopsiesBreast cancerMore patientsClinical trialsBreast biopsyMultivariate analysisProportion of patientsAcademic sitesCommunity oncology practicesPerceptions of patientsPerspectives of patientsCommunity-based sitesCommunity sitesMost patientsOncology sitesModifiable factorsPatients' willingnessUnivariate analysisOncology practiceBiopsyPatientsAcademic centersBarriers to Clinical Trial Accrual: Perspectives of Community-Based Providers
Knelson LP, Cukras AR, Savoie J, Agarwal A, Guo H, Hu J, Fell G, Lederman R, Hughes ME, Winer EP, Lin NU, Tolaney SM. Barriers to Clinical Trial Accrual: Perspectives of Community-Based Providers. Clinical Breast Cancer 2020, 20: 395-401.e3. PMID: 32605813, DOI: 10.1016/j.clbc.2020.05.001.Peer-Reviewed Original ResearchConceptsTrial participationTrial referralClinical trialsBreast cancerNurse practitioners/physician assistantsPatient-related barriersReferral of patientsClinical Trial AccrualCancer enrollMetastatic trialsReferral patternsSurgical oncologistsTrial awarenessReferral practicesTrial investigatorsBreast oncologyTrial knowledgePatientsPhysician assistantsTrial optionsMedical education coursesPatient interestReferralProvider perspectivesLogistical barriers
2017
Survival benefit needed to undergo chemotherapy: Patient and physician preferences
Vaz‐Luis I, O'Neill A, Sepucha K, Miller KD, Baker E, Dang CT, Northfelt DW, Winer EP, Sledge GW, Schneider B, Partridge AH. Survival benefit needed to undergo chemotherapy: Patient and physician preferences. Cancer 2017, 123: 2821-2828. PMID: 28323331, PMCID: PMC5517352, DOI: 10.1002/cncr.30671.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic Combined Chemotherapy ProtocolsAttitude of Health PersonnelAttitude to HealthBevacizumabBreast NeoplasmsChemotherapy, AdjuvantClinical Trials, Phase III as TopicCyclophosphamideDoxorubicinFemaleHumansMastectomyMastectomy, SegmentalMiddle AgedPaclitaxelPatient PreferencePhysiciansQuality of LifeRandomized Controlled Trials as TopicRisk AssessmentSurveys and QuestionnairesSurvival RateTumor BurdenConceptsMonths of chemotherapyModest survival benefitSurvival benefitAdjuvant chemotherapyEarly-stage breast cancerContemporary adjuvant chemotherapyPhase 3 trialBreast cancer patientsStage breast cancerQuality of lifeMonths of benefitsAdjuvant cyclophosphamideAdjuvant doxorubicinChemotherapy regimenMost patientsUndergoing ChemotherapyCancer patientsPatient preferencesBreast cancerModest benefitOld regimenChemotherapyPatientsPhysician's choiceSerial surveys
2015
Variation in the Attitudes of Medical Oncologists Toward Research Biopsies in Patients With Metastatic Breast Cancer
Seah DS, Scott S, Guo H, Najita J, Lederman R, Frank E, Sohl J, Stadler Z, Silverman S, Peppercorn J, Winer E, Come S, Lin NU. Variation in the Attitudes of Medical Oncologists Toward Research Biopsies in Patients With Metastatic Breast Cancer. The Oncologist 2015, 20: 992-1000. PMID: 26240134, PMCID: PMC4571800, DOI: 10.1634/theoncologist.2015-0112.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAttitude of Health PersonnelBiopsyBreast NeoplasmsFemaleHumansMedical OncologyMiddle AgedNeoplasm MetastasisPhysiciansSurveys and QuestionnairesConceptsMetastatic breast cancerBiopsy-related painResearch biopsiesMBC patientsMedical oncologistsOncologists' attitudesBreast cancerWillingness of patientsNational Cancer InstituteEligible respondersModifiable factorsAdditional biopsiesCancer CenterNCI centersPatients' willingnessCommon reasonBiopsyCancer InstitutePatientsSelf-administered surveyStandalone procedureTumor biologyAvailability of tissueElicit factorsPotential target
2014
Comorbidity, Chemotherapy Toxicity, and Outcomes Among Older Women Receiving Adjuvant Chemotherapy for Breast Cancer on a Clinical Trial: CALGB 49907 and CALGB 361004 (Alliance)
Klepin HD, Pitcher BN, Ballman KV, Kornblith AB, Hurria A, Winer EP, Hudis C, Cohen HJ, Muss HB, Kimmick GG. Comorbidity, Chemotherapy Toxicity, and Outcomes Among Older Women Receiving Adjuvant Chemotherapy for Breast Cancer on a Clinical Trial: CALGB 49907 and CALGB 361004 (Alliance). JCO Oncology Practice 2014, 10: e285-e292. PMID: 25074878, PMCID: PMC4161730, DOI: 10.1200/jop.2014.001388.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAntineoplastic AgentsBreast NeoplasmsCapecitabineChemotherapy, AdjuvantComorbidityDeoxycytidineDisease-Free SurvivalFemaleFluorouracilHumansKaplan-Meier EstimateMultivariate AnalysisProportional Hazards ModelsQuality of LifeRegression AnalysisSurveys and QuestionnairesTreatment OutcomeConceptsOverall survivalAdjuvant chemotherapyBurden scoreBreast cancerOlder womenShorter OSClinical trialsEarly-stage breast cancerCox proportional hazards modelStandard adjuvant chemotherapyNumber of comorbiditiesHazard of deathPhysical health subscaleOlder Americans ResourcesProportional hazards modelCALGB 49907Chemotherapy toxicityReceptor statusComorbid conditionsTumor sizeHealth subscaleGrade 3ComorbiditiesCommon conditionHazards modelAssociations among survivorship care plans, experiences of survivorship care, and functioning in older breast cancer survivors: CALGB/Alliance 369901
Faul LA, Luta G, Sheppard V, Isaacs C, Cohen HJ, Muss HB, Yung R, Clapp JD, Winer E, Hudis C, Tallarico M, Wang J, Barry WT, Mandelblatt JS. Associations among survivorship care plans, experiences of survivorship care, and functioning in older breast cancer survivors: CALGB/Alliance 369901. Journal Of Cancer Survivorship 2014, 8: 627-637. PMID: 24917307, PMCID: PMC4386650, DOI: 10.1007/s11764-014-0371-5.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBreast NeoplasmsCohort StudiesFemaleHumansLongitudinal StudiesSurveys and QuestionnairesSurvival RateSurvivorsTreatment OutcomeConceptsOlder breast cancer survivorsSurvivorship care plansBreast cancer survivorsCare plansCancer survivorsSCP receiptSurvivorship careOlder survivorsBreast cancer followCooperative group sitesNonmetastatic breast cancerPatient-reported outcomesCancer followSymptom burdenComorbid conditionsRecurrence surveillanceCancer patientsCancer sequelaePrimary careMethodsThree hundredBreast cancerCancer worryLower oddsOlder womenTelephone interviews
2013
Perceptions, knowledge, and satisfaction with contralateral prophylactic mastectomy among young women with breast cancer: a cross-sectional survey.
Rosenberg SM, Tracy MS, Meyer ME, Sepucha K, Gelber S, Hirshfield-Bartek J, Troyan S, Morrow M, Schapira L, Come SE, Winer EP, Partridge AH. Perceptions, knowledge, and satisfaction with contralateral prophylactic mastectomy among young women with breast cancer: a cross-sectional survey. Annals Of Internal Medicine 2013, 159: 373-81. PMID: 24042365, PMCID: PMC3968260, DOI: 10.7326/0003-4819-159-6-201309170-00003.Peer-Reviewed Original ResearchConceptsContralateral prophylactic mastectomyContralateral breast cancerBreast cancerCross-sectional surveyYoung womenProphylactic mastectomyBilateral breast cancerBreast cancer worryAge 40 yearsCommunity medical centerBRCA2 mutation carriersSusan G. KomenBilateral mastectomyUnaffected breastCancer worryMedical CenterMutation carriersMost womenCancerEvidence-based decisionsMastectomyRecall biasWomenRiskActual riskA planned, prospective comparison of short-term quality of life outcomes among older patients with breast cancer treated with standard chemotherapy in a randomized clinical trial vs. an observational study: CALGB #49907 and #369901
Mandelblatt JS, Makgoeng SB, Luta G, Hurria A, Kimmick G, Isaacs C, Tallarico M, Barry WT, Pitcher B, Winer EP, Hudis C, Cohen HJ, Muss HB. A planned, prospective comparison of short-term quality of life outcomes among older patients with breast cancer treated with standard chemotherapy in a randomized clinical trial vs. an observational study: CALGB #49907 and #369901. Journal Of Geriatric Oncology 2013, 4: 353-361. PMID: 24472479, PMCID: PMC3910230, DOI: 10.1016/j.jgo.2013.05.004.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overAnthracyclinesBreast NeoplasmsFemaleHumansQuality of LifeSurveys and QuestionnairesTreatment OutcomeConceptsRandomized clinical trialsOlder womenStandard chemotherapyClinical trialsProspective comparisonObservational studyBreast cancerNon-metastatic breast cancerOlder cancer populationPre-treatment QoLTherapy side effectsBreast cancer chemotherapyShort-term qualityAdjusted mean increaseQuality of lifeTumor factorsOlder patientsAnthracycline regimensQOL scoresGlobal QoLCancer populationSide effectsGroup physiciansChemotherapyLinear mixed effects modelsCognitive function in older women with breast cancer treated with standard chemotherapy and capecitabine on Cancer and Leukemia Group B 49907
Freedman RA, Pitcher B, Keating NL, Ballman KV, Mandelblatt J, Kornblith AB, Kimmick GG, Hurria A, Winer EP, Hudis CA, Cohen HJ, Muss HB, for the Alliance for Clinical Trials in Oncology. Cognitive function in older women with breast cancer treated with standard chemotherapy and capecitabine on Cancer and Leukemia Group B 49907. Breast Cancer Research And Treatment 2013, 139: 607-616. PMID: 23681403, PMCID: PMC3920483, DOI: 10.1007/s10549-013-2562-6.Peer-Reviewed Original ResearchConceptsSelf-reported cognitive functionCognitive function scoresCognitive functionOlder womenAdjuvant chemotherapyBreast cancerTime pointsStandard adjuvant chemotherapyAverage baseline scoreBaseline cognitive functionCALGB 49907Life substudyCognitive changesPerformance statusStandard chemotherapyMedian agePatient characteristicsTreatment armsTreatment regimenFunction scoresHealthy groupBaseline depressionCognitive screeningChemotherapyKruskal-Wallis testAttitudes of patients with metastatic breast cancer toward research biopsies
Seah DS, Scott SM, Najita J, Openshaw T, Krag K, Frank E, Sohl J, Stadler ZK, Garrett M, Silverman SG, Peppercorn J, Winer EP, Come SE, Lin NU. Attitudes of patients with metastatic breast cancer toward research biopsies. Annals Of Oncology 2013, 24: 1853-1859. PMID: 23493137, DOI: 10.1093/annonc/mdt067.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsyBreast NeoplasmsFemaleHumansMiddle AgedNeoplasm MetastasisPatient ParticipationSurveys and QuestionnairesPsychosexual Functioning and Body Image Following a Diagnosis of Ductal Carcinoma In Situ
Bober SL, Giobbie‐Hurder A, Emmons KM, Winer E, Partridge A. Psychosexual Functioning and Body Image Following a Diagnosis of Ductal Carcinoma In Situ. The Journal Of Sexual Medicine 2013, 10: 370-377. PMID: 22812628, DOI: 10.1111/j.1743-6109.2012.02852.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Agents, HormonalArousalBody ImageBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCohort StudiesCombined Modality TherapyDepressive DisorderFemaleFollow-Up StudiesHumansMassachusettsMastectomyMiddle AgedPersonal SatisfactionSexual BehaviorSurveys and QuestionnairesConceptsDiagnosis of DCISSexual functionHormonal therapyDuctal carcinomaPsychosexual functioningSexual functioningLarge-scale prospective studiesBody imageInvasive breast cancerProspective studyTreatment modalitiesTreatment optionsProspective surveySitu cancerBreast cancerDCISGeneral populationPsychosexual functionPatientsPsychosocial challengesDiagnosisTime pointsWomenMastectomySexual satisfaction
2012
Body image in recently diagnosed young women with early breast cancer
Rosenberg SM, Tamimi RM, Gelber S, Ruddy KJ, Kereakoglow S, Borges VF, Come SE, Schapira L, Winer EP, Partridge AH. Body image in recently diagnosed young women with early breast cancer. Psycho-Oncology 2012, 22: 1849-1855. PMID: 23132765, PMCID: PMC3594059, DOI: 10.1002/pon.3221.Peer-Reviewed Original ResearchConceptsCancer Rehabilitation Evaluation SystemMean CARE scoreCare scoresYoung womenBreast cancerMore body image concernsBody image concernsSurgical decision-making processMusculoskeletal pain symptomsProspective cohort studyEarly breast cancerBody imageWomen age 40Impact of treatmentImage concernsRehabilitation Evaluation SystemPotential future interventionsBreast cancer diagnosisMulti-variable analysisLumpectomy groupPain symptomsRadical surgeryCohort studySurgery typePsychological factorsModel Program to Improve Care for a Unique Cancer Population: Young Women With Breast Cancer
Partridge AH, Ruddy KJ, Kennedy J, Winer EP. Model Program to Improve Care for a Unique Cancer Population: Young Women With Breast Cancer. JCO Oncology Practice 2012, 8: e105-e110. PMID: 23277772, PMCID: PMC3439235, DOI: 10.1200/jop.2011.000501.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBreast NeoplasmsCohort StudiesFemaleFertility PreservationHumansPatient Education as TopicProspective StudiesQuality of LifeSurveys and QuestionnairesQuality of Life in Long-Term Survivors of Metastatic Breast Cancer
Meisel JL, Domchek SM, Vonderheide RH, Giobbie-Hurder A, Lin NU, Winer EP, Partridge AH. Quality of Life in Long-Term Survivors of Metastatic Breast Cancer. Clinical Breast Cancer 2012, 12: 119-126. PMID: 22444718, DOI: 10.1016/j.clbc.2012.01.010.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyBreast NeoplasmsCross-Sectional StudiesDepressionFemaleHumansMiddle AgedNeoplasm MetastasisQuality of LifeSurveys and QuestionnairesSurvivorsConceptsMetastatic breast cancerBreast cancerHormone receptor-positive diseaseNode-positive diseaseCancer Therapy-BreastLong-term survivorsSubset of womenHADS anxiety scoreHADS depression scorePopulation of womenFunctional Social Support QuestionnaireFisher's exact testQuality of lifeWilcoxon rank sum testCross-sectional surveyIES-R scaleRank sum testNorth Carolina Functional Social Support QuestionnaireAdjuvant therapyEligible womenPositive diseaseSpearman correlation coefficientDisease characteristicsHospital AnxietyMedical history
2011
Breast Cancer Survivors' Perceptions of Survivorship Care Options
Mayer EL, Gropper AB, Neville BA, Partridge AH, Cameron DB, Winer EP, Earle CC. Breast Cancer Survivors' Perceptions of Survivorship Care Options. Journal Of Clinical Oncology 2011, 30: 158-163. PMID: 22162585, PMCID: PMC4874208, DOI: 10.1200/jco.2011.36.9264.Peer-Reviewed Original ResearchConceptsPrimary care physiciansBreast cancer survivorsNurse practitionersCancer survivorsVirtual visitsClinician typeSurvivor careCancer survivalBreast cancer survivors increasesBreast cancer survivors' perceptionsBreast cancer-specific questionnaireCancer survivors increasesCancer-specific questionnaireCancer survivors' perceptionsSelf-perceived impactSurvivorship surveySurvivorship careMedical oncologistsCare physiciansPerson visitsSurvivors increasesClinic modelCare optionsVisitsCareQuality of Life of Older Patients With Early-Stage Breast Cancer Receiving Adjuvant Chemotherapy: A Companion Study to Cancer and Leukemia Group B 49907
Kornblith AB, Lan L, Archer L, Partridge A, Kimmick G, Hudis C, Winer E, Casey R, Bennett S, Cohen HJ, Muss HB. Quality of Life of Older Patients With Early-Stage Breast Cancer Receiving Adjuvant Chemotherapy: A Companion Study to Cancer and Leukemia Group B 49907. Journal Of Clinical Oncology 2011, 29: 1022-1028. PMID: 21300923, PMCID: PMC3068052, DOI: 10.1200/jco.2010.29.9859.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAntimetabolites, AntineoplasticAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCapecitabineChemotherapy, AdjuvantCyclophosphamideDeoxycytidineDisease-Free SurvivalDoxorubicinFemaleFluorouracilHumansMethotrexateNeoplasm StagingQuality of LifeRisk AssessmentRisk FactorsSurveys and QuestionnairesSurvival AnalysisTime FactorsTreatment OutcomeUnited StatesConceptsEarly-stage breast cancerSystemic adverse effectsStandard chemotherapyBreast cancerCapecitabine treatmentOlder patientsOverall survivalStandard treatmentBetter QOLAdverse effectsHand-foot syndromePhase III trialsLife Questionnaire C30Completion of treatmentQuality of lifeAdjuvant chemotherapyLife substudyIII trialsCancer QualityImproved survivalLess nauseaGood appetiteHospital AnxietyDepression ScaleMonths postbaseline
2010
Physical and Psychological Outcomes Among Women in a Telephone-Based Exercise Intervention During Adjuvant Therapy for Early Stage Breast Cancer
Ligibel JA, Partridge A, Giobbie-Hurder A, Campbell N, Shockro L, Salinardi T, Winer EP. Physical and Psychological Outcomes Among Women in a Telephone-Based Exercise Intervention During Adjuvant Therapy for Early Stage Breast Cancer. Journal Of Women's Health 2010, 19: 1553-1559. PMID: 20629579, DOI: 10.1089/jwh.2009.1760.Peer-Reviewed Original ResearchConceptsEarly-stage breast cancerStage breast cancerExercise interventionBreast cancerWeight gainAdjuvant therapyHome-based exercise interventionModerate-intensity aerobic exercise interventionSingle-arm pilot studyIntensive chemotherapy regimensAerobic exercise interventionBreast cancer patientsActivity/weekBreast cancer recurrenceBreast cancer diagnosisAdjuvant chemotherapyChemotherapy regimensPostoperative complicationsSedentary womenWeek 12Cancer outcomesPoor QoLCancer patientsCardiorespiratory fitnessWeekly exercise