2024
Helping ourselves, helping others: the Young Women’s Breast Cancer Study (YWS) – a multisite prospective cohort study to advance the understanding of breast cancer diagnosed in women aged 40 years and younger
Rosenberg S, Zheng Y, Ruddy K, Poorvu P, Snow C, Kirkner G, Meyer M, Tamimi R, Schapira L, Peppercorn J, Come S, Borges V, Warner E, Gelber S, Collins L, Winer E, Partridge A. Helping ourselves, helping others: the Young Women’s Breast Cancer Study (YWS) – a multisite prospective cohort study to advance the understanding of breast cancer diagnosed in women aged 40 years and younger. BMJ Open 2024, 14: e081157. PMID: 38951008, PMCID: PMC11218027, DOI: 10.1136/bmjopen-2023-081157.Peer-Reviewed Original ResearchConceptsYoung Women's Breast Cancer StudyMultisite prospective cohort studyBreast Cancer StudyProspective cohort studyStage 0-IV breast cancerBreast cancerCohort studyOlder womenDied of breast cancerFear of recurrencePatient-reported outcome dataYoung womenCancer studiesClinical data abstractionPost-traumatic stressQuality of lifeImprove careFollow-upPsychosocial outcomesYoung survivorsCommunity sitesBiospecimen collectionUnderstudied populationData abstractionOutcome data
2020
Response to neoadjuvant chemotherapy and the 21-gene Breast Recurrence Score test in young women with estrogen receptor-positive early breast cancer
Sella T, Gelber SI, Poorvu PD, Kim HJ, Dominici L, Guzman-Arocho YD, Collins L, Ruddy KJ, Tamimi RM, Peppercorn JM, Schapira L, Borges VF, Come SE, Warner E, Snow C, Jakubowski DM, Russell CA, Winer EP, Rosenberg SM, Partridge AH. Response to neoadjuvant chemotherapy and the 21-gene Breast Recurrence Score test in young women with estrogen receptor-positive early breast cancer. Breast Cancer Research And Treatment 2020, 186: 157-165. PMID: 33150547, DOI: 10.1007/s10549-020-05989-5.Peer-Reviewed Original ResearchConceptsRecurrence Score resultsNeoadjuvant chemotherapyPathological complete responseBreast cancerBreast Cancer StudyYoung womenEstrogen receptor-positive early breast cancerReceptor-positive early breast cancerYoung Women's Breast Cancer StudyHER2-negative breast cancerScore resultsEarly breast cancerLogistic regression modelingAdjuvant chemotherapyNeoadjuvant therapyProspective cohortComplete responseMedian ageMultivariable analysisRecurrence scoreVs. 5Clinical careTumor specimensStage IPatientsResponse to neoadjuvant chemotherapy and the 21-gene breast recurrence score in young women with estrogen receptor-positive early breast cancer.
Sella T, Gelber S, Poorvu P, Kim H, Guzman Arocho Y, Collins L, Ruddy K, Tamimi R, Peppercorn J, Schapira L, Borges V, Come S, Warner E, Snow C, Jakubowski D, Russell C, Winer E, Rosenberg S, Partridge A. Response to neoadjuvant chemotherapy and the 21-gene breast recurrence score in young women with estrogen receptor-positive early breast cancer. Journal Of Clinical Oncology 2020, 38: 514-514. DOI: 10.1200/jco.2020.38.15_suppl.514.Peer-Reviewed Original ResearchPathologic complete responseBreast Recurrence ScoreNeoadjuvant chemotherapyBreast cancerRecurrence scoreBreast Cancer StudyYoung womenHER2- BCEstrogen receptor-positive early breast cancerHER-2 negative breast cancerReceptor-positive early breast cancerYoung Women's Breast Cancer StudyNeoadjuvant endocrine therapyResidual invasive tumorEarly breast cancerPost-menopausal womenNegative breast cancerHigh gradeLogistic regression modelingAdjuvant chemotherapyDuctal histologyPgR negativityEndocrine therapyNeoadjuvant therapyProspective cohort
2019
Prognostic Impact of the 21-Gene Recurrence Score Assay Among Young Women With Node-Negative and Node-Positive ER-Positive/HER2-Negative Breast Cancer
Poorvu PD, Gelber SI, Rosenberg SM, Ruddy KJ, Tamimi RM, Collins LC, Peppercorn J, Schapira L, Borges VF, Come SE, Warner E, Jakubowski DM, Russell C, Winer EP, Partridge AH. Prognostic Impact of the 21-Gene Recurrence Score Assay Among Young Women With Node-Negative and Node-Positive ER-Positive/HER2-Negative Breast Cancer. Journal Of Clinical Oncology 2019, 38: 725-733. PMID: 31809240, PMCID: PMC7048163, DOI: 10.1200/jco.19.01959.Peer-Reviewed Original ResearchConceptsNode-positive breast cancerDistant recurrence-free survivalRecurrence scoreBreast cancerBreast Cancer StudyN0 diseaseN1 diseaseYoung womenYoung Women's Breast Cancer StudyPositive/HER2-negative breast cancerHER2-negative breast cancerHuman epidermal growth factor receptorEarly distant recurrenceEarly-stage estrogenN0 breast cancerRS risk groupsNode-positive diseaseMinority of patientsRecurrence-free survivalYears of ageEpidermal growth factor receptorGrowth factor receptorDistant recurrenceAxillary nodesEligible women
2016
Subtype-Dependent Relationship Between Young Age at Diagnosis and Breast Cancer Survival
Partridge AH, Hughes ME, Warner ET, Ottesen RA, Wong YN, Edge SB, Theriault RL, Blayney DW, Niland JC, Winer EP, Weeks JC, Tamimi RM. Subtype-Dependent Relationship Between Young Age at Diagnosis and Breast Cancer Survival. Journal Of Clinical Oncology 2016, 34: 3308-3314. PMID: 27480155, DOI: 10.1200/jco.2015.65.8013.Peer-Reviewed Original ResearchConceptsMultivariable Cox proportional hazards modelsCox proportional hazards modelBreast cancer deathsProportional hazards modelBreast cancerYears of ageYounger ageCancer deathHazards modelHuman epidermal growth factor receptor 2 subtypeStage INational Comprehensive Cancer Network centersBreast cancer-specific survivalEarly-stage breast cancerYoung womenCancer-specific survivalSurvival of womenEarly breast cancerLuminal B tumorsBreast cancer mortalityTriple-negative tumorsBreast cancer survivalLuminal breast cancerBreast cancer recurrenceBreast cancer subtypes
2015
Molecular Phenotype of Breast Cancer According to Time Since Last Pregnancy in a Large Cohort of Young Women
Collins LC, Gelber S, Marotti JD, White S, Ruddy K, Brachtel EF, Schapira L, Come SE, Borges VF, Schedin P, Warner E, Wensley T, Tamimi RM, Winer EP, Partridge AH. Molecular Phenotype of Breast Cancer According to Time Since Last Pregnancy in a Large Cohort of Young Women. The Oncologist 2015, 20: 713-718. PMID: 26025931, PMCID: PMC4492229, DOI: 10.1634/theoncologist.2014-0412.Peer-Reviewed Original ResearchConceptsBreast cancer molecular phenotypesBreast cancerYoung womenFamily historyPregnancy-associated breast cancerMolecular phenotypesTumor histologic gradeBreast cancer riskBreast cancer phenotypeLast pregnancyParous womenProspective cohortCentral reviewHistologic gradeLike subtypeMolecular subtypesLarge cohortCancer riskPregnancyClinical practiceStudy questionnaireBiomarker expressionCancerTumor phenotypeWomenOvarian function suppression, symptom burden, and quality of life in young women with breast cancer: A prospective study.
Rosenberg S, Ruddy K, Tamimi R, Gelber S, Schapira L, Borges V, Come S, Meyer M, Winer E, Partridge A. Ovarian function suppression, symptom burden, and quality of life in young women with breast cancer: A prospective study. Journal Of Clinical Oncology 2015, 33: 515-515. DOI: 10.1200/jco.2015.33.15_suppl.515.Peer-Reviewed Original ResearchLocal Therapy Decision-Making and Contralateral Prophylactic Mastectomy in Young Women with Early-Stage Breast Cancer
Rosenberg SM, Sepucha K, Ruddy KJ, Tamimi RM, Gelber S, Meyer ME, Schapira L, Come SE, Borges VF, Golshan M, Winer EP, Partridge AH. Local Therapy Decision-Making and Contralateral Prophylactic Mastectomy in Young Women with Early-Stage Breast Cancer. Annals Of Surgical Oncology 2015, 22: 3809-3815. PMID: 25930247, PMCID: PMC4598267, DOI: 10.1245/s10434-015-4572-6.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnxietyBody Mass IndexBreast NeoplasmsDecision MakingDirective CounselingFearFemaleGenes, BRCA1Genes, BRCA2Genetic TestingHumansLymphatic MetastasisMastectomy, SegmentalMutationNeoplasm StagingParityPatient ParticipationProphylactic Surgical ProceduresReceptor, ErbB-2RecurrenceTumor BurdenYoung AdultConceptsBreast-conserving surgeryContralateral prophylactic mastectomyEarly-stage breast cancerUnilateral mastectomyBreast cancerYoung womenProphylactic mastectomyUnilateral stage ILarger tumor sizeOngoing cohort studyGood psychosocial supportResultsMedian ageClinical characteristicsCohort studyHER2 positivityNodal involvementLocal therapyLower BMITumor sizeBRCA mutationsPatient-driven decisionSurgical decisionMethodsAs partMultinomial logistic regressionStage I
2013
Breast cancer presentation and diagnostic delays in young women
Ruddy KJ, Gelber S, Tamimi RM, Schapira L, Come SE, Meyer ME, Winer EP, Partridge AH. Breast cancer presentation and diagnostic delays in young women. Cancer 2013, 120: 20-25. PMID: 24347383, DOI: 10.1002/cncr.28287.Peer-Reviewed Original ResearchConceptsCare delaysSymptoms of cancerBreast cancerFirst visitYoung womenMulticenter cohort studyMedical record reviewPatient's first visitBreast cancer presentationBreast abnormalitiesFirst signOwn breast cancerHealth care providersMost young womenPoor financial statusCancer presentationCohort studyDiagnostic delayRecord reviewTumor characteristicsPoor outcomeSystemic symptomsDisease stageEligible participantsExamination abnormalitiesPerceptions, knowledge, and satisfaction with contralateral prophylactic mastectomy among young women with breast cancer: a cross-sectional survey.
Rosenberg SM, Tracy MS, Meyer ME, Sepucha K, Gelber S, Hirshfield-Bartek J, Troyan S, Morrow M, Schapira L, Come SE, Winer EP, Partridge AH. Perceptions, knowledge, and satisfaction with contralateral prophylactic mastectomy among young women with breast cancer: a cross-sectional survey. Annals Of Internal Medicine 2013, 159: 373-81. PMID: 24042365, PMCID: PMC3968260, DOI: 10.7326/0003-4819-159-6-201309170-00003.Peer-Reviewed Original ResearchConceptsContralateral prophylactic mastectomyContralateral breast cancerBreast cancerCross-sectional surveyYoung womenProphylactic mastectomyBilateral breast cancerBreast cancer worryAge 40 yearsCommunity medical centerBRCA2 mutation carriersSusan G. KomenBilateral mastectomyUnaffected breastCancer worryMedical CenterMutation carriersMost womenCancerEvidence-based decisionsMastectomyRecall biasWomenRiskActual riskChoosing mastectomy over lumpectomy: Factors associated with surgical decisions in young women with breast cancer.
Rosenberg S, Sepucha K, Ruddy K, Tamimi R, Gelber S, Meyer M, Schapira L, Come S, Borges V, Winer E, Partridge A. Choosing mastectomy over lumpectomy: Factors associated with surgical decisions in young women with breast cancer. Journal Of Clinical Oncology 2013, 31: 6507-6507. DOI: 10.1200/jco.2013.31.15_suppl.6507.Peer-Reviewed Original ResearchBreast cancerYoung womenSurgical decisionStage IMulti-center cohort studyEstrogen receptor-positive tumorsReceptor-positive tumorsFinal multivariable modelFear of recurrenceDefinitive surgeryNodal involvementCohort studyMedian ageBilateral mastectomyER statusMultivariable analysisLower BMIPositive tumorsTumor sizeSurgical choiceOvarian cancerTumor gradeMultivariable modelMastectomyAge 40Quality of life and psychosocial distress in young women with advanced breast cancer.
Seah D, Gelber S, Ruddy K, Tamimi R, Schapira L, Come S, Meyer M, Larsen B, Winer E, Partridge A. Quality of life and psychosocial distress in young women with advanced breast cancer. Journal Of Clinical Oncology 2013, 31: e20508-e20508. DOI: 10.1200/jco.2013.31.15_suppl.e20508.Peer-Reviewed Original ResearchAdvanced breast cancerQuality of lifePsychosocial distressBreast cancerYoung womenBodily painSF-36 subscale scoresBaseline surveyLongitudinal multi-centre studyMedical chart dataMental health scoresMulti-center studySocial functioningABC diagnosisABC patientsClinical factorsMedian ageMedian timeClinical variablesRole limitationsGeneral healthDepressed womenHealth scoresGeneral populationLogistic regression
2012
Body image in recently diagnosed young women with early breast cancer
Rosenberg SM, Tamimi RM, Gelber S, Ruddy KJ, Kereakoglow S, Borges VF, Come SE, Schapira L, Winer EP, Partridge AH. Body image in recently diagnosed young women with early breast cancer. Psycho-Oncology 2012, 22: 1849-1855. PMID: 23132765, PMCID: PMC3594059, DOI: 10.1002/pon.3221.Peer-Reviewed Original ResearchConceptsCancer Rehabilitation Evaluation SystemMean CARE scoreCare scoresYoung womenBreast cancerMore body image concernsBody image concernsSurgical decision-making processMusculoskeletal pain symptomsProspective cohort studyEarly breast cancerBody imageWomen age 40Impact of treatmentImage concernsRehabilitation Evaluation SystemPotential future interventionsBreast cancer diagnosisMulti-variable analysisLumpectomy groupPain symptomsRadical surgeryCohort studySurgery typePsychological factorsModel Program to Improve Care for a Unique Cancer Population: Young Women With Breast Cancer
Partridge AH, Ruddy KJ, Kennedy J, Winer EP. Model Program to Improve Care for a Unique Cancer Population: Young Women With Breast Cancer. JCO Oncology Practice 2012, 8: e105-e110. PMID: 23277772, PMCID: PMC3439235, DOI: 10.1200/jop.2011.000501.Peer-Reviewed Original ResearchSexual functioning in young women with breast cancer.
Rosenberg S, Tamimi R, Gelber S, Ruddy K, Kereakoglow S, Borges V, Come S, Schapira L, Winer E, Partridge A. Sexual functioning in young women with breast cancer. Journal Of Clinical Oncology 2012, 30: 9100-9100. DOI: 10.1200/jco.2012.30.15_suppl.9100.Peer-Reviewed Original ResearchCancer Rehabilitation Evaluation SystemBreast cancerSexual functioningYoung womenMulti-center cohort studySexual interestRehabilitation Evaluation SystemBody imageAdjuvant therapyPain symptomsCohort studyDysfunction scorePoor body imageMusculoskeletal painSurvivorship periodMenopausal symptomsPoor functionCare scoresSexual dysfunctionActive womenStage 0Age 40Treatment groupsTreatment dataMultivariate analysisThe Effect of Age on Delay in Diagnosis and Stage of Breast Cancer
Partridge AH, Hughes ME, Ottesen RA, Wong Y, Edge SB, Theriault RL, Blayney DW, Niland JC, Winer EP, Weeks JC, Tamimi RM. The Effect of Age on Delay in Diagnosis and Stage of Breast Cancer. The Oncologist 2012, 17: 775-782. PMID: 22554997, PMCID: PMC3380876, DOI: 10.1634/theoncologist.2011-0469.Peer-Reviewed Original ResearchConceptsHigher stage diseaseBreast cancerYoung womenStage diseaseNational Comprehensive Cancer Network centersInitial signsYounger ageHigher stageBreast cancer diagnosisAdvanced diseaseEffect of ageIndependent predictorsSymptomatic diseaseStage ICancerDiagnosisDiseaseSymptomsCancer diagnosisWomenOlder counterpartsAgeSimilar adjustmentSignsDays
2011
P1-08-05: Age and Survival in Women with Early Stage Breast Cancer: An Analysis Controlling for Tumor Subtype.
Partridge A, Hughes M, Ottesen R, Wong Y, Edge S, Theriault R, Blayney D, Niland J, Winer E, Weeks J, Tamimi R. P1-08-05: Age and Survival in Women with Early Stage Breast Cancer: An Analysis Controlling for Tumor Subtype. Cancer Research 2011, 71: p1-08-05-p1-08-05. DOI: 10.1158/0008-5472.sabcs11-p1-08-05.Peer-Reviewed Original ResearchMultivariate Cox proportional hazards modelEarly-stage breast cancerCox proportional hazards modelStage breast cancerProportional hazards modelBreast cancerEstrogen receptorYoung womenProgesterone receptorStratified analysisOlder womenHazards modelTumor subtypesYounger ageBreast cancer-specific survivalHER-2/neu statusCancer-specific survivalER-positive diseaseIndependent risk factorEarly breast cancerER-negative diseaseAge 40 yearsBreast cancer recurrenceEfficacy of therapyBreast cancer biologyP4-11-10: Perceptions, Knowledge and Satisfaction with Contralateral Prophylactic Mastectomy among Young Women with Breast Cancer.
Tracy M, Meyer M, Sepucha K, Gelber S, Hirshfield-Bartek J, Troyan S, Morrow M, Schapira L, Come S, Winer E, Partridge A. P4-11-10: Perceptions, Knowledge and Satisfaction with Contralateral Prophylactic Mastectomy among Young Women with Breast Cancer. Cancer Research 2011, 71: p4-11-10-p4-11-10. DOI: 10.1158/0008-5472.sabcs11-p4-11-10.Peer-Reviewed Original ResearchContralateral prophylactic mastectomyContralateral breast cancerBreast cancerBilateral mastectomyYoung womenProphylactic mastectomyBenefits of CPMEarly breast cancerBilateral breast cancerSurgical treatment decisionsLongitudinal cohort studyBreast cancer treatmentPercent of womenCohort studyContralateral diseaseMedian ageProphylactic indicationsPatient preferencesTreatment decisionsMutation carriersAge 40MastectomyCancerCancer ResCancer treatmentP4-11-12: Molecular Phenotype of Breast Cancers in a Large Cohort of Young Women According to Time Interval Since Pregnancy.
Collins L, Gelber S, Marotti J, Cole K, Kereakoglow S, Ruddy K, Brachtel E, Schapira L, Come S, Borges V, Schedin P, Warner E, Winer E, Partridge A. P4-11-12: Molecular Phenotype of Breast Cancers in a Large Cohort of Young Women According to Time Interval Since Pregnancy. Cancer Research 2011, 71: p4-11-12-p4-11-12. DOI: 10.1158/0008-5472.sabcs11-p4-11-12.Peer-Reviewed Original ResearchNulliparous young womenBreast cancerYoung womenLast pregnancyParous womenNulliparous womenTumor gradeLarge cohortBreast cancer molecular phenotypesPregnancy-associated breast cancerOngoing prospective cohort studyMolecular phenotypesLuminal B cancersCentral pathology reviewProspective cohort studyMonths of diagnosisTriple-negative cancersBreast cancer riskGenomic alterationsHER2 typeParous breastPrior pregnancyB cancersCohort studyMedian agePD04-05: Body Image Issues in Young Breast Cancer Patients: The Impact of Chemotherapy, Hormone Treatment, and Surgery.
Rosenberg S, Tamimi R, Gelber S, Kereakoglow S, Borges V, Come S, Schapira L, Winer E, Partridge A. PD04-05: Body Image Issues in Young Breast Cancer Patients: The Impact of Chemotherapy, Hormone Treatment, and Surgery. Cancer Research 2011, 71: pd04-05-pd04-05. DOI: 10.1158/0008-5472.sabcs11-pd04-05.Peer-Reviewed Original ResearchCare scoresBreast cancerYoung womenConcurrent treatmentTreatment groupsMulti-center prospective cohort studyHormone treatmentYoung breast cancer patientsBody image issuesMean CARE scoreBody imageProspective cohort studyBreast cancer patientsImpact of chemotherapyStage of diseaseTreatment-associated differencesImpact of treatmentHormonal therapyCohort studyHormone therapyRadical surgerySurgical groupMedian ageMedian timeUnadjusted analyses