2024
Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study
Puklin L, Irwin M, Sanft T, Ferrucci L, Harrigan M, McGowan C, Cartmel B, Zupa M, Winer E, Deyling M, Ligibel J, Basen-Engquist K, Spiegelman D, Sharifi M. Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study. Supportive Care In Cancer 2024, 32: 590. PMID: 39141176, DOI: 10.1007/s00520-024-08789-5.Peer-Reviewed Original ResearchConceptsPhysical activityLifestyle interventionSelf-reported PA questionnaireSelf-reported diet qualityBreast cancerHealthy Eating Index-2015Stage I-III breast cancerBenefits of PASequential mixed methods studyI-III breast cancerChemotherapy-related symptomsMixed methods studyThematic content analysisBehavioral goalsSense of controlBody mass indexPA questionnaireSemi-structured interviewsMean body mass indexTranscribed verbatimIntervention armTailored educationDiet qualityNutritional behaviorMental benefits
2021
The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention
Delahanty LM, Wadden TA, Goodwin PJ, Alfano CM, Thomson CA, Irwin ML, Neuhouser ML, Crane TE, Frank E, Spears PA, Gillis BP, Hershman DL, Paskett ED, Hopkins J, Bernstein V, Stearns V, White J, Hudis C, Winer EP, Carey L, Partridge AH, Ligibel JA. The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention. Obesity 2021, 30: 28-38. PMID: 34932888, PMCID: PMC9186690, DOI: 10.1002/oby.23287.Peer-Reviewed Original ResearchConceptsWeight loss interventionWeight loss trialLifestyle interventionHealth education materialsWeight lossLoss trialPhysical activityInvasive disease-free survivalDisease-free survivalBreast cancer patientsBreast cancer diagnosisCare of thousandsEducation materialsBaseline weightCancer outcomesCancer patientsHealth coachesCancer recurrenceBreast cancerCaloric restrictionStage IITrialsCancer diagnosisInterventionWomenPhysical Activity, Weight, and Outcomes in Patients Receiving Chemotherapy for Metastatic Breast Cancer (C40502/Alliance)
Ligibel JA, Huebner L, Rugo HS, Burstein HJ, Toppmeyer DL, Anders CK, Ma C, Barry WT, Suman V, Carey LA, Partridge AH, Hudis CA, Winer EP. Physical Activity, Weight, and Outcomes in Patients Receiving Chemotherapy for Metastatic Breast Cancer (C40502/Alliance). JNCI Cancer Spectrum 2021, 5: pkab025-. PMID: 33981951, PMCID: PMC8103727, DOI: 10.1093/jncics/pkab025.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic Agents, ImmunologicalAntineoplastic Combined Chemotherapy ProtocolsBevacizumabBody HeightBody Mass IndexBody WeightBreast NeoplasmsEpothilonesExerciseFemaleHumansMiddle AgedObesityPaclitaxelProgression-Free SurvivalProportional Hazards ModelsTreatment OutcomeYoung AdultConceptsProgression-free survivalMetastatic breast cancerBody mass indexOverall survivalPhysical activityBreast cancerMass indexMET hoursFirst-line taxane-based chemotherapyHormone receptor-positive cancersBaseline body mass indexFirst-line chemotherapyTaxane-based chemotherapyReceptor-positive cancersRecreational physical activityRates of obesityMetastatic diseaseCox modelingMedian ageOverall mortalityRandomized trialsTask hoursMetabolic equivalentsPatientsCancer
2020
Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial
Brown JC, Zhang S, Ligibel JA, Irwin ML, Jones LW, Campbell N, Pollak MN, Sorrentino A, Cartmel B, Harrigan M, Tolaney SM, Winer EP, Ng K, Abrams TA, Sanft T, Douglas PS, Hu FB, Fuchs CS, Meyerhardt JA. Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial. Cancer Prevention Research 2020, 13: 1055-1062. PMID: 32859615, PMCID: PMC7718298, DOI: 10.1158/1940-6207.capr-20-0188.Peer-Reviewed Original ResearchConceptsHs-CRPColorectal cancerPhysical activityHigh-sensitivity C-reactive proteinLow baseline physical activitySurvivors of breastTrial product estimandBaseline physical activityBiomarkers of inflammationC-reactive proteinMeasures of inflammationImproved clinical outcomesEffects of exerciseType 2 diabetesCombination of exerciseStandard therapyClinical outcomesCancer recurrenceObservational studyTreatment groupsInflammation outcomesMetforminIL6Factorial trialInflammation
2017
Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early breast cancer (Alliance A011401): study design
Ligibel JA, Barry WT, Alfano C, Hershman DL, Irwin M, Neuhouser M, Thomson CA, Delahanty L, Frank E, Spears P, Paskett ED, Hopkins J, Bernstein V, Stearns V, White J, Hahn O, Hudis C, Winer EP, Wadden TA, Goodwin PJ. Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early breast cancer (Alliance A011401): study design. Npj Breast Cancer 2017, 3: 37. PMID: 28948213, PMCID: PMC5608692, DOI: 10.1038/s41523-017-0040-8.Peer-Reviewed Original ResearchEarly breast cancerWeight loss interventionWeight loss programBreast cancer recurrenceBreast cancerBody weightWeight lossLoss interventionLoss programCancer recurrencePhysical activityHER-2 negative breast cancerInvasive disease-free survivalRandomized phase III trialDana-Farber Cancer InstitutePurposeful weight lossBaseline body weightCancer diagnosisDisease-free survivalExcess body weightPhase III trialsPoor prognostic factorIncidence of comorbiditiesBody mass indexWeight loss trial
2009
Impact of a home-based physical activity intervention upon exercise behaviors and anthropometric measures in women undergoing treatment for early stage breast cancer.
Ligibel J, Campbell N, Anita G, Shockro L, Salinardi T, Winer E. Impact of a home-based physical activity intervention upon exercise behaviors and anthropometric measures in women undergoing treatment for early stage breast cancer. Cancer Research 2009, 69: 1117. DOI: 10.1158/0008-5472.sabcs-1117.Peer-Reviewed Original ResearchEarly-stage breast cancerStage breast cancerHome-based exercise interventionBreast cancer patientsQuality of lifeBreast cancerWeight gainAdjuvant chemotherapyExercise interventionCancer patientsPhysical activityBody fatAnthropometric measuresHome-based physical activity interventionSingle-arm pilot studyWeek 12 valuesBreast cancer outcomesPhysical activity interventionsTime of enrollmentArm pilot studyBreast cancer riskImpact of exerciseLean muscle massBreast cancer diagnosisAdjuvant therapyPhysical Activity Behaviors in Women with Newly Diagnosed Ductal Carcinoma-In-Situ
Ligibel JA, Partridge A, Giobbie-Hurder A, Golshan M, Emmons K, Winer EP. Physical Activity Behaviors in Women with Newly Diagnosed Ductal Carcinoma-In-Situ. Annals Of Surgical Oncology 2009, 16: 106-112. PMID: 18953612, PMCID: PMC5842912, DOI: 10.1245/s10434-008-0174-x.Peer-Reviewed Original ResearchConceptsPhysical activityDuctal carcinomaTreatment-related variablesLongitudinal cohort studyStrenuous physical activityBreast cancer riskLogistic regression modelingPhysical activity behaviorType of exerciseTamoxifen useCohort studyBilateral mastectomyEpidemiological evidenceSitu cancerReconstructive surgeryCancer riskDepressive symptomsExercise levelsMost womenExercise frequencyHealth outcomesActivity behaviorWomenExercise behaviorNonsignificant variables
2008
Impact of a Mixed Strength and Endurance Exercise Intervention on Insulin Levels in Breast Cancer Survivors
Ligibel JA, Campbell N, Partridge A, Chen WY, Salinardi T, Chen H, Adloff K, Keshaviah A, Winer EP. Impact of a Mixed Strength and Endurance Exercise Intervention on Insulin Levels in Breast Cancer Survivors. Journal Of Clinical Oncology 2008, 26: 907-912. PMID: 18281663, DOI: 10.1200/jco.2007.12.7357.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsExercise groupCancer survivorsInsulin levelsExercise interventionInsulin concentrationsGlucose levelsBody compositionControl groupOverweight breast cancer survivorsUsual care control groupEndurance exercise interventionCare control groupMicroU/mLSignificant decreaseBreast cancer recurrenceBreast cancer riskBreast cancer prognosisInsulin resistanceHip circumferenceCancer recurrenceBody fatHip measurementsPhysical activityCancer risk
2007
Impact of physical activity on insulin levels in breast cancer survivors
Ligibel J, Campbell N, Chen H, Salinardi T, Chen W, Partridge A, Mantzoros C, Winer E. Impact of physical activity on insulin levels in breast cancer survivors. Journal Of Clinical Oncology 2007, 25: 555-555. DOI: 10.1200/jco.2007.25.18_suppl.555.Peer-Reviewed Original ResearchBreast cancer survivorsInsulin levelsPhysical activityCancer survivorsExercise groupΜIU/Glucose levelsControl groupEarly-stage breast cancerBreast cancer-related deathsBaseline insulin levelsCare control groupStage breast cancerBreast cancer recurrenceBreast cancer riskCancer-related deathBreast cancer prognosisStrength training sessionMeasurements of weightAdjuvant treatmentExercise interventionHip circumferenceInsulin sensitivityCancer recurrenceFat mass
2001
Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy.
Demark-Wahnefried W, Peterson B, Winer E, Marks L, Aziz N, Marcom P, Blackwell K, Rimer B. Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy. Journal Of Clinical Oncology 2001, 19: 2381-9. PMID: 11331316, DOI: 10.1200/jco.2001.19.9.2381.Peer-Reviewed Original ResearchConceptsBreast cancer patientsCancer patientsPhysical activityWeight gainAdjuvant chemotherapySarcopenic obesityCT groupBody compositionPremenopausal breast cancer patientsOperable breast carcinomaReduced physical activityLeg lean massLean body massSignificant differencesLT patientsPremenopausal womenYears postdiagnosisDietary intakeFat massResistance trainingBreast carcinomaMean changeLean massBody fatChemotherapy
1997
Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy.
DemarkWahnefried W, Hars V, Conaway, Havlin K, Rimer B, McElveen G, Winer E. Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy. Rehabilitation Oncology 1997, 15: 21. DOI: 10.1097/01893697-199715030-00018.Peer-Reviewed Original ResearchReduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy
Demark-Wahnefried W, Hars V, Conaway, Havlin K, Rimer B, McElveen G, Winer E. Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy. American Journal Of Clinical Nutrition 1997, 65: 1495-1501. PMID: 9129482, DOI: 10.1093/ajcn/65.5.1495.Peer-Reviewed Original ResearchConceptsBreast cancer patientsAdjuvant chemotherapyCancer patientsPhysical activityEnergy intakeWeight gainBreast cancerBody compositionCompletion of chemotherapyCommon side effectsCourse of therapyDiet-induced thermogenesisQuality of lifePremenopausal patientsLeucovorin chemotherapyChemotherapySide effectsStage IBaseline levelsPatientsImpairs survivalEnergy expenditureOptimal interventionIntakeComplete dataWeight Gain in Women Diagnosed with Breast Cancer
WAHNEFRIED W, RIMER B, WINER E. Weight Gain in Women Diagnosed with Breast Cancer. Journal Of The Academy Of Nutrition And Dietetics 1997, 97: 519-529. PMID: 9145091, DOI: 10.1016/s0002-8223(97)00133-8.Peer-Reviewed Original ResearchConceptsBreast cancerWeight gainRisk of recurrenceQuality of lifeIntensity of treatmentQuantity of lifeMultiagent regimensPremenopausal womenMenopausal statusNodal statusWeight managementDietary intakePhysical activityHigh doseRate of metabolismCancerPatientsEffective interventionsDietetics practitionersLonger durationWomenDecrease survivalFurther studiesPsychosocial researchRecent findings
1993
Why women gain weight with adjuvant chemotherapy for breast cancer.
Demark-Wahnefried W, Winer EP, Rimer BK. Why women gain weight with adjuvant chemotherapy for breast cancer. Journal Of Clinical Oncology 1993, 11: 1418-29. PMID: 8315439, DOI: 10.1200/jco.1993.11.7.1418.Peer-Reviewed Original ResearchConceptsAdjuvant chemotherapyBreast cancer patientsWeight gainCancer patientsBreast cancerEarly-stage breast cancerDietary intervention programCommon side effectsQuality of lifeAmount of weightMultiagent regimensPremenopausal womenDietary intakePhysical activityChemotherapySide effectsEnergy imbalanceEffective interventionsAdverse effectsWomenIntervention programsPatientsAdverse consequencesCancerNumber of investigators