2024
Hypofractionated vs Conventionally Fractionated Postmastectomy Radiation After Implant-Based Reconstruction
Wong J, Uno H, Tramontano A, Fisher L, Pellegrini C, Abel G, Burstein H, Chun Y, King T, Schrag D, Winer E, Bellon J, Cheney M, Hardenbergh P, Ho A, Horst K, Kim J, Leonard K, Moran M, Park C, Recht A, Soto D, Shiloh R, Stinson S, Snyder K, Taghian A, Warren L, Wright J, Punglia R. Hypofractionated vs Conventionally Fractionated Postmastectomy Radiation After Implant-Based Reconstruction. JAMA Oncology 2024, 10: 1370-1378. PMID: 39115975, PMCID: PMC11310844, DOI: 10.1001/jamaoncol.2024.2652.Peer-Reviewed Original ResearchFunctional Assessment of Cancer Therapy-BreastPhysical well-beingPostmastectomy radiation therapyImplant-based reconstructionConventional fractionationStudy armsPhysical well-being scoresUS cancer centersLocal-regional disease controlImprove quality of lifeQuality of lifeAs-treated cohortChest wall doseHigher adverse eventsToxic effectsMain OutcomesRandomized clinical trialsPWB scoreUnpaid timePostmastectomy radiationImplant reconstructionRadiation therapyTreatment breaksImplant-basedImprovement changes
2013
Neoadjuvant bevacizumab: surgical complications of mastectomy with and without reconstruction
Kansal KJ, Dominici LS, Tolaney SM, Isakoff SJ, Smith BL, Jiang W, Brock JE, Winer EP, Krop IE, Golshan M. Neoadjuvant bevacizumab: surgical complications of mastectomy with and without reconstruction. Breast Cancer Research And Treatment 2013, 141: 255-259. PMID: 24026859, DOI: 10.1007/s10549-013-2682-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAngiogenesis InhibitorsAntibodies, Monoclonal, HumanizedAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsBevacizumabBreast NeoplasmsFemaleHumansMammaplastyMastectomyMiddle AgedNeoadjuvant TherapyNeoplasm StagingPostoperative ComplicationsTreatment OutcomeYoung AdultConceptsSurgical complicationsAC/TPostoperative complicationsComplication rateCohort 2Cohort 1Breast cancerExact testImmediate expander/implant reconstructionHER2-negative breast cancerExpander/implant reconstructionOperable breast cancerOverall complication rateRate of complicationsThird of patientsCohort of patientsSame healthcare systemSingle-arm trialFisher's exact testUse of BevTerms of demographicsNeoadjuvant bevacizumabNeoadjuvant therapyImplant reconstructionMastectomyNeoadjuvant bevacizumab: Surgical complications of mastectomy with and without reconstruction.
Kansal K, Dominici L, Tolaney S, Isakoff S, Krop I, Smith B, Jiang W, Potler H, Brock J, Winer E, Golshan M. Neoadjuvant bevacizumab: Surgical complications of mastectomy with and without reconstruction. Journal Of Clinical Oncology 2013, 31: 1100-1100. DOI: 10.1200/jco.2013.31.15_suppl.1100.Peer-Reviewed Original ResearchSurgical complicationsAC/TNeoadjuvant bevacizumabNeoadjuvant therapyComplication rateCohort 2Cohort 1Breast cancerExact testImmediate expander/implant reconstructionHER2-negative breast cancerExpander/implant reconstructionOperable breast cancerUse of bevacizumabOverall complication rateRate of complicationsThird of patientsCohort of patientsSingle-arm trialSame healthcare systemFisher's exact testTerms of demographicsNon-randomized dataPostoperative complicationsImplant reconstruction