P2-17-06: Patterns of Bone Density Evaluation in a Community Population Treated with Aromatase Inhibitors.
Ligibel J, O'Malley A, Fisher M, Daniel G, Winer E, Keating N. P2-17-06: Patterns of Bone Density Evaluation in a Community Population Treated with Aromatase Inhibitors. Cancer Research 2011, 71: p2-17-06-p2-17-06. DOI: 10.1158/0008-5472.sabcs11-p2-17-06.Peer-Reviewed Original ResearchBone density testingBone density evaluationBaseline bone densityAI therapyBone densityDensity testingBone lossAromatase inhibitorsOlder womenHealthCore Integrated Research DatabaseLogistic regressionCommunity-based populationLong-term therapyBreast cancer patientsCommunity-based cohortBone density lossProton pump inhibitorsRisk of fractureLow education levelClinical characteristicsPharmacy dataPump inhibitorsCancer patientsDiagnosis codesAI initiationRisk of myocardial infarction, stroke, and fracture in a cohort of community-based breast cancer patients
Ligibel JA, James O’Malley A, Fisher M, Daniel GW, Winer EP, Keating NL. Risk of myocardial infarction, stroke, and fracture in a cohort of community-based breast cancer patients. Breast Cancer Research And Treatment 2011, 131: 589-597. PMID: 21881937, DOI: 10.1007/s10549-011-1754-1.Peer-Reviewed Original ResearchConceptsAdjuvant aromatase inhibitorsBreast cancer patientsCommunity-based populationCancer patientsSerious side effectsMyocardial infarctionHormonal therapyClinical trialsSide effectsOnly serious side effectTime-varying treatment variablesHealthCore Integrated Research DatabaseCox proportional hazards modelNon-trial populationSide effect profileRisk of osteoporosisProportional hazards modelHip fractureEffect profileDiagnosis codesAromatase inhibitorsHigh riskPropensity score methodsLower riskHazards model