2022
Preclinical and clinical efficacy of trastuzumab deruxtecan in breast cancer brain metastases
Kabraji S, Ni J, Sammons S, Li T, Van Swearingen AED, Wang Y, Pereslete A, Hsu L, DiPiro PJ, Lascola C, Moore H, Hughes M, Raghavendra AS, Gule-Monroe M, Murthy RK, Winer EP, Anders CK, Zhao JJ, Lin NU. Preclinical and clinical efficacy of trastuzumab deruxtecan in breast cancer brain metastases. Clinical Cancer Research 2022, 29: 174-182. PMID: 36074155, PMCID: PMC9811155, DOI: 10.1158/1078-0432.ccr-22-1138.Peer-Reviewed Original ResearchConceptsBreast cancer brain metastasesActive brain metastasesObjective response rateCNS objective response rateCancer brain metastasesBrain metastasesT-DXdPatient-derived xenograftsPDX modelsCohort studyTrastuzumab deruxtecanClinical efficacyClinical trialsHER2-positive breast cancer brain metastasesMetastatic HER2-positive breast cancerResponse rateMulti-institutional cohort studyHER2-positive breast cancerRetrospective multi-institutional cohort studyOrthotopic patient-derived xenograftsRetrospective cohort studyProspective clinical trialsSubset of patientsCentral nervous system activityPivotal clinical trials
2020
Impact of tucatinib on progression free survival in patients with HER2+ metastatic breast cancer and stable or active brain metastases
Bachelot T, Lin N, Murthy R, Hurvitz S, Borges V, Oliveira M, Oakman C, Khan S, Lynch C, Westbrook K, Doyle C, Reinisch M, Colleoni M, Slamon D, Hortobagyi G, Winer E, McGoldrick S, An X, Loibl S. Impact of tucatinib on progression free survival in patients with HER2+ metastatic breast cancer and stable or active brain metastases. Annals Of Oncology 2020, 31: s359-s360. DOI: 10.1016/j.annonc.2020.08.395.Peer-Reviewed Original Research
2012
Randomized trial of a physical activity intervention in patients with metastatic breast cancer.
Ligibel J, Giobbie-Hurder A, Shockro L, Campbell N, Partridge A, Tolaney S, Lin N, Winer E. Randomized trial of a physical activity intervention in patients with metastatic breast cancer. Journal Of Clinical Oncology 2012, 30: 9084-9084. DOI: 10.1200/jco.2012.30.15_suppl.9084.Peer-Reviewed Original ResearchMetastatic breast cancerDiagnosis of MBCPhysical activity interventionsPA interventionsBreast cancerActivity interventionsModerate-intensity PA interventionUsual care control groupEarly-stage breast cancerPhysical Activity Recall interviewFunctional measuresActive brain metastasesEORTC QLQ CCare control groupBruce treadmill testQuality of lifeECOG 0Brain metastasesHormonal therapyQLQ CBiologic therapyMedian ageIntervention armMedian timeTreadmill time