2020
Implications of Abnormal Exercise Electrocardiography With Normal Stress Echocardiography
Daubert MA, Sivak J, Dunning A, Douglas PS, Coyne B, Wang TY, Mark DB, Velazquez EJ. Implications of Abnormal Exercise Electrocardiography With Normal Stress Echocardiography. JAMA Internal Medicine 2020, 180: 494-502. PMID: 31985749, PMCID: PMC6990669, DOI: 10.1001/jamainternmed.2019.6958.Peer-Reviewed Original ResearchMeSH KeywordsCoronary DiseaseEchocardiography, StressElectrocardiographyExercise TestFemaleHumansMaleMiddle AgedPrognosisConceptsNormal stress echocardiographyComposite end pointStress echoExercise electrocardiographyStress echocardiographyMyocardial infarctionDownstream testingEnd pointDuke University Medical CenterExercise stress echoNegative exercise ECGStress ECG findingsAdverse cardiac eventsIncremental prognostic valueObservational cohort studyAdverse clinical eventsCoronary artery diseaseIndividual adverse eventsPopulation of patientsUniversity Medical CenterImaging resultsCoronary revascularizationAdverse eventsCardiac eventsCohort study
2019
Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy
Panza JA, Ellis AM, Al-Khalidi HR, Holly TA, Berman DS, Oh JK, Pohost GM, Sopko G, Chrzanowski L, Mark DB, Kukulski T, Favaloro LE, Maurer G, Farsky PS, Tan RS, Asch FM, Velazquez EJ, Rouleau JL, Lee KL, Bonow RO. Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy. New England Journal Of Medicine 2019, 381: 739-748. PMID: 31433921, PMCID: PMC6814246, DOI: 10.1056/nejmoa1807365.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassEchocardiography, StressFemaleFollow-Up StudiesHeartHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedMyocardial IschemiaProportional Hazards ModelsProspective StudiesStroke VolumeTomography, Emission-Computed, Single-PhotonTreatment OutcomeVentricular Function, LeftConceptsLeft ventricular ejection fractionVentricular ejection fractionMedical therapyEjection fractionMyocardial viabilityIschemic cardiomyopathyLeft ventricular systolic functionGoals of revascularizationCoronary artery bypassPrimary end pointVentricular systolic functionCoronary artery diseaseLeft ventricular functionLong-term outcomesLong-term survivalSurgical revascularizationDobutamine echocardiographyMedian durationSystolic functionArtery diseaseVentricular functionViable myocardiumLong-term benefitsLower incidenceCABG
2018
Crowdsourcing consensus: proposal of a novel method for assessing accuracy in echocardiography interpretation
Minter S, Armour A, Tinnemore A, Strub K, Crowley AL, Bloomfield GS, Alexander JH, Douglas PS, Kisslo JA, Velazquez EJ, Samad Z. Crowdsourcing consensus: proposal of a novel method for assessing accuracy in echocardiography interpretation. The International Journal Of Cardiovascular Imaging 2018, 34: 1725-1730. PMID: 30128849, DOI: 10.1007/s10554-018-1389-y.Peer-Reviewed Original ResearchConceptsStress echocardiography studyObstructive coronary diseaseGold standardWall motion abnormalitiesCoronary angiography dataCoronary diseaseStress echocardiographyEchocardiography studyHard outcomesMotion abnormalitiesStress echoSurvey participants' responsesClinical readsEchocardiographic interpretationImperfect gold standardIndependent consensusParticipants' responsesEchocardiographic imagesAngiography dataEchocardiography interpretationValidation surveyParticipantsEchocardiographyConsensusFirst survey
2017
Safety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose
Lu MT, Douglas PS, Udelson JE, Adami E, Ghoshhajra BB, Picard MH, Roberts R, Lee KL, Einstein AJ, Mark DB, Velazquez EJ, Carter W, Ridner M, Al-Khalidi HR, Hoffmann U. Safety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose. Journal Of Cardiovascular Computed Tomography 2017, 11: 373-382. PMID: 28838846, PMCID: PMC6201309, DOI: 10.1016/j.jcct.2017.08.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina PectorisComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEchocardiography, StressFemaleHumansIncidental FindingsMaleMiddle AgedMultidetector Computed TomographyNorth AmericaPredictive Value of TestsProspective StudiesRadiation DosageRadiation ExposureRadionuclide ImagingRisk AssessmentRisk FactorsConceptsStable chest painMore incidental findingsIncidental findingLow radiation doseChest painPatient characteristicsRadiation doseNuclear stress testingCoronary CT angiographyRadiation dose variesCumulative radiation doseAdvanced CT scannersMinor complicationsPROMISE trialRandomized comparisonTomography angiographyFunctional testingTest choiceFunctional testing strategyCT angiographyNuclear stressPulmonary nodulesSimilar outcomesComplicationsDose
2015
Severity of Remodeling, Myocardial Viability, and Survival in Ischemic LV Dysfunction After Surgical Revascularization
Bonow RO, Castelvecchio S, Panza JA, Berman DS, Velazquez EJ, Michler RE, She L, Holly TA, Desvigne-Nickens P, Kosevic D, Rajda M, Chrzanowski L, Deja M, Lee KL, White H, Oh JK, Doenst T, Hill JA, Rouleau JL, Menicanti L, Investigators S. Severity of Remodeling, Myocardial Viability, and Survival in Ischemic LV Dysfunction After Surgical Revascularization. JACC Cardiovascular Imaging 2015, 8: 1121-1129. PMID: 26363840, PMCID: PMC4633018, DOI: 10.1016/j.jcmg.2015.03.013.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassCoronary Artery DiseaseEchocardiography, StressFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardiumPredictive Value of TestsProportional Hazards ModelsProspective StudiesRecovery of FunctionRisk FactorsStroke VolumeTime FactorsTissue SurvivalTomography, Emission-Computed, Single-PhotonTreatment OutcomeUnited StatesVentricular Dysfunction, LeftVentricular Function, LeftVentricular RemodelingConceptsEnd-systolic volume indexEnd-systolic volumeEffect of CABGIschemic LV dysfunctionMedical therapyMyocardial viabilityLV dysfunctionViable myocardiumLV end-systolic volume indexMedian end-systolic volume indexSmaller end-systolic volumeCoronary artery bypassLV systolic dysfunctionMarker of severityCoronary artery diseaseLeft ventricular remodelingPre-specified criteriaSingle photon emissionSTICH trialSurgical revascularizationArtery bypassDobutamine echocardiographySystolic dysfunctionArtery diseaseIschemic cardiomyopathyOutcomes of Anatomical versus Functional Testing for Coronary Artery Disease
Douglas PS, Hoffmann U, Patel MR, Mark DB, Al-Khalidi HR, Cavanaugh B, Cole J, Dolor RJ, Fordyce CB, Huang M, Khan MA, Kosinski AS, Krucoff MW, Malhotra V, Picard MH, Udelson JE, Velazquez EJ, Yow E, Cooper LS, Lee KL. Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease. New England Journal Of Medicine 2015, 372: 1291-1300. PMID: 25773919, PMCID: PMC4473773, DOI: 10.1056/nejmoa1415516.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary artery diseaseCTA groupSymptomatic patientsArtery diseaseComposite primary end pointPrimary end-point eventEnd pointRadiation exposureInvasive cardiac catheterizationMajor procedural complicationsPrimary end pointSecondary end pointsEnd-point eventsCumulative radiation exposureMedian followChest painUnstable anginaCardiac catheterizationMore patientsProcedural complicationsClinical outcomesRandomized trialsAnatomical testingMean age
2014
PROspective Multicenter Imaging Study for Evaluation of chest pain: Rationale and design of the PROMISE trial
Douglas PS, Hoffmann U, Lee KL, Mark DB, Al-Khalidi HR, Anstrom K, Dolor RJ, Kosinski A, Krucoff MW, Mudrick DW, Patel MR, Picard MH, Udelson JE, Velazquez EJ, Cooper L, investigators P. PROspective Multicenter Imaging Study for Evaluation of chest pain: Rationale and design of the PROMISE trial. American Heart Journal 2014, 167: 796-803.e1. PMID: 24890527, PMCID: PMC4044617, DOI: 10.1016/j.ahj.2014.03.003.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePROMISE trialAnatomical testingProspective Multicenter Imaging StudyDiagnostic strategiesInitial diagnostic strategyMajor procedural complicationsSubsequent care decisionsComposite of deathPrimary end pointLarge pragmatic trialClinical care teamQuality of lifeDiagnostic testing strategiesMultidetector coronaryChest painSymptomatic patientsUnstable anginaArtery diseaseProcedural complicationsRandomized trialsSymptomatic subjectsClinical effectivenessMyocardial infarctionPragmatic trialImpaired Resting Myocardial Annular Velocities Are Independently Associated With Mental Stress–Induced Ischemia in Coronary Heart Disease
Ersbøll M, Al Enezi F, Samad Z, Sedberry B, Boyle SH, O’Connor C, Jiang W, Velazquez EJ, Investigators R. Impaired Resting Myocardial Annular Velocities Are Independently Associated With Mental Stress–Induced Ischemia in Coronary Heart Disease. JACC Cardiovascular Imaging 2014, 7: 351-361. PMID: 24631512, PMCID: PMC3992174, DOI: 10.1016/j.jcmg.2013.10.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedChi-Square DistributionEchocardiography, DopplerEchocardiography, StressExercise TestFemaleHumansLogistic ModelsMaleMiddle AgedMyocardial ContractionMyocardial IschemiaOdds RatioPredictive Value of TestsRandomized Controlled Trials as TopicRisk FactorsStress, PsychologicalStroke VolumeVentricular Function, LeftConceptsMental stress-induced ischemiaStress-induced myocardial ischemiaLeft ventricular ejection fractionTissue Doppler myocardial velocitiesVentricular ejection fractionMental stress testMyocardial velocitiesMyocardial ischemiaEjection fractionHeart diseaseConventional exercise stress testingWall motion index scoreIschemic ST-segment changesMyocardial tissue Doppler velocitiesRegional wall motion abnormalitiesPreclinical cardiac dysfunctionStress-induced ischemiaCoronary artery diseaseExercise stress testingTissue Doppler velocitiesCoronary heart diseaseLate diastolic velocityST-segment changesWall motion abnormalitiesStress–Induced IschemiaUtility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy
Khouri MG, Hornsby WE, Risum N, Velazquez EJ, Thomas S, Lane A, Scott JM, Koelwyn GJ, Herndon JE, Mackey JR, Douglas PS, Jones LW. Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy. Breast Cancer Research And Treatment 2014, 143: 531-539. PMID: 24390149, PMCID: PMC4521213, DOI: 10.1007/s10549-013-2818-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreast NeoplasmsDoxorubicinEchocardiography, StressExercise TestFemaleHeart DiseasesHumansMiddle AgedConceptsGlobal longitudinal strainBreast cancer patientsSubclinical cardiac dysfunctionCardiac dysfunctionCancer patientsCardiac indexStress echocardiographyEarly breast cancer patientsLongitudinal strainVentricular ejection fraction assessmentLeft ventricular ejection fraction assessmentAdult oncology settingsPost-exercise increaseEarly breast cancerLeft ventricular functionSex-matched controlsSpeckle tracking echocardiographyEjection fraction assessmentSimilar LVEFAdjuvant therapyEchocardiographic parametersCardiopulmonary exerciseAsymptomatic womenVentricular functionCardiopulmonary function
2013
Inducible Myocardial Ischemia and Outcomes in Patients With Coronary Artery Disease and Left Ventricular Dysfunction
Panza JA, Holly TA, Asch FM, She L, Pellikka PA, Velazquez EJ, Lee KL, Borges-Neto S, Farsky PS, Jones RH, Berman DS, Bonow RO. Inducible Myocardial Ischemia and Outcomes in Patients With Coronary Artery Disease and Left Ventricular Dysfunction. Journal Of The American College Of Cardiology 2013, 61: 1860-1870. PMID: 23500234, PMCID: PMC3755503, DOI: 10.1016/j.jacc.2013.02.014.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseDobutamine stress echocardiogramLV ejection fractionInducible myocardial ischemiaEjection fractionMedical therapyMyocardial ischemiaCause mortalityVentricular dysfunctionArtery diseaseClinical endpointsMultivessel coronary artery diseaseOptimal medical therapyRadionuclide stress testsCoronary artery bypassSevere LV dysfunctionLeft ventricular dysfunctionStress-induced ischemiaPrevious myocardial infarctionSummed difference scoreStress testingRNS testingSTICH patientsSTICH trialArtery bypass
2011
Myocardial Viability and Survival in Ischemic Left Ventricular Dysfunction
Bonow RO, Maurer G, Lee KL, Holly TA, Binkley PF, Desvigne-Nickens P, Drozdz J, Farsky PS, Feldman AM, Doenst T, Michler RE, Berman DS, Nicolau JC, Pellikka PA, Wrobel K, Alotti N, Asch FM, Favaloro LE, She L, Velazquez EJ, Jones RH, Panza JA. Myocardial Viability and Survival in Ischemic Left Ventricular Dysfunction. New England Journal Of Medicine 2011, 364: 1617-1625. PMID: 21463153, PMCID: PMC3290901, DOI: 10.1056/nejmoa1100358.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiovascular DiseasesCombined Modality TherapyCoronary Artery BypassCoronary Artery DiseaseEchocardiography, StressFemaleFollow-Up StudiesHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial IschemiaMyocardiumProportional Hazards ModelsStatistics, NonparametricTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsCoronary artery diseaseVentricular dysfunctionMedical therapyMyocardial viabilityArtery diseaseViable myocardiumSurvival benefitBaseline variablesIschemic left ventricular dysfunctionDifferential survival benefitSubstudy of patientsCoronary artery bypassLeft ventricular dysfunctionDobutamine echocardiographyUnderwent assessmentPatientsCABGDysfunctionTreatment assignmentTherapyMyocardiumDiseaseGreater likelihoodMortalityTrials