2018
The relationship between baseline and follow-up left ventricular ejection fraction with adverse events among primary prevention ICD patients
Friedman DJ, Fudim M, Overton R, Shaw LK, Patel D, Pokorney SD, Velazquez EJ, Al-Khatib SM. The relationship between baseline and follow-up left ventricular ejection fraction with adverse events among primary prevention ICD patients. American Heart Journal 2018, 201: 17-24. PMID: 29910051, PMCID: PMC6309220, DOI: 10.1016/j.ahj.2018.03.017.Peer-Reviewed Original ResearchConceptsLeft ventricular assist devicePrimary prevention ICD patientsAppropriate ICD therapyVentricular ejection fractionImplantable cardioverter defibrillatorICD therapyICD implantationEjection fractionICD patientsMultivariable Cox proportional hazards modelsPrimary prevention implantable cardioverter defibrillatorsCo-primary study endpointsPrimary prevention ICD recipientsFollow-up left ventricular ejection fractionLeft ventricular ejection fractionCox proportional hazards modelComposite of timeLong-term followProportional hazards modelVentricular assist deviceLong-term riskBaseline LVEFLVEF improvementAdverse eventsComposite endpoint
2017
Sudden cardiac death after acute heart failure hospital admission: insights from ASCEND‐HF
Pokorney SD, Al‐Khatib S, Sun J, Schulte P, O'Connor CM, Teerlink JR, Armstrong PW, Ezekowitz JA, Starling RC, Voors AA, Velazquez EJ, Hernandez AF, Mentz RJ. Sudden cardiac death after acute heart failure hospital admission: insights from ASCEND‐HF. European Journal Of Heart Failure 2017, 20: 525-532. PMID: 29266564, DOI: 10.1002/ejhf.1078.Peer-Reviewed Original ResearchConceptsSudden cardiac deathVT/VFHeart failure hospital admissionsAcute HFCardiac deathHospital admissionVentricular tachycardia/ventricular fibrillationDecompensated Heart Failure (ASCEND-HF) trialChronic obstructive pulmonary diseaseVT/VF eventsEvent ratesComposite event rateMeier event ratesHeart Failure TrialCause mortality ratesDay of admissionObstructive pulmonary diseaseLonger QRS durationCause mortalityBaseline characteristicsComposite endpointEjection fractionPulmonary diseaseASCEND-HFFailure TrialSudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting
Rao MP, Al-Khatib SM, Pokorney SD, She L, Romanov A, Nicolau JC, Lee KL, Carson P, Selzman CH, Stepinska J, Cleland JG, Tungsubutra W, Desvigne-Nickens PM, Sueta CA, Siepe M, Lang I, Feldman AM, Yii M, Rouleau JL, Velazquez EJ. Sudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting. Circulation 2017, 135: 1136-1144. PMID: 28154006, PMCID: PMC5516272, DOI: 10.1161/circulationaha.116.026075.Peer-Reviewed Original ResearchMeSH KeywordsAgedAtrial FibrillationCoronary Artery BypassDeath, Sudden, CardiacFemaleFollow-Up StudiesHeart FailureHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedMultivariate AnalysisNatriuretic Peptide, BrainPostoperative PeriodProportional Hazards ModelsReceptors, Tumor Necrosis FactorRisk FactorsStroke VolumeVentricular Function, LeftConceptsCoronary artery bypass graft surgerySudden cardiac deathEnd-systolic volume indexB-type natriuretic peptideVentricular ejection fractionSurgical ventricular reconstructionCardiac deathEjection fractionHeart failureNatriuretic peptideVentricular reconstructionPreoperative end-systolic volume indexLow left ventricular ejection fractionIncidence of SCDPredictors of SCDArtery bypass graft surgeryCoronary Artery Bypass GraftingLeft ventricular ejection fractionVolume indexArtery Bypass GraftingBypass graft surgeryIschemic heart failureContemporary clinical trialsBlinded committeeSTICH trial
2014
Impact of Cardiovascular Events on Change in Quality of Life and Utilities in Patients After Myocardial Infarction A VALIANT Study (Valsartan In Acute Myocardial Infarction)
Lewis EF, Li Y, Pfeffer MA, Solomon SD, Weinfurt KP, Velazquez EJ, Califf RM, Rouleau JL, Kober L, White HD, Schulman KA, Reed SD. Impact of Cardiovascular Events on Change in Quality of Life and Utilities in Patients After Myocardial Infarction A VALIANT Study (Valsartan In Acute Myocardial Infarction). JACC Heart Failure 2014, 2: 159-165. PMID: 24720924, DOI: 10.1016/j.jchf.2013.12.003.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedAngiotensin II Type 1 Receptor BlockersAngiotensin-Converting Enzyme InhibitorsBundle-Branch BlockCaptoprilDeath, Sudden, CardiacDrug Therapy, CombinationFemaleHealth StatusHeart FailureHospitalizationHumansMaleMyocardial InfarctionQuality of LifeRecurrenceStrokeSurvivorsTetrazolesTreatment OutcomeValineValsartanConceptsNonfatal CV eventsEQ-5D assessmentCV eventsVisual analog scaleEQ-5D scoresCardiovascular eventsMyocardial infarctionEQ-5DBaseline EQ-5D scoresKillip class IINonfatal cardiovascular eventsHealth-related qualityLinear mixed-effects regression modelsQuality of lifeMixed effects regression modelsVALIANT studyWorse HRQLVAS scoresEjection fractionNonfatal eventsMI survivorsAnalog scaleVALIANT trialGeneric instrumentsPatients
2013
Early Echocardiographic Deformation Analysis for the Prediction of Sudden Cardiac Death and Life-Threatening Arrhythmias After Myocardial Infarction
Ersbøll M, Valeur N, Andersen MJ, Mogensen UM, Vinther M, Svendsen JH, Møller JE, Kisslo J, Velazquez EJ, Hassager C, Søgaard P, Køber L. Early Echocardiographic Deformation Analysis for the Prediction of Sudden Cardiac Death and Life-Threatening Arrhythmias After Myocardial Infarction. JACC Cardiovascular Imaging 2013, 6: 851-860. PMID: 23850252, DOI: 10.1016/j.jcmg.2013.05.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedArrhythmias, CardiacDeath, Sudden, CardiacDefibrillators, ImplantableDenmarkEchocardiographyElectric CountershockFemaleHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPredictive Value of TestsPrimary PreventionProportional Hazards ModelsProspective StudiesRisk FactorsStroke VolumeTreatment OutcomeVentricular Function, LeftConceptsGlobal longitudinal strainAcute myocardial infarctionSudden cardiac deathMalignant ventricular arrhythmiasMyocardial infarctionNet reclassification indexVentricular arrhythmiasCardiac deathAddition of GLSMeasurement of GLSSCD/VAsChronic ischemic heart failureNovel echocardiographic parametersPrimary composite endpointPrimary composite outcomeIschemic heart failureEchocardiographic parametersPrimary endpointComposite outcomeHospital dischargeLate complicationsMultivariate adjustmentComposite endpointHeart failureRisk stratification
2011
Circumstances and Outcomes of Sudden Unexpected Death in Patients With High-Risk Myocardial Infarction
Ye S, Grunnert M, Thune JJ, Stephenson KM, Uno H, Finn PV, McMurray JJ, Velazquez EJ, Califf R, Pfeffer MA, Solomon SD. Circumstances and Outcomes of Sudden Unexpected Death in Patients With High-Risk Myocardial Infarction. Circulation 2011, 123: 2674-2680. PMID: 21606398, DOI: 10.1161/circulationaha.110.990655.Peer-Reviewed Original ResearchConceptsHigh-risk myocardial infarctionSudden deathMyocardial infarctionHospital eventsVentricular tachycardia/ventricular fibrillationPrevention of SDSD eventsLong-term mortalityMajority of patientsSudden unexpected deathInitial ECG rhythmCatastrophic complicationUnwitnessed arrestsUnexpected deathVentricular fibrillationTrial trialsPatientsInfarctionECG rhythmDeathPreventionHigher proportionHome eventsArrestSource documentation
2010
Pathogenesis of Sudden Unexpected Death in a Clinical Trial of Patients With Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both
Pouleur AC, Barkoudah E, Uno H, Skali H, Finn PV, Zelenkofske SL, Belenkov YN, Mareev V, Velazquez EJ, Rouleau JL, Maggioni AP, Køber L, Califf RM, McMurray JJ, Pfeffer MA, Solomon SD. Pathogenesis of Sudden Unexpected Death in a Clinical Trial of Patients With Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both. Circulation 2010, 122: 597-602. PMID: 20660803, DOI: 10.1161/circulationaha.110.940619.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overDeath, Sudden, CardiacFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedMyocardial InfarctionTime FactorsVentricular Dysfunction, LeftConceptsSudden unexpected deathRecurrent MISudden deathArrhythmic deathAutopsy recordsUnexpected deathAcute Myocardial Infarction trialImplantable cardioverter-defibrillator therapyEarly post-myocardial infarction periodPost-myocardial infarction periodMyocardial Infarction trialCardioverter-defibrillator therapySudden death eventsIndex MILack of benefitSeries of casesCardiovascular causesNoncardiovascular causesVentricular dysfunctionAcute MICardiac ruptureHeart failureAutopsy evidenceClinical groundsAutopsy findingsDoes Myocardial Perfusion Imaging Provide Incremental Prognostic Information to Left Ventricular Ejection Fraction?
Mudrick DW, Velazquez E, Borges-Neto S. Does Myocardial Perfusion Imaging Provide Incremental Prognostic Information to Left Ventricular Ejection Fraction? Current Cardiology Reports 2010, 12: 155-161. PMID: 20425171, DOI: 10.1007/s11886-010-0093-x.Peer-Reviewed Original ResearchMeSH KeywordsCardiac-Gated Single-Photon Emission Computer-Assisted TomographyCoronary Artery DiseaseDeath, Sudden, CardiacHumansMass ScreeningMyocardial Perfusion ImagingPositron-Emission TomographyPredictive Value of TestsPrognosisRisk AssessmentSensitivity and SpecificityStroke VolumeVentricular Function, LeftConceptsEjection fractionVentricular functionNonfatal cardiac eventsGated single-photon emissionIncremental prognostic informationSignificant coronary diseaseVentricular ejection fractionCoronary artery diseaseOptimal treatment strategySudden cardiac deathNuclear imaging studiesImportant clinical implicationsMyocardial perfusion imagingPositron emission tomographySingle photon emissionIschemic burdenCardiac eventsArtery diseaseCardiac deathCoronary diseasePrognostic informationTreatment strategiesMyocardial perfusionPerfusion imagingBest predictor
2009
Usefulness of the Duke Sudden Cardiac Death Risk Score for Predicting Sudden Cardiac Death in Patients With Angiographic (>75% Narrowing) Coronary Artery Disease
Atwater BD, Thompson VP, Vest RN, Shaw LK, Mazzei WR, Al-Khatib SM, Hranitzky PM, Bahnson TD, Velazquez EJ, Califf RM, Lee KL, Roe MT. Usefulness of the Duke Sudden Cardiac Death Risk Score for Predicting Sudden Cardiac Death in Patients With Angiographic (>75% Narrowing) Coronary Artery Disease. The American Journal Of Cardiology 2009, 104: 1624-1630. PMID: 19962465, DOI: 10.1016/j.amjcard.2009.07.042.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary AngiographyCoronary Artery DiseaseDeath, Sudden, CardiacFemaleHumansMaleMiddle AgedPredictive Value of TestsRisk AssessmentRisk FactorsConceptsCoronary artery diseaseSCD risk scoreRisk of SCDArtery diseaseRisk scoreSCD riskDepressed left ventricular ejection fractionAngiographic coronary artery diseasePredicting Sudden Cardiac DeathLeft ventricular ejection fractionNative coronary artery stenosisCox proportional hazards modelVentricular ejection fractionSudden cardiac deathCoronary artery stenosisDeath risk scorePatient characteristic variablesRisk prediction toolsDiseased coronary arteriesProportional hazards modelAngiographic characteristicsRisk patientsCardiac deathCoronary angiographyDiabetes mellitusPredictors of sudden cardiac death change with time after myocardial infarction: results from the VALIANT trial
Piccini JP, Zhang M, Pieper K, Solomon SD, Al-Khatib SM, Van de Werf F, Pfeffer MA, McMurray JJ, Califf RM, Velazquez EJ. Predictors of sudden cardiac death change with time after myocardial infarction: results from the VALIANT trial. European Heart Journal 2009, 31: 211-221. PMID: 19854729, DOI: 10.1093/eurheartj/ehp425.Peer-Reviewed Original ResearchConceptsSudden cardiac deathMyocardial infarctionInitial left ventricular ejection fractionRisk of SCDLeft ventricular ejection fractionHigher baseline heart rateBaseline creatinine clearanceBaseline clinical characteristicsRecurrent cardiovascular eventsPrior myocardial infarctionVentricular ejection fractionBaseline heart rateCox proportional hazardsCardiovascular eventsClinical characteristicsCreatinine clearanceCumulative incidenceCardiac deathEjection fractionEntire followRisk stratificationVALIANT trialPost-MIRisk stratifierLandmark analysis
2008
Relation of Mortality to Failure to Prescribe Beta Blockers Acutely in Patients With Sustained Ventricular Tachycardia and Ventricular Fibrillation Following Acute Myocardial Infarction (from the VALsartan In Acute myocardial iNfarcTion trial [VALIANT] Registry)
Piccini JP, Hranitzky PM, Kilaru R, Rouleau JL, White HD, Aylward PE, Van de Werf F, Solomon SD, Califf RM, Velazquez EJ. Relation of Mortality to Failure to Prescribe Beta Blockers Acutely in Patients With Sustained Ventricular Tachycardia and Ventricular Fibrillation Following Acute Myocardial Infarction (from the VALsartan In Acute myocardial iNfarcTion trial [VALIANT] Registry). The American Journal Of Cardiology 2008, 102: 1427-1432. PMID: 19026290, DOI: 10.1016/j.amjcard.2008.07.033.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedClinical Trials as TopicDeath, Sudden, CardiacDrug PrescriptionsFemaleHospital MortalityHumansIncidenceLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPractice Patterns, Physicians'RegistriesRetrospective StudiesRisk AssessmentRisk FactorsTachycardia, VentricularTime FactorsVentricular FibrillationConceptsSustained VT/ventricular fibrillationVT/ventricular fibrillationBeta-blocker therapyAcute myocardial infarctionHeart failureVentricular fibrillationBeta blockersVentricular tachycardiaMyocardial infarctionAcute beta-blocker therapyOral beta blockadeBeta-blocker useHospital mortality rateSustained ventricular arrhythmiasMultivariable logistic regressionSustained ventricular tachycardiaRelation of mortalityBeta blockadeHospital mortalityHospital deathKillip classificationBaseline characteristicsVentricular arrhythmiasEarly mortalityWorse outcomes
2007
Racial Disparity in the Utilization of Implantable-Cardioverter Defibrillators Among Patients With Prior Myocardial Infarction and an Ejection Fraction of ≤35%
Thomas KL, Al-Khatib SM, Kelsey RC, Bush H, Brosius L, Velazquez EJ, Peterson ED, Gilliam FR. Racial Disparity in the Utilization of Implantable-Cardioverter Defibrillators Among Patients With Prior Myocardial Infarction and an Ejection Fraction of ≤35%. The American Journal Of Cardiology 2007, 100: 924-929. PMID: 17826371, DOI: 10.1016/j.amjcard.2007.04.024.Peer-Reviewed Original ResearchConceptsSudden cardiac deathLeft ventricular systolic dysfunctionVentricular systolic dysfunctionCardiac deathEjection fractionBlack patientsMyocardial infarctionSystolic dysfunctionWhite patientsPrimary preventionSignificant left ventricular systolic dysfunctionLower mean ejection fractionSudden cardiac death rateCardiac death rateMean ejection fractionPrior myocardial infarctionMultivariate logistic regressionImplantable cardioverter defibrillatorClinical characteristicsICD implantationICD useOverall mortalityProphylactic implantationPatient raceNational registry
2006
Navigating the Crossroads of Coronary Artery Disease and Heart Failure
Gheorghiade M, Sopko G, De Luca L, Velazquez EJ, Parker JD, Binkley PF, Sadowski Z, Golba KS, Prior DL, Rouleau JL, Bonow RO. Navigating the Crossroads of Coronary Artery Disease and Heart Failure. Circulation 2006, 114: 1202-1213. PMID: 16966596, DOI: 10.1161/circulationaha.106.623199.Peer-Reviewed Original Research
2005
Sudden Death in Patients with Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both
Solomon SD, Zelenkofske S, McMurray JJ, Finn PV, Velazquez E, Ertl G, Harsanyi A, Rouleau JL, Maggioni A, Kober L, White H, Van de Werf F, Pieper K, Califf RM, Pfeffer MA. Sudden Death in Patients with Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both. New England Journal Of Medicine 2005, 352: 2581-2588. PMID: 15972864, DOI: 10.1056/nejmoa043938.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionVentricular ejection fractionLeft ventricular dysfunctionMyocardial infarctionCardiac arrestSudden deathVentricular dysfunctionEjection fractionHeart failureLeft ventricular systolic functionHigh-risk patientsVentricular systolic functionSudden unexpected deathAcute myocardial infarctionCardiac causesHospital dischargeSystolic functionPercent confidence intervalsUnexpected deathHigh riskInfarctionPatientsResuscitationDysfunctionDeath
2004
Prognostic usefulness of left ventricular thrombus by echocardiography in dilated cardiomyopathy in predicting stroke, transient ischemic attack, and death
Crawford TC, Smith WT, Velazquez EJ, Taylor SM, Jollis JG, Kisslo J. Prognostic usefulness of left ventricular thrombus by echocardiography in dilated cardiomyopathy in predicting stroke, transient ischemic attack, and death. The American Journal Of Cardiology 2004, 93: 500-503. PMID: 14969636, DOI: 10.1016/j.amjcard.2003.10.056.Peer-Reviewed Original Research