2018
Crowdsourcing consensus: proposal of a novel method for assessing accuracy in echocardiography interpretation
Minter S, Armour A, Tinnemore A, Strub K, Crowley AL, Bloomfield GS, Alexander JH, Douglas PS, Kisslo JA, Velazquez EJ, Samad Z. Crowdsourcing consensus: proposal of a novel method for assessing accuracy in echocardiography interpretation. The International Journal Of Cardiovascular Imaging 2018, 34: 1725-1730. PMID: 30128849, DOI: 10.1007/s10554-018-1389-y.Peer-Reviewed Original ResearchConceptsStress echocardiography studyObstructive coronary diseaseGold standardWall motion abnormalitiesCoronary angiography dataCoronary diseaseStress echocardiographyEchocardiography studyHard outcomesMotion abnormalitiesStress echoSurvey participants' responsesClinical readsEchocardiographic interpretationImperfect gold standardIndependent consensusParticipants' responsesEchocardiographic imagesAngiography dataEchocardiography interpretationValidation surveyParticipantsEchocardiographyConsensusFirst surveyThe Impact of a Rigorous Quality Program on 3D Echocardiography Data Quality in an International Multisite Randomized Trial
Crowley AL, Yow E, Rabineau D, Norris C, White J, Daubert MA, Velazquez EJ, Barnhart H, Krucoff MW, Rao SV, Douglas PS. The Impact of a Rigorous Quality Program on 3D Echocardiography Data Quality in an International Multisite Randomized Trial. JACC Cardiovascular Imaging 2018, 11: 1918-1920. PMID: 30121272, DOI: 10.1016/j.jcmg.2018.05.024.Peer-Reviewed Original ResearchRight Ventricular Longitudinal Strain Reproducibility Using Vendor-Dependent and Vendor-Independent Software
Il'Giovine ZJ, Mulder H, Chiswell K, Arges K, Tomfohr J, Hashmi A, Velazquez EJ, Kisslo JA, Samad Z, Rajagopal S. Right Ventricular Longitudinal Strain Reproducibility Using Vendor-Dependent and Vendor-Independent Software. Journal Of The American Society Of Echocardiography 2018, 31: 721-732.e5. PMID: 29525250, PMCID: PMC6825401, DOI: 10.1016/j.echo.2018.01.008.Peer-Reviewed Original ResearchConceptsVendor-independent softwarePeak systolic longitudinal strainRight ventricular functionSingle-center studySystolic longitudinal strainMulticenter clinical trialCongenital heart diseaseRepeated-measures analysisRVLS valuesPulmonary hypertensionVentricular functionVendor-specific softwareHeart diseaseClinical trialsEchocardiographic scansClinical practiceLongitudinal strainWidespread variabilityDiseaseGlobal strainDifferent ultrasound scannersEffect of scannerWide variabilityRegional strainPossible interactions
2017
Improving on the diagnostic characteristics of echocardiography for pulmonary hypertension
Broderick-Forsgren K, Davenport CA, Sivak JA, Hargett CW, Foster MC, Monteagudo A, Armour A, Rajagopal S, Arges K, Velazquez EJ, Samad Z. Improving on the diagnostic characteristics of echocardiography for pulmonary hypertension. The International Journal Of Cardiovascular Imaging 2017, 33: 1341-1349. PMID: 28337558, DOI: 10.1007/s10554-017-1114-2.Peer-Reviewed Original ResearchMeSH KeywordsArea Under CurveCardiac CatheterizationEchocardiographyHumansHypertension, PulmonaryHypertrophy, Right VentricularModels, CardiovascularPredictive Value of TestsPulmonary ArteryReproducibility of ResultsRetrospective StudiesROC CurveVentricular Dysfunction, RightVentricular Function, RightVentricular PressureConceptsValue of echoRight heart catheterizationPulmonary hypertensionComplex congenital heart diseaseRight heart parametersEcho parametersCongenital heart diseaseVentricular assist deviceDiagnostic characteristicsTime of studyLower RVSPPA enlargementRV dysfunctionRV enlargementEchocardiographic parametersHeart catheterizationHeart transplantationAdult patientsProspective cohortMechanical ventilationRetrospective studyHeart diseaseAssist deviceRVSPScreening test
2016
Implementing a Continuous Quality Improvement Program in a High-Volume Clinical Echocardiography Laboratory
Samad Z, Minter S, Armour A, Tinnemore A, Sivak JA, Sedberry B, Strub K, Horan SM, Harrison JK, Kisslo J, Douglas PS, Velazquez EJ. Implementing a Continuous Quality Improvement Program in a High-Volume Clinical Echocardiography Laboratory. Circulation Cardiovascular Imaging 2016, 9: e003708. PMID: 26957220, DOI: 10.1161/circimaging.115.003708.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisCardiac CatheterizationCritical PathwaysEchocardiography, DopplerFeasibility StudiesHemodynamicsHospitals, High-VolumeHumansObserver VariationPatient Care TeamPractice Patterns, Physicians'Predictive Value of TestsProgram EvaluationProspective StudiesQuality ImprovementQuality Indicators, Health CareReproducibility of ResultsSeverity of Illness IndexWorkflowConceptsAortic stenosisCatheterization dataContinuous quality improvementMean gradientAortic valve mean gradientCQI teamClinical echocardiography laboratoryGreater aortic stenosisProportion of patientsReferral of patientsPrimary outcome measureContinuous quality improvement programQuality Improvement ProgramAortic gradientCardiac catheterizationEchocardiographic diagnosisEchocardiography studyPractice patternsInvasive studiesOutcome measuresEchocardiography laboratoryValve hemodynamicsSecond sonographerCatheterizationCQI programAn Approach to Improve the Negative Predictive Value and Clinical Utility of Transthoracic Echocardiography in Suspected Native Valve Infective Endocarditis
Sivak JA, Vora AN, Navar AM, Schulte PJ, Crowley AL, Kisslo J, Corey GR, Liao L, Wang A, Velazquez EJ, Samad Z. An Approach to Improve the Negative Predictive Value and Clinical Utility of Transthoracic Echocardiography in Suspected Native Valve Infective Endocarditis. Journal Of The American Society Of Echocardiography 2016, 29: 315-322. PMID: 26850679, PMCID: PMC6052444, DOI: 10.1016/j.echo.2015.12.009.Peer-Reviewed Original ResearchConceptsInitial transthoracic echocardiographyNative valve infective endocarditisTransthoracic echocardiographyTransesophageal echocardiographyNegative predictive valueInfective endocarditisPredictive valueNegative resultsNegative findingsNative valve endocarditisValve endocarditisClinical suspicionIntermediate riskSingle institutionTransthoracic approachCurrent guidelinesTransthoracic studyDiagnostic characteristicsRetrospective analysisClinical utilityPatientsEndocarditisEchocardiographyDiagnostic performanceGold standard
2015
Influence of QRS infarct score and QRS duration prior to transcatheter aortic valve replacement on follow-up left ventricular end systolic volume in patients with new persistent left bundle branch block
Hannink LG, Wagner GS, Kisslo J, Alenezi FA, Shaw LK, Hofmann P, Zusterzeel R, Phelan M, Velazquez EJ, Gorgels AP. Influence of QRS infarct score and QRS duration prior to transcatheter aortic valve replacement on follow-up left ventricular end systolic volume in patients with new persistent left bundle branch block. Journal Of Electrocardiology 2015, 48: 637-642. PMID: 25959263, DOI: 10.1016/j.jelectrocard.2015.04.010.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAortic Valve StenosisBundle-Branch BlockDiagnosis, Computer-AssistedEchocardiographyElectrocardiographyFemaleFollow-Up StudiesHumansMalePrognosisReproducibility of ResultsRetrospective StudiesRisk AssessmentSensitivity and SpecificityStroke VolumeTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsLeft bundle branch blockTranscatheter aortic valve replacementPersistent left bundle branch blockVentricular end-systolic volumeAortic valve replacementBundle branch blockEnd-systolic volumeQRS durationInfarct scoreValve replacementVentricular functionBranch blockNew-onset left bundle branch blockLeft ventricular end-systolic volumeNew left bundle branch blockLeft ventricular functionLarger study populationStrict inclusion criteriaSuch predictive valueQRS scoreSystolic volumeInclusion criteriaStudy populationCardiac conditionsPredictive value
2012
Variability of Global Left Ventricular Deformation Analysis Using Vendor Dependent and Independent Two-Dimensional Speckle-Tracking Software in Adults
Risum N, Ali S, Olsen NT, Jons C, Khouri MG, Lauridsen TK, Samad Z, Velazquez EJ, Sogaard P, Kisslo J. Variability of Global Left Ventricular Deformation Analysis Using Vendor Dependent and Independent Two-Dimensional Speckle-Tracking Software in Adults. Journal Of The American Society Of Echocardiography 2012, 25: 1195-1203. PMID: 22981228, DOI: 10.1016/j.echo.2012.08.007.Peer-Reviewed Original ResearchMechanisms and Predictors of Mitral Regurgitation after High-Risk Myocardial Infarction
Meris A, Amigoni M, Verma A, Thune JJ, Køber L, Velazquez E, McMurray JJ, Pfeffer MA, Califf R, Levine RA, Solomon SD, Investigators V. Mechanisms and Predictors of Mitral Regurgitation after High-Risk Myocardial Infarction. Journal Of The American Society Of Echocardiography 2012, 25: 535-542. PMID: 22305962, PMCID: PMC3501447, DOI: 10.1016/j.echo.2012.01.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAngiotensin-Converting Enzyme InhibitorsCaptoprilDisease ProgressionEchocardiography, Doppler, ColorElectrocardiographyFemaleFollow-Up StudiesHumansMaleMiddle AgedMitral Valve InsufficiencyMonitoring, PhysiologicMultivariate AnalysisMyocardial InfarctionPredictive Value of TestsProspective StudiesReference ValuesReproducibility of ResultsRisk AssessmentROC CurveSeverity of Illness IndexSex FactorsStatistics, NonparametricStroke VolumeTetrazolesTime FactorsValineValsartanVentricular Dysfunction, LeftVentricular RemodelingConceptsHigh-risk myocardial infarctionBaseline mitral regurgitationMitral regurgitationMyocardial infarctionAtrial sizeIndependent predictorsCoaptation depthProgression of MRMitral valve deformationStructural valve diseaseSevere mitral regurgitationFunctional mitral regurgitationIschemic mitral regurgitationGood-quality echocardiogramsMitral annular areaMitral tentingMR degreeLV dysfunctionTenting areaBaseline characteristicsDiastolic functionHeart failureValve diseaseLV remodelingVentricular remodeling
2010
Prevalence and predictors of mechanical dyssynchrony as defined by phase analysis in patients with left ventricular dysfunction undergoing gated SPECT myocardial perfusion imaging
Samad Z, Atchley AE, Trimble MA, Sun JL, Shaw LK, Pagnanelli R, Chen J, Garcia EV, Iskandrian AE, Velazquez EJ, Borges-Neto S. Prevalence and predictors of mechanical dyssynchrony as defined by phase analysis in patients with left ventricular dysfunction undergoing gated SPECT myocardial perfusion imaging. Journal Of Nuclear Cardiology 2010, 18: 24-30. PMID: 21082299, PMCID: PMC3077282, DOI: 10.1007/s12350-010-9310-7.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlgorithmsCardiac-Gated Single-Photon Emission Computer-Assisted TomographyFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedIncidenceMaleMyocardial Perfusion ImagingNorth CarolinaPrevalenceReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificityVentricular Dysfunction, LeftConceptsLeft ventricular dysfunctionMechanical dyssynchronyVentricular dysfunctionIndependent predictorsBlack raceQRS durationPhase SDGated SPECT myocardial perfusionLeft ventricular ejection fractionTomography myocardial perfusion imagingStress scoresVentricular ejection fractionIschemic heart diseasePopulation of patientsMeasures of dyssynchronySPECT myocardial perfusionMyocardial perfusion imagingSingle photon emissionSignificant dyssynchronyEjection fractionEntire cohortUnivariate predictorsClinical variablesHeart diseaseMale gender
2009
Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction
Atchley AE, Trimble MA, Samad Z, Shaw LK, Pagnanelli R, Chen J, Garcia EV, Iskandrian AE, Velazquez EJ, Borges-Neto S. Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction. Journal Of Nuclear Cardiology 2009, 16: 888-894. PMID: 19690935, PMCID: PMC3048054, DOI: 10.1007/s12350-009-9136-3.Peer-Reviewed Original ResearchConceptsModerate LV dysfunctionSevere LV dysfunctionLV dysfunctionMechanical dyssynchronyQRS durationNormal controlsGated SPECTModerate left ventricular dysfunctionNYHA class IIIPrevalence of dyssynchronyLeft ventricular dysfunctionCohort of patientsMajority of patientsLV mechanical dyssynchronyGated SPECT imagingCurrent selection criteriaLess dyssynchronyLVEF 35More dyssynchronyVentricular dysfunctionPatient selectionDyssynchronyPatientsSPECT perfusionDysfunction
2008
Repeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony
Trimble MA, Velazquez EJ, Adams GL, Honeycutt EF, Pagnanelli RA, Barnhart HX, Chen J, Iskandrian AE, Garcia EV, Borges-Neto S. Repeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony. Nuclear Medicine Communications 2008, 29: 374-381. PMID: 18317303, PMCID: PMC3048057, DOI: 10.1097/mnm.0b013e3282f81380.Peer-Reviewed Original ResearchConceptsSingle photon emissionLeft ventricular dysfunctionTomography perfusion imagingPhase standard deviationNormal controlsPerfusion imagingVentricular dysfunctionTomography myocardial perfusion imagingMyocardial perfusion imagingIntraclass correlation coefficientCardiac dyssynchronyDyssynchronyPatientsInterobserver comparisonsIntraobserver comparisonsDysfunctionPhase indexMean absolute differenceImaging
2006
Comparison of Regional Versus Global Assessment of Left Ventricular Function in Patients with Left Ventricular Dysfunction, Heart Failure, or Both After Myocardial Infarction: The Valsartan in Acute Myocardial Infarction Echocardiographic Study
Thune JJ, Køber L, Pfeffer MA, Skali H, Anavekar NS, Bourgoun M, Ghali JK, Arnold JM, Velazquez EJ, Solomon SD. Comparison of Regional Versus Global Assessment of Left Ventricular Function in Patients with Left Ventricular Dysfunction, Heart Failure, or Both After Myocardial Infarction: The Valsartan in Acute Myocardial Infarction Echocardiographic Study. Journal Of The American Society Of Echocardiography 2006, 19: 1462-1465. PMID: 17138030, DOI: 10.1016/j.echo.2006.05.028.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsComorbidityEchocardiographyFemaleHeart FailureHumansInternationalityMaleMiddle AgedMyocardial InfarctionPrevalencePrognosisReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificityStroke VolumeTetrazolesValineValsartanVentricular Dysfunction, LeftConceptsWall motion indexMyocardial infarctionHeart failureLV dysfunctionEjection fractionIndependent predictorsGlobal assessmentLeft ventricular dysfunctionLV systolic functionVentricular ejection fractionAdditional prognostic informationLeft ventricular functionAcute myocardial infarctionBiplane Simpson's ruleWall motion assessmentVentricular dysfunctionSystolic functionEchocardiographic studyVentricular functionMultivariable analysisPrognostic valueAdverse outcomesPrognostic informationLVEFRegional dysfunction