2014
Sex Differences in Platelet Reactivity and Cardiovascular and Psychological Response to Mental Stress in Patients With Stable Ischemic Heart Disease Insights From the REMIT Study
Samad Z, Boyle S, Ersboll M, Vora AN, Zhang Y, Becker RC, Williams R, Kuhn C, Ortel TL, Rogers JG, O’Connor C, Velazquez EJ, Jiang W, Investigators R. Sex Differences in Platelet Reactivity and Cardiovascular and Psychological Response to Mental Stress in Patients With Stable Ischemic Heart Disease Insights From the REMIT Study. Journal Of The American College Of Cardiology 2014, 64: 1669-1678. PMID: 25323254, PMCID: PMC4752118, DOI: 10.1016/j.jacc.2014.04.087.Peer-Reviewed Original ResearchConceptsMental stress-induced myocardial ischemiaIschemic heart diseaseStable ischemic heart diseaseLeft ventricular ejection fractionPlatelet aggregation responseMental stress taskMental stressTransthoracic echocardiographyPlatelet reactivityStress-induced myocardial ischemiaIschemic ST-segment changesRegional wall motion abnormalitiesAggregation responseStress taskMost baseline characteristicsVentricular ejection fractionHigher baseline depressionLong-term outcomesST-segment changesWall motion abnormalitiesPlatelet aggregation studiesSex differencesBaseline characteristicsBlood pressureEjection fractionImpaired Resting Myocardial Annular Velocities Are Independently Associated With Mental Stress–Induced Ischemia in Coronary Heart Disease
Ersbøll M, Al Enezi F, Samad Z, Sedberry B, Boyle SH, O’Connor C, Jiang W, Velazquez EJ, Investigators R. Impaired Resting Myocardial Annular Velocities Are Independently Associated With Mental Stress–Induced Ischemia in Coronary Heart Disease. JACC Cardiovascular Imaging 2014, 7: 351-361. PMID: 24631512, PMCID: PMC3992174, DOI: 10.1016/j.jcmg.2013.10.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedChi-Square DistributionEchocardiography, DopplerEchocardiography, StressExercise TestFemaleHumansLogistic ModelsMaleMiddle AgedMyocardial ContractionMyocardial IschemiaOdds RatioPredictive Value of TestsRandomized Controlled Trials as TopicRisk FactorsStress, PsychologicalStroke VolumeVentricular Function, LeftConceptsMental stress-induced ischemiaStress-induced myocardial ischemiaLeft ventricular ejection fractionTissue Doppler myocardial velocitiesVentricular ejection fractionMental stress testMyocardial velocitiesMyocardial ischemiaEjection fractionHeart diseaseConventional exercise stress testingWall motion index scoreIschemic ST-segment changesMyocardial tissue Doppler velocitiesRegional wall motion abnormalitiesPreclinical cardiac dysfunctionStress-induced ischemiaCoronary artery diseaseExercise stress testingTissue Doppler velocitiesCoronary heart diseaseLate diastolic velocityST-segment changesWall motion abnormalitiesStress–Induced Ischemia
2013
Effect of Escitalopram on Mental Stress–Induced Myocardial Ischemia: Results of the REMIT Trial
Jiang W, Velazquez EJ, Kuchibhatla M, Samad Z, Boyle SH, Kuhn C, Becker RC, Ortel TL, Williams RB, Rogers JG, O’Connor C. Effect of Escitalopram on Mental Stress–Induced Myocardial Ischemia: Results of the REMIT Trial. JAMA 2013, 309: 2139-2149. PMID: 23695483, PMCID: PMC4378823, DOI: 10.1001/jama.2013.5566.Peer-Reviewed Original ResearchConceptsMental stress-induced myocardial ischemiaStable coronary heart diseaseExercise-induced ischemiaCoronary heart diseaseMyocardial ischemiaHeart diseaseVentricular ejection fraction reductionStress-induced myocardial ischemiaMental stressRegional wall motion abnormalitiesEjection fraction reductionPlacebo-controlled trialST-segment depressionEffect of escitalopramTertiary medical centerWall motion abnormalitiesWeeks of escitalopramSignificant differencesEnd-point assessmentStressor taskEscitalopram groupCardiac eventsEscitalopram treatmentMore patientsTreat analysisPrevalence and Clinical Characteristics of Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Heart Disease
Jiang W, Samad Z, Boyle S, Becker RC, Williams R, Kuhn C, Ortel TL, Rogers J, Kuchibhatla M, O'Connor C, Velazquez EJ. Prevalence and Clinical Characteristics of Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Heart Disease. Journal Of The American College Of Cardiology 2013, 61: 714-722. PMID: 23410543, PMCID: PMC3913125, DOI: 10.1016/j.jacc.2012.11.037.Peer-Reviewed Original ResearchConceptsMental stress-induced ischemiaStress-induced ischemiaCoronary heart diseaseMental stress-induced myocardial ischemiaStable coronary heart diseaseStress-induced myocardial ischemiaExercise-induced ischemiaHeart diseaseMyocardial ischemiaClinical characteristicsHigh riskMental Stress–Induced Myocardial IschemiaExercise-induced myocardial ischemiaVentricular ejection fraction reductionRegional wall motion abnormalitiesEjection fraction reductionST-segment depressionMental stress testWall motion abnormalitiesUnmarried menEligible patientsPoor prognosisMotion abnormalitiesRisk factorsExercise test
2012
Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy
Oh JK, Velazquez EJ, Menicanti L, Pohost GM, Bonow RO, Lin G, Hellkamp AS, Ferrazzi P, Wos S, Rao V, Berman D, Bochenek A, Cherniavsky A, Rogowski J, Rouleau JL, Lee KL, Investigators O. Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy. European Heart Journal 2012, 34: 39-47. PMID: 22584648, PMCID: PMC3533917, DOI: 10.1093/eurheartj/ehs021.Peer-Reviewed Original ResearchConceptsEnd-systolic volume indexSurgical ventricular reconstructionRegional wall motion abnormalitiesWall motion abnormalitiesEjection fractionBetter LVEFIschemic cardiomyopathyVentricular reconstructionMotion abnormalitiesLV end-systolic volume indexMedian end-systolic volume indexBaseline left ventricular functionIschemic Heart Failure (STICH) trialEnd-diastolic volume indexVolume indexBaseline LV functionCoronary artery bypassHeart Failure TrialLeft ventricular functionClinical trial registrationLeft ventricular function parametersLV global functionVentricular function parametersCardiovascular magnetic resonanceML/m2