2007
Polymorphisms in Adenosine Receptor Genes are Associated with Infarct Size in Patients with Ischemic Cardiomyopathy
Tang Z, Diamond MA, Chen J, Holly TA, Bonow RO, Dasgupta A, Hyslop T, Purzycki A, Wagner J, McNamara DM, Kukulski T, Wos S, Velazquez EJ, Ardlie K, Feldman AM. Polymorphisms in Adenosine Receptor Genes are Associated with Infarct Size in Patients with Ischemic Cardiomyopathy. Clinical Pharmacology & Therapeutics 2007, 82: 435-440. PMID: 17728764, DOI: 10.1038/sj.clpt.6100331.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsBase SequenceCardiomyopathiesCase-Control StudiesDNA Mutational AnalysisGene FrequencyGenetic Predisposition to DiseaseHeart VentriclesHumansMolecular Sequence DataMutationMyocardial InfarctionMyocardial IschemiaPhenotypePolymorphism, Single NucleotideReceptor, Adenosine A1Receptor, Adenosine A2AReceptor, Adenosine A3Risk FactorsSeverity of Illness IndexVentricular Function, LeftConceptsIschemic cardiomyopathyInfarct sizeAdenosine receptor geneReceptor geneGenetic variantsPopulation of patientsVentricular functionVentricular sizeIschemic preconditioningNormal controlsHeart responseAdenosine receptorsCardiomyopathyIschemiaPatientsIndividual responsesDNA samplesResponsePolymorphismTherapyInjuryGenesVariants
2005
Therapies to prevent heart failure post-myocardial infarction
Thomas KL, Velazquez EJ. Therapies to prevent heart failure post-myocardial infarction. Current Heart Failure Reports 2005, 2: 174-182. PMID: 16332310, DOI: 10.1007/bf02696647.Peer-Reviewed Original ResearchConceptsPost-MI heart failureHeart failureMyocardial infarctionPresence of HFHeart failure post-myocardial infarctionEvidence-based medicationsMortality of patientsOutcomes of patientsVentricular systolic dysfunctionLower blood pressureTreatment of patientsAcute myocardial infarctionPost-myocardial infarctionKillip classSystolic dysfunctionCommon complicationBlood pressureClinical factorsRevascularization proceduresInfarct sizePoor prognosisPatient populationMale genderPost-MIRisk factors
2002
Revascularization improves survival in ischemic cardiomyopathy regardless of electrocardiographic criteria for prior small-to-medium myocardial infarcts
Shah BR, Velazquez E, Shaw LK, Bart B, O'Connor C, Wagner GS. Revascularization improves survival in ischemic cardiomyopathy regardless of electrocardiographic criteria for prior small-to-medium myocardial infarcts. American Heart Journal 2002, 143: 111-117. PMID: 11773920, DOI: 10.1067/mhj.2002.119996.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionIschemic cardiomyopathyMyocardial infarctionQRS scoreTreatment groupsSelvester QRS scoring systemVentricular ejection fractionMajor coronary arteriesPrevious myocardial infarctionAcute myocardial infarctionQRS scoring systemSignificant treatment differencesElectrocardiographic evidenceCoronary angiographyEjection fractionIndependent predictorsInfarct sizeCoronary arteryHibernating myocardiumRevascularizationDecreased functionBetter survivalMyocardial infarctElectrocardiographic criteriaPatients