Diastolic Dysfunction in Patients With Human Immunodeficiency Virus Receiving Antiretroviral Therapy: Results From the CHART Study
Butler J, Greene SJ, Shah SH, Shah SJ, Anstrom KJ, Kim RJ, Kalogeropoulos AP, Velazquez EJ, Hernandez AF, Desvigne-Nickens P, Scherzer R, Hsue PY, Braunwald E. Diastolic Dysfunction in Patients With Human Immunodeficiency Virus Receiving Antiretroviral Therapy: Results From the CHART Study. Journal Of Cardiac Failure 2019, 26: 371-380. PMID: 31682908, PMCID: PMC7195219, DOI: 10.1016/j.cardfail.2019.10.011.Peer-Reviewed Original ResearchConceptsDiastolic dysfunctionBody mass indexAntiretroviral therapyN-terminal pro-B-type natriuretic peptide levelsPro-B-type natriuretic peptide levelsHuman immunodeficiency virus-infected individualsCross-sectional case-control studyLow-density lipoprotein levelsHigher body mass indexHigh-sensitivity troponin IHIV RNA copiesSignificant valvular diseaseNatriuretic peptide levelsHigher interleukin-6Normal ejection fractionVirus-infected individualsLeft atrial sizePersistent atrial fibrillationProgressive cardiac remodelingSymptom frequency scoreAntiretroviral Therapy studyCardiac magnetic resonanceCase-control studyCarboxyl-terminal telopeptideCD4 count