2024
L-type calcium channel regulation of depression, anxiety and anhedonia-related behavioral phenotypes following chronic stress exposure
Nunes E, Kebede N, Rajadhyaksha A, Addy N. L-type calcium channel regulation of depression, anxiety and anhedonia-related behavioral phenotypes following chronic stress exposure. Neuropharmacology 2024, 257: 110031. PMID: 38871116, PMCID: PMC11334593, DOI: 10.1016/j.neuropharm.2024.110031.Peer-Reviewed Original ResearchChronic unpredictable stressHome cage controlsElevated plus mazeForced swim testSucrose preference testCUS-induced decreaseChronic stress exposureImmobility timeStress exposureL-type calcium channelsDays of chronic unpredictable stressAnxiogenic-like behavioral responsesForced swim test immobility timeBehavioral responsesPre-existing mental health challengesAntidepressant-like responseOpen arm timeMood-related disordersRegulation of depressionExposure to chronic stressorsMale ratsL-type calcium channel blocker isradipineArm timePlus mazeSucrose preference
2023
Ventral tegmental area M5 muscarinic receptors mediate effort-choice responding and nucleus accumbens dopamine in a sex-specific manner
Nunes E, Kebede N, Haight J, Foster D, Lindsley C, Conn P, Addy N. Ventral tegmental area M5 muscarinic receptors mediate effort-choice responding and nucleus accumbens dopamine in a sex-specific manner. Journal Of Pharmacology And Experimental Therapeutics 2023, 385: jpet-ar-2022-001438. PMID: 36828630, PMCID: PMC10108441, DOI: 10.1124/jpet.122.001438.Peer-Reviewed Original ResearchConceptsNucleus accumbens coreVentral tegmental areaM5 receptorsDA releaseMale ratsVTA infusionsDepressive disorderNucleus accumbensMuscarinic M5 receptorsSelective negative allosteric modulatorM5 muscarinic receptorsNegative allosteric modulatorsEffort-related choicePhasic DA releasePotential sex differencesSex-specific mannerACh toneVTA administrationCholinergic effectsMuscarinic receptorsFemale ratsTegmental areaPreclinical modelsDopamine releaseTherapeutic target