Effort-Related Motivational Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Animal Models of the Motivational Symptoms of Depression
Nunes E, Randall P, Hart E, Freeland C, Yohn S, Baqi Y, Müller C, López-Cruz L, Correa M, Salamone J. Effort-Related Motivational Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Animal Models of the Motivational Symptoms of Depression. Journal Of Neuroscience 2013, 33: 19120-19130. PMID: 24305809, PMCID: PMC3850037, DOI: 10.1523/jneurosci.2730-13.2013.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine A2 Receptor AntagonistsAdrenergic Uptake InhibitorsAnimalsAntidepressive Agents, Second-GenerationBehavior, AnimalBupropionConditioning, OperantDepressionDisease Models, AnimalDopamineDopamine and cAMP-Regulated Phosphoprotein 32EnkephalinsFeeding BehaviorImmunohistochemistryMaleMicrodialysisMotivationNucleus AccumbensProto-Oncogene Proteins c-fosRatsRats, Sprague-DawleySubstance PTetrabenazineVesicular Monoamine Transport ProteinsXanthinesConceptsMotivational symptomsAnimal modelsEffort-related choice behaviorAdenosine A2A antagonist MSX-3Vesicular monoamine transport (VMAT-2) inhibitor tetrabenazineEffort-related motivational effectsEffort-related motivational symptomsAccumbens medium spiny neuronsVMAT-2 inhibitor tetrabenazineD2 DA receptorsDepression-like effectsDose-related decreaseMedium spiny neuronsEffects of tetrabenazineInhibitor tetrabenazineEffort-related choiceEffort-related effectsDA receptorsAntidepressant bupropionChow intakeMSX-3Spiny neuronsMajor depressionExtracellular dopamineFood intake