Paired Box 9 (PAX9), the RNA polymerase II transcription factor, regulates human ribosome biogenesis and craniofacial development
Farley-Barnes KI, Deniz E, Overton MM, Khokha MK, Baserga SJ. Paired Box 9 (PAX9), the RNA polymerase II transcription factor, regulates human ribosome biogenesis and craniofacial development. PLOS Genetics 2020, 16: e1008967. PMID: 32813698, PMCID: PMC7437866, DOI: 10.1371/journal.pgen.1008967.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell NucleolusDevelopmental DisabilitiesEmbryonic DevelopmentGene Expression Regulation, DevelopmentalHumansNeural CrestPAX9 Transcription FactorProtein BiosynthesisRibosomesRNA Polymerase IIXenopusConceptsRNA polymerase II transcription factorsCraniofacial developmentTranscription factorsRibosome biogenesis factorsHuman ribosome biogenesisNeural crest developmentBox 9Tissue-specific mannerRibosome biogenesisRibosome productionHuman ribosomopathiesExpression of proteinsPax9 functionBiogenesis factorsXenopus tropicalisCrest developmentSmall subunitEmbryonic developmentCellular machinesUnexpected layerLevels of proteinRibosomopathiesHuman cellsProtein synthesisRibosomes