2012
Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex
Schindler EA, Harvey JA, Aloyo VJ. Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex. Brain Research 2012, 1491: 98-108. PMID: 23123701, PMCID: PMC3559188, DOI: 10.1016/j.brainres.2012.10.057.Peer-Reviewed Original ResearchMeSH KeywordsAmphetaminesAnimalsBehavior, AnimalCerebral CortexEnzyme ActivationEnzyme InhibitorsEstrenesHallucinogensHead MovementsHydrolysisLysergic Acid DiethylamideMaleMicroinjectionsPhosphatidylinositolsPrefrontal CortexPyrrolidinonesRabbitsReceptor, Serotonin, 5-HT2ASerotonin AntagonistsSerotonin Receptor AgonistsSignal TransductionType C PhospholipasesConceptsMedial prefrontal cortexLysergic acid diethylamidePI hydrolysisReceptor antagonistPrefrontal cortexDimethoxy-4Acid diethylamidePhospholipase CDistinct pharmacological propertiesEffects of hallucinogensActivation of PLCTissue prismsSerotonergic receptorsReceptor mechanismsPhosphatidylinositol hydrolysisPharmacological propertiesIntracellular mechanismsPLC inhibitorPLC activationHead bobsTrien-17Receptor signalsHallucinogensNovel findingsAntagonist
2010
Intrahippocampal LSD accelerates learning and desensitizes the 5-HT2A receptor in the rabbit, Romano et al.
Romano AG, Quinn JL, Li L, Dave KD, Schindler EA, Aloyo VJ, Harvey JA. Intrahippocampal LSD accelerates learning and desensitizes the 5-HT2A receptor in the rabbit, Romano et al. Psychopharmacology 2010, 212: 441-448. PMID: 20827462, DOI: 10.1007/s00213-010-2004-7.Peer-Reviewed Original ResearchConceptsDorsal hippocampusDevelopment of desensitizationD-lysergic acid diethylamideEyeblink conditioningChronic administrationAminopropane hydrochlorideLast infusionIntrahippocampal injectionReceptor agonistParenteral injectionSerotonin 5HippocampusTrace eyeblink conditioningAcid diethylamideReceptorsPavlovian conditioningConditioning sessionsVehicle controlInjectionAgonists