Serotonergic and dopaminergic distinctions in the behavioral pharmacology of (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD)
Schindler EA, Dave KD, Smolock EM, Aloyo VJ, Harvey JA. Serotonergic and dopaminergic distinctions in the behavioral pharmacology of (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Pharmacology Biochemistry And Behavior 2011, 101: 69-76. PMID: 22197710, PMCID: PMC3272148, DOI: 10.1016/j.pbb.2011.12.002.Peer-Reviewed Original ResearchConceptsHead-bobbing behaviourLysergic acid diethylamideReceptor antagonistEx vivoDimethoxy-4Acute drug injectionAcid diethylamideChronic drug treatmentBehavioral pharmacologyMechanism of actionReceptor binding propertiesDrug injectionDrug treatmentAnimal modelsReceptor activationBehavioral effectsClinical literatureReceptorsAntagonist ligandsNaïve rabbitsPharmacologyHallucinogensAntagonistAminopropaneVivo