2020
Effect of Concurrent Dementia on Heart Failure Hospital Outcomes: Nationwide Inpatient Sample (2007–2014)
Vuong J, Akintoye E, Kim S, Desai A, Dorbala S. Effect of Concurrent Dementia on Heart Failure Hospital Outcomes: Nationwide Inpatient Sample (2007–2014). Journal Of Cardiac Failure 2020, 27: 258-260. PMID: 32505818, DOI: 10.1016/j.cardfail.2020.05.020.Peer-Reviewed Original ResearchAortic Valve Replacement for Severe Aortic Stenosis Before and During the Era of Transcatheter Aortic Valve Implantation
Akintoye E, Ando T, Sandio A, Adegbala O, Salih M, Zubairu J, Oseni A, Sistla P, Alqasrawi M, Egbe A, Mentias A, Afonso L, Briasoulis A, Panaich S, Desai M. Aortic Valve Replacement for Severe Aortic Stenosis Before and During the Era of Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2020, 126: 73-81. PMID: 32336533, DOI: 10.1016/j.amjcard.2020.03.038.Peer-Reviewed Original ResearchConceptsSevere aortic stenosisAortic valve replacementNational Inpatient SampleTAVI eraAortic stenosisMean annual changeValve replacementFavorable short-term outcomesTranscatheter aortic valve replacementTranscatheter aortic valve implantationRate of AVRAcute kidney injuryRate of strokeAortic valve implantationShort-term outcomesRisk-adjusted ratesHospital mortalityPre-TAVIHospital outcomesKidney injuryHome dischargeHospital dischargePacemaker implantationValve implantationMedian length
2019
Clinical Impact of Atrial Fibrillation on Short-Term Outcomes and In-Hospital Mortality in Patients with Takotsubo Syndrome: A Propensity-Matched National Study
Yassin A, Subahi A, Adegbala O, Abubakar H, Dawdy J, Mishra T, Akintoye E, Shereef H, Ghandour M, Alhusain R, Shokr M, Oviedo C, Afonso L. Clinical Impact of Atrial Fibrillation on Short-Term Outcomes and In-Hospital Mortality in Patients with Takotsubo Syndrome: A Propensity-Matched National Study. Cardiovascular Revascularization Medicine 2019, 21: 522-526. PMID: 31439442, DOI: 10.1016/j.carrev.2019.07.022.Peer-Reviewed Original ResearchConceptsCost of hospitalizationAtrial fibrillationHospital mortalityHospital complicationsVentricular arrhythmiasNational Inpatient Sample databasePropensity score-matched analysisMajor cardiac complicationsTakotsubo syndrome patientsIn-Hospital MortalityNon-routine dischargeAtrial fibrillation groupAtrial fibrillation patientsShort-term outcomesNational Inpatient SampleLength of stayPotential confounding factorsCardiac complicationsHospital stayFibrillation groupFibrillation patientsSecondary outcomesTakotsubo syndromePrimary outcomeCardiac arrestTrends in In-Hospital Mortality, Length of Stay, Nonroutine Discharge, and Cost Among End-Stage Renal Disease Patients on Dialysis Hospitalized With Heart Failure (2001–2014)
Inampudi C, Akintoye E, Bengaluru Jayanna M, Asleh R, Briasouli A, Alvarez P, Briasoulis A. Trends in In-Hospital Mortality, Length of Stay, Nonroutine Discharge, and Cost Among End-Stage Renal Disease Patients on Dialysis Hospitalized With Heart Failure (2001–2014). Journal Of Cardiac Failure 2019, 25: 524-533. PMID: 30844441, DOI: 10.1016/j.cardfail.2019.02.020.Peer-Reviewed Original ResearchConceptsLength of stayEnd-stage renal disease patientsHF admissionsRenal disease patientsHospital mortalityNonroutine dischargeHeart failureESRD patientsDisease patientsStudy periodAnnual national ratesHF admission ratesPrevalence of comorbiditiesIn-Hospital MortalityNational Inpatient SampleCost of hospitalizationAnnual percentage changeYears of ageHF hospitalizationSecondary admissionsAdmission diagnosisComorbidity prevalencePeritoneal dialysisSubgroup analysisInpatient Sample
2018
The impact of atrial fibrillation on transcatheter mitral valve repair outcomes: A propensity‐matched analysis
Subahi A, Munir A, Abubakar H, Akintoye E, Yassin A, Adegbala O, Alraies M, Elder M, Mohamad T, Kaki A, Schreiber T. The impact of atrial fibrillation on transcatheter mitral valve repair outcomes: A propensity‐matched analysis. Journal Of Interventional Cardiology 2018, 31: 925-931. PMID: 30456770, DOI: 10.1111/joic.12568.Peer-Reviewed Original ResearchConceptsTranscatheter mitral valve repairAtrial fibrillationHospital outcomesTranscatheter Mitral Valve Repair OutcomesICD-9-CM diagnostic codesMitral valve repair outcomesNational Inpatient Sample registryNon-routine hospital dischargeImpact of AFPrevalence of AFPropensity score-matched analysisHigher AF burdenPropensity-matched analysisRepresentative United States sampleHospital-level characteristicsMitral valve repairCost of hospitalizationLength of stayHospital mortalityAF burdenHospital dischargePatient characteristicsAF patientsBaseline rhythmTMVR proceduresAcute Myocardial Infarction Outcomes in Systemic Lupus Erythematosus (from the Nationwide Inpatient Sample)
Ando T, Adegbala O, Akintoye E, Ashraf S, Briasoulis A, Takagi H, Afonso L. Acute Myocardial Infarction Outcomes in Systemic Lupus Erythematosus (from the Nationwide Inpatient Sample). The American Journal Of Cardiology 2018, 123: 227-232. PMID: 30424870, DOI: 10.1016/j.amjcard.2018.09.043.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionSystemic lupus erythematosusPropensity-matched cohortMajor adverse eventsHospital mortalityTherapy ratesRevascularization strategyNSTEMI admissionsHospital outcomesAdverse eventsLupus erythematosusMyocardial infarctionOdds ratioAcute myocardial infarction (AMI) outcomesMajor adverse clinical eventsCoronary artery bypass surgeryMyocardial infarction outcomesNon-SLE cohortAcute coronary syndromeArtery bypass surgeryNationwide inpatient databaseAdverse clinical eventsElevation myocardial infarctionPercutaneous coronary interventionAcute myocardial infarctionPredictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis
Adegbala O, Olagoke O, Akintoye E, Adejumo A, Oluwole A, Jara C, Williams K, Briasoulis A, Afonso L. Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis. The American Journal Of Cardiology 2018, 123: 139-144. PMID: 30539745, DOI: 10.1016/j.amjcard.2018.09.017.Peer-Reviewed Original ResearchConceptsImpact of arrhythmiasCardiac arrhythmiasAcute myocarditisNonroutine hospital dischargePredictors of arrhythmiasPropensity-matched analysisMechanical circulatory supportSudden cardiac deathOccurrence of arrhythmiasCost of hospitalizationLength of staySignificant proportionHospital mortalityCardiogenic shockHospital outcomesHospital dischargeMyocarditis casesCardiac deathIndependent predictorsPacemaker implantationAtrial fibrillationCirculatory supportCommon arrhythmiaVentricular tachycardiaWorse outcomesClinical impact of advanced chronic kidney disease on outcomes and in-hospital complications of Takotsubo Syndrome (broken-heart-syndrome): Propensity-matched national study
Yassin A, Adegbala O, Subahi A, Abubakar H, Akintoye E, Abdelrahamn M, Ahmed A, Agarwal A, Shokr M, Pahuja M, Elder M, Kaki A, Schreiber T, Mohamad T. Clinical impact of advanced chronic kidney disease on outcomes and in-hospital complications of Takotsubo Syndrome (broken-heart-syndrome): Propensity-matched national study. International Journal Of Cardiology 2018, 277: 16-19. PMID: 30293663, DOI: 10.1016/j.ijcard.2018.09.098.Peer-Reviewed Original ResearchConceptsAdvanced chronic kidney diseaseChronic kidney diseaseAcute kidney injuryTakotsubo syndromeHospital complicationsKidney diseaseCKD groupImpact of CKDNational Inpatient Sample databasePropensity score-matched analysisAdvanced CKD groupAdvanced CKD patientsIn-Hospital MortalityCost of hospitalizationCKD patientsHospital mortalityHospital lengthHospital stayKidney injuryComplication rateInpatient mortalitySecondary outcomesTakotsubo cardiomyopathyPrimary outcomeClinical outcomesIncidence, Predictors, and In-Hospital Outcomes of Transcatheter Aortic Valve Implantation After Nonelective Admission in Comparison With Elective Admission: From the Nationwide Inpatient Sample Database
Ando T, Adegbala O, Villablanca P, Akintoye E, Ashraf S, Shokr M, Briasoulis A, Takagi H, Grines C, Afonso L, Schreiber T. Incidence, Predictors, and In-Hospital Outcomes of Transcatheter Aortic Valve Implantation After Nonelective Admission in Comparison With Elective Admission: From the Nationwide Inpatient Sample Database. The American Journal Of Cardiology 2018, 123: 100-107. PMID: 30360892, DOI: 10.1016/j.amjcard.2018.09.023.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationNationwide Inpatient Sample databaseNonelective admissionsPropensity-matched cohortAortic valve implantationHospital mortalityValve implantationElective admissionsOutcomes of TAVITransarterial transcatheter aortic valve implantationSample databaseHigher adverse outcomesPulmonary circulation disordersAcute kidney injuryHealth resource utilizationIn-Hospital OutcomesChronic kidney diseaseIndependent risk factorCongestive heart failureHigh-risk cohortAcute myocardial infarctionCardiogenic shockHospital lengthKidney injuryRespiratory failureComparison of Hospital Outcomes of Transcatheter AorticValve Implantation With Versus Without Hypothyroidism
Subahi A, Yassin A, Adegbala O, Akintoye E, Abubakar H, Elmoghrabi A, Ibrahim W, Ajam M, Pahuja M, Weinberger J, Levine D, Afonso L. Comparison of Hospital Outcomes of Transcatheter AorticValve Implantation With Versus Without Hypothyroidism. The American Journal Of Cardiology 2018, 122: 838-843. PMID: 30037424, DOI: 10.1016/j.amjcard.2018.05.025.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationHypothyroid patientsImpact of hypothyroidismHospital outcomesSevere symptomatic aortic stenosisNational Inpatient Sample databasePropensity score-matched analysisSymptomatic aortic stenosisAdditional randomized trialsAortic valve implantationCost of hospitalizationHemorrhage requiring transfusionEffect of hypothyroidismHospital mortalityTAVR outcomesHospital stayInpatient mortalityPostprocedural complicationsSecondary outcomesValve implantationAortic stenosisBlood transfusionPrimary outcomeClinical outcomesRandomized trialsClinical End Points of Transcatheter Aortic Valve Implantation Compared With Surgical Aortic Valve Replacement in Patients <65 Years of Age (From the National Inpatient Sample Database)
Ando T, Akintoye E, Holmes A, Briasoulis A, Pahuja M, Takagi H, Schreiber T, Grines C, Afonso L. Clinical End Points of Transcatheter Aortic Valve Implantation Compared With Surgical Aortic Valve Replacement in Patients <65 Years of Age (From the National Inpatient Sample Database). The American Journal Of Cardiology 2018, 122: 279-283. PMID: 29880287, DOI: 10.1016/j.amjcard.2018.03.356.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAortic ValveAortic Valve StenosisCause of DeathFemaleFollow-Up StudiesHospital MortalityHumansIncidenceInpatientsLength of StayMaleMiddle AgedPostoperative ComplicationsPropensity ScoreRegistriesRetrospective StudiesRisk AssessmentRisk FactorsSurvival RateTime FactorsTranscatheter Aortic Valve ReplacementUnited StatesYoung AdultConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationAortic valve replacementShorter hospital stayAortic valve implantationHospital mortalityHospital stayValve replacementValve implantationNational Inpatient Sample databaseSafe alternativeAcute kidney injuryOlder patient populationClinical end pointsAcute myocardial infarctionPropensity score analysisYears of agePostprocedure strokeKidney injuryValve surgeryVascular complicationsMajor complicationsPacemaker implantationPatient populationMyocardial infarctionRegional Variation in Mortality, Major Complications, and Cost After Left Ventricular Assist Device Implantation in the United States (2009 to 2014)
Briasoulis A, Inampudi C, Akintoye E, Adegbala O, Asleh R, Alvarez P, Bhama J. Regional Variation in Mortality, Major Complications, and Cost After Left Ventricular Assist Device Implantation in the United States (2009 to 2014). The American Journal Of Cardiology 2018, 121: 1575-1580. PMID: 29731117, DOI: 10.1016/j.amjcard.2018.02.047.Peer-Reviewed Original ResearchConceptsLength of stayHospital mortalityLVAD implantationMajor complicationsContinuous-flow LVAD implantationVentricular assist device implantationAssist device implantationClinical Modification codesPost-operative complicationsExtended care facilitiesNational Inpatient SampleHigher median costDiseases-Ninth RevisionPatient safety indicatorsAnnual national estimatesRisk-adjusted ratesComorbidity burdenMore patientsDevice implantationPatient populationInpatient SampleHigh percentageLVAD implantsMAIN OUTCOMEInternational ClassificationIs Transcatheter Aortic Valve Replacement Better Than Surgical Aortic Valve Replacement in Patients With Chronic Obstructive Pulmonary Disease? A Nationwide Inpatient Sample Analysis
Ando T, Adegbala O, Akintoye E, Ashraf S, Pahuja M, Briasoulis A, Takagi H, Grines C, Afonso L, Schreiber T. Is Transcatheter Aortic Valve Replacement Better Than Surgical Aortic Valve Replacement in Patients With Chronic Obstructive Pulmonary Disease? A Nationwide Inpatient Sample Analysis. Journal Of The American Heart Association 2018, 7: e008408. PMID: 29606641, PMCID: PMC5907603, DOI: 10.1161/jaha.117.008408.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisCost SavingsCost-Benefit AnalysisDatabases, FactualFemaleHealth StatusHeart Valve Prosthesis ImplantationHospital CostsHospital MortalityHumansInpatientsLength of StayMaleMiddle AgedPostoperative ComplicationsPulmonary Disease, Chronic ObstructiveRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsTranscatheter aortic valve replacementAortic valve replacementValve replacementCOPD patientsChronic obstructive pulmonary disease patientsAortic valve replacement resultsNationwide Inpatient Sample AnalysisSurgical aortic valve replacementObstructive pulmonary disease patientsChronic obstructive pulmonary diseaseNationwide Inpatient Sample databaseRespiratory-related complicationsAcute kidney injuryAcute respiratory failurePropensity-matched cohortPulmonary disease patientsNoninvasive mechanical ventilationObstructive pulmonary diseaseAcute myocardial infarctionRespiratory related complicationsHospital mortalitySAVR patientsHospital stayKidney injuryRespiratory failureFinancial Implications and Impact of Pre-existing Atrial Fibrillation on In-Hospital Outcomes in Patients Who Underwent Transcatheter Aortic Valve Implantation (from the National Inpatient Database)
Abubakar H, Yassin A, Akintoye E, Bakhit K, Pahuja M, Shokr M, Lieberman R, Afonso L. Financial Implications and Impact of Pre-existing Atrial Fibrillation on In-Hospital Outcomes in Patients Who Underwent Transcatheter Aortic Valve Implantation (from the National Inpatient Database). The American Journal Of Cardiology 2018, 121: 1587-1592. PMID: 29622287, DOI: 10.1016/j.amjcard.2018.02.052.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisArrhythmias, CardiacAtrial FibrillationCardiac Pacing, ArtificialCardiac TamponadeComorbidityDatabases, FactualFemaleHeart ArrestHeart FailureHospital CostsHospital MortalityHumansLength of StayLinear ModelsLogistic ModelsMaleMyocardial InfarctionPacemaker, ArtificialPericardial EffusionPostoperative ComplicationsPostoperative HemorrhageStrokeTranscatheter Aortic Valve ReplacementUnited StatesConceptsTranscatheter aortic valve implantationPre-existing atrial fibrillationLength of stayPeriprocedural cardiac complicationsAortic valve implantationAtrial fibrillationCost of hospitalizationCardiac complicationsHospital mortalityEnd pointValve implantationLonger hospital LOSUnderwent Transcatheter Aortic Valve ImplantationPre-existing AFHospital LOSIncidence of AFLonger LOSNationwide Inpatient Sample databaseIn-Hospital OutcomesPrimary end pointSecondary end pointsClinical end pointsHospital-level characteristicsMixed-effects logistic modelTAVI patientsTrends in Utilization, Mortality, Major Complications, and Cost After Left Ventricular Assist Device Implantation in the United States (2009 to 2014)
Briasoulis A, Inampudi C, Akintoye E, Adegbala O, Alvarez P, Bhama J. Trends in Utilization, Mortality, Major Complications, and Cost After Left Ventricular Assist Device Implantation in the United States (2009 to 2014). The American Journal Of Cardiology 2018, 121: 1214-1218. PMID: 29525059, DOI: 10.1016/j.amjcard.2018.01.041.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedCardiac TamponadeDatabases, FactualFemaleHealth Care CostsHeart FailureHeart-Assist DevicesHospital CostsHospital MortalityHumansLength of StayLogistic ModelsMaleMiddle AgedMortalityMyocardial InfarctionPatient DischargePostoperative ComplicationsPostoperative HemorrhageProsthesis ImplantationRenal DialysisRespiratory Tract DiseasesStrokeSurgical Wound DehiscenceSurgical Wound InfectionUnited StatesConceptsLength of stayMajor complicationsHospital mortalityLeft ventricular assist device (LVAD) implantsVentricular assist device implantsVentricular assist device implantationAssist device implantationHospital mortality rateNational Inpatient SampleTime of dischargeCost of hospitalizationSignificant decreaseAnnual national estimatesVentricular assist deviceHospital complicationsMajor bleedingCardiac tamponadeRespiratory complicationsAdult patientsIschemic strokePostoperative infectionCF-LVADCF-LVADsDevice implantationInpatient Sample
2017
Seasonal variation in hospitalization outcomes in patients admitted for heart failure in the United States
Akintoye E, Briasoulis A, Egbe A, Adegbala O, Alliu S, Sheikh M, Singh M, Ahmed A, Mallikethi‐Reddy S, Levine D. Seasonal variation in hospitalization outcomes in patients admitted for heart failure in the United States. Clinical Cardiology 2017, 40: 1105-1111. PMID: 28873233, PMCID: PMC6490330, DOI: 10.1002/clc.22784.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overChi-Square DistributionDatabases, FactualFemaleHeart FailureHospital CostsHospital MortalityHumansIncidenceLength of StayLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPatient AdmissionPrevalenceRisk FactorsSeasonsSex FactorsTime FactorsUnited StatesYoung AdultHospital teaching status and trascatheter aortic valve replacement outcomes in the United States: Analysis of the national inpatient sample
Telila T, Akintoye E, Ando T, Merid O, Palla M, Mallikethi‐Reddy S, Briasoulis A, Grines C, Afonso L. Hospital teaching status and trascatheter aortic valve replacement outcomes in the United States: Analysis of the national inpatient sample. Catheterization And Cardiovascular Interventions 2017, 90: 1200-1205. PMID: 28795480, DOI: 10.1002/ccd.27236.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overChi-Square DistributionDatabases, FactualFemaleHealthcare DisparitiesHospital CostsHospital MortalityHospitals, TeachingHumansLength of StayLinear ModelsLogistic ModelsMaleMultivariate AnalysisOdds RatioPostoperative ComplicationsProcess Assessment, Health CareRegistriesRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsTranscatheter aortic valve replacementAcute kidney injuryNational Inpatient SampleHospital teaching statusHospital mortalityTeaching statusInpatient SampleMechanical circulatory support devicesAortic valve replacementProcedure-related complicationsShort-term outcomesMechanical circulatory supportLength of stayCirculatory support devicesICD-9 codingHospital stayKidney injurySecondary outcomesValve replacementPrimary outcomeTAVR proceduresClinical outcomesCirculatory supportMean agePatient outcomesRegional Variation in Mortality, Length of Stay, Cost, and Discharge Disposition Among Patients Admitted for Heart Failure in the United States
Akintoye E, Briasoulis A, Egbe A, Adegbala O, Sheikh M, Singh M, Alliu S, Ahmed A, Asleh R, Kushwaha S, Levine D. Regional Variation in Mortality, Length of Stay, Cost, and Discharge Disposition Among Patients Admitted for Heart Failure in the United States. The American Journal Of Cardiology 2017, 120: 817-824. PMID: 28705376, DOI: 10.1016/j.amjcard.2017.05.058.Peer-Reviewed Original ResearchTranscatheter aortic valve implantation in the United States: Predictors of early hospital discharge
Mallikethi‐Reddy S, Akintoye E, Telila T, Sudhakar R, Jagadeesh K, Briasoulis A, Rubenfire M, Afonso L, Grines C. Transcatheter aortic valve implantation in the United States: Predictors of early hospital discharge. Journal Of Interventional Cardiology 2017, 30: 149-155. PMID: 28247569, DOI: 10.1111/joic.12373.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationEarly hospital dischargeAortic valve implantationEarly dischargeDischarge cohortPost-TAVIAortic valvuloplastyHospital dischargeBlood transfusionValve implantationPermanent pacemakerNationwide Inpatient Sample databaseMechanical circulatory support devicesAcute kidney injuryEarly discharge cohortTransfemoral TAVI approachHigher hospitalization costsMechanical circulatory supportCost of hospitalizationOverall mean ageHealthcare Utilization ProjectCirculatory support devicesHospital outcomesKidney injuryRenal failureBurden of arrhythmias in peripartum cardiomyopathy: Analysis of 9841 hospitalizations
Mallikethi-Reddy S, Akintoye E, Trehan N, Sharma S, Briasoulis A, Jagadeesh K, Rubenfire M, Grines C, Afonso L. Burden of arrhythmias in peripartum cardiomyopathy: Analysis of 9841 hospitalizations. International Journal Of Cardiology 2017, 235: 114-117. PMID: 28268089, DOI: 10.1016/j.ijcard.2017.02.084.Peer-Reviewed Original ResearchMeSH KeywordsAdultArrhythmias, CardiacCardiomyopathiesDatabases, FactualElectric CountershockElectrophysiologic Techniques, CardiacFemaleHeart ArrestHospital CostsHospital MortalityHumansLength of StayOutcome and Process Assessment, Health CarePregnancyPregnancy Complications, CardiovascularSurvival AnalysisUnited StatesConceptsBurden of arrhythmiasPeripartum cardiomyopathyHospital mortalityHospitalization costsNationwide Inpatient Sample databaseElixhauser comorbidity scoreSwan-Ganz catheterizationFrequency of arrhythmiasLength of stayHealthcare Utilization ProjectArrhythmogenic causesCardiogenic shockComorbidity scorePPM implantationBalloon pumpCoronary angiographyElectrical cardioversionCatheter ablationSignificant morbidityInpatient stayCardiac arrestCommon arrhythmiaMean agePrimary diagnosisVentricular tachycardia