2024
Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York
Anuforo A, Aneni E, Akintoye E, Anikpezie N, Patel S, Soipe A, Olojakpoke E, Burke D, Latorre J, Khandelwal P, Chaturvedi S, Ovbiagele B, Otite F. Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York. Circulation 2024, 149: 1391-1393. PMID: 38648273, DOI: 10.1161/circulationaha.123.066921.Peer-Reviewed Original Research
2023
Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation
Akintoye E, Saijo Y, Braghieri L, Badwan O, Patel H, Dabbagh M, El Dahdah J, Jellis C, Desai M, Rodriguez L, Grimm R, Griffin B, Popović Z. Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation. Journal Of The American College Of Cardiology 2023, 81: 1474-1487. PMID: 37045517, DOI: 10.1016/j.jacc.2023.02.037.Peer-Reviewed Original ResearchConceptsSmaller LV volumesAdverse eventsAortic regurgitationBody surface areaOlder patientsYounger patientsLV volumesImpact of ageLV remodelingSerial evaluationLV end-systolic volumeLV end-diastolic volumeSevere aortic regurgitationChronic aortic regurgitationLeft ventricular remodelingEnd-diastolic volumeEnd-systolic volumeLower LV volumesAdult patientsConsecutive patientsMain endpointVentricular dimensionsVentricular remodelingCurrent guidelinesPatients
2022
Clinical outcomes and 30-day readmissions associated with high-output heart failure
Uddin M, Mir T, Briasoulis A, Akintoye E, Adegbala O, Shafi I, Qureshi W, Afonso L. Clinical outcomes and 30-day readmissions associated with high-output heart failure. Hellenic Journal Of Cardiology 2022, 69: 24-30. PMID: 36273803, DOI: 10.1016/j.hjc.2022.10.004.Peer-Reviewed Original ResearchConceptsHigh-output heart failureNational Readmission DatabaseHeart failureMyelodysplastic syndromeHealthcare costsUtilization Project National Readmission DatabaseLow systemic vascular resistanceReduced ejection fractionSystemic vascular resistanceHigh cardiac outputQuality's Healthcare CostSickle cell diseaseHospital mortalityNoncardiovascular disordersUnderdiagnosed typeCardiovascular complicationsMorbid obesityVascular resistanceHematological complicationsReadmission ratesEjection fractionPulmonary diseaseClinical outcomesCardiac outputDiagnostic codesQuantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation
Akintoye E, Wang T, Nakhla M, Ali A, Fava A, Akyuz K, Popovic Z, Pettersson G, Gillinov A, Xu B, Griffin B, Desai M. Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation. JACC Cardiovascular Imaging 2022, 16: 13-24. PMID: 36274042, DOI: 10.1016/j.jcmg.2022.08.004.Peer-Reviewed Original ResearchConceptsTricuspid regurgitationMedian survival timeRisk factorsAsymptomatic patientsEchocardiographic parametersSurvival timeEarly interventionOptimal timingRight heart parametersSymptomatic tricuspid regurgitationSignificant tricuspid regurgitationFree wall strainHigh operative mortalitySex-matched cohortQuantitative echocardiographic assessmentKey prognostic markersCause mortalityOperative mortalityTR patientsEchocardiographic assessmentLate presentationPoor outcomePrognostic utilityPrognostic valuePrognostic markerClinical, functional and prognostic implications of severe atrial dilation in secondary mitral regurgitation
Layoun H, Mentias A, Akintoye E, Matta M, Kanaan C, Daou R, Ramchand J, Burns D, Gillinov A, Bhattacharya S, Puri R, Collier P, Griffin B, Kapadia S, Harb S. Clinical, functional and prognostic implications of severe atrial dilation in secondary mitral regurgitation. Open Heart 2022, 9: e001996. PMID: 35383126, PMCID: PMC8984044, DOI: 10.1136/openhrt-2022-001996.Peer-Reviewed Original ResearchConceptsSecondary mitral regurgitationAtrial dilationMitral regurgitationPrognostic implicationsSevere left atrial dilationSevere secondary mitral regurgitationLA reservoir strainLeft atrial dilationLeft ventricle dysfunctionPoor prognostic indicatorMV interventionVentricle dysfunctionMore diabetesAdult patientsTransthoracic echocardiographyEjection fractionIndependent predictorsAtrial fibrillationReservoir strainWorse prognosisPrognostic indicatorMR severityBetter outcomesFunctional alterationsPatients
2021
Changing Demographics, Temporal Trends in Waitlist, and Posttransplant Outcomes After Heart Transplantation in the United States: Analysis of the UNOS Database 1991–2019
Akintoye E, Alvarez P, Shin D, Egbe A, Panos A, Sellke F, Briasoulis A. Changing Demographics, Temporal Trends in Waitlist, and Posttransplant Outcomes After Heart Transplantation in the United States: Analysis of the UNOS Database 1991–2019. Circulation Heart Failure 2021, 14: e008764. PMID: 34689572, DOI: 10.1161/circheartfailure.121.008764.Peer-Reviewed Original ResearchConceptsHeart transplantationPosttransplant outcomesPatient characteristicsHigh-risk comorbiditiesCharacteristics of patientsShort-term survivalRisk comorbiditiesHospital strokeWaitlist mortalityRenal failureUnited NetworkTransplant volumeEra 1Organ SharingPatientsTransplantationWaitlistEra 4Study periodTime pointsSignificant decreaseTemporal trendsOutcomesSignificant changesUnited StatesPrognostic Implications of Ambulatory N-Terminal Pro-B-Type Natriuretic Peptide Changes in Patients with Continuous-Flow Left Ventricular Assist Devices
Ali A, Akintoye E, Duque E, Kshetri R, Shetty S, Sharma U, Johnson C, Panos A, Briasoulis A, Alvarez P. Prognostic Implications of Ambulatory N-Terminal Pro-B-Type Natriuretic Peptide Changes in Patients with Continuous-Flow Left Ventricular Assist Devices. ASAIO Journal 2021, 68: 524-530. PMID: 34352812, DOI: 10.1097/mat.0000000000001524.Peer-Reviewed Original ResearchConceptsNT-pro BNP concentrationHF hospitalizationBNP concentrationsVentricular assist devicePrognostic implicationsN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideAssist deviceHeart failure hospitalizationNT-pro BNPFailure hospitalizationIndex hospitalizationAdverse eventsLVAD implantationConsecutive patientsAmbulatory patientsNatriuretic peptideRetrospective studyHospitalizationAmbulatory settingPatientsMonth baselineMonthsDeathUnit increasePrognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts
Akintoye E, Afonso L, Jayanna M, Bao W, Briasoulis A, Robinson J. Prognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts. Journal Of The American Heart Association 2021, 10: e019589. PMID: 34092110, PMCID: PMC8477885, DOI: 10.1161/jaha.120.019589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmerican Heart AssociationBiomarkersCardiovascular DiseasesCholesterolClinical Decision-MakingCoronary Artery DiseaseDecision Support TechniquesDyslipidemiasFemaleHeart Disease Risk FactorsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedPractice Guidelines as TopicPredictive Value of TestsPrimary PreventionPrognosisRisk AssessmentTime FactorsUnited StatesVascular CalcificationConceptsPooled Cohort EquationsCoronary artery calcium scoreCholesterol treatment guidelinesArtery calcium scoreAtherosclerotic cardiovascular diseaseCohort EquationsRisk enhancersCalcium scoreTreatment guidelinesCardiovascular diseaseAmerican Heart Association/American CollegeAtherosclerotic cardiovascular disease eventsBackground Limited dataIntermediate-risk participantsIntermediate-risk patientsCardiovascular disease eventsLarge prospective cohortIncremental valueNet reclassification indexStatin therapyCAC testingProspective cohortPrognostic utilityC-statisticReclassification index
2020
State-Level Variation in Waitlist Mortality and Transplant Outcomes Among Patients Listed for Heart Transplantation in the US From 2011 to 2016
Akintoye E, Shin D, Alvarez P, Briasoulis A. State-Level Variation in Waitlist Mortality and Transplant Outcomes Among Patients Listed for Heart Transplantation in the US From 2011 to 2016. JAMA Network Open 2020, 3: e2028459. PMID: 33295970, PMCID: PMC7726636, DOI: 10.1001/jamanetworkopen.2020.28459.Peer-Reviewed Original ResearchConceptsHeart transplantationGraft survivalWaitlist mortalityStatus 1AAdult patientsTransplant ratesSignificant state-level variationNationwide retrospective cohort studyAdult heart transplantationOutcomes of patientsRetrospective cohort studyMultivariable-adjusted modelsOrgan Sharing databaseRate of transplantRate of deathState-level variationRisk-adjustment modelsTransplant outcomesCohort studySharing databaseMedian timeScientific RegistryUnited NetworkLowest quartileOutcome measuresCharacteristics and Outcomes of Patients Undergoing Combined Organ Transplantation (from the United Network for Organ Sharing)
Briasoulis A, Akintoye E, Kuno T, Alvarez P. Characteristics and Outcomes of Patients Undergoing Combined Organ Transplantation (from the United Network for Organ Sharing). The American Journal Of Cardiology 2020, 129: 42-45. PMID: 32540168, DOI: 10.1016/j.amjcard.2020.05.034.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanCardiomyopathy, DilatedCardiomyopathy, RestrictiveFemaleGraft RejectionHeart Defects, CongenitalHeart FailureHeart TransplantationHeart-Lung TransplantationHispanic or LatinoHumansKidney DiseasesKidney TransplantationLiver DiseasesLiver TransplantationLung DiseasesMaleMiddle AgedMortalityProportional Hazards ModelsRegistriesReoperationSurvival RateWhite PeopleConceptsHeart-liver transplantPrimary heart transplantationLong-term survivalHeart transplantationOrgan transplantsStage D heart failureD heart failureOutcomes of patientsOrgan Sharing registryLong-term outcomesCongenital heart diseaseAdult patientsMedian survivalHeart failureTransplantation ratesUnited NetworkList timeHeart diseaseOperative characteristicsOrgan transplantationSurvival analysisPatientsTransplantInverse probabilityStudy periodTrends, Outcomes, and Readmissions Among Left Ventricular Assist Device Recipients with Acute Kidney Injury Requiring Hemodialysis.
Adegbala O, Olakanmi O, Akintoye E, Inampudi C, Pahuja M, Alvarez P, Briasoulis A. Trends, Outcomes, and Readmissions Among Left Ventricular Assist Device Recipients with Acute Kidney Injury Requiring Hemodialysis. ASAIO Journal 2020, 66: 507-512. PMID: 31192850, DOI: 10.1097/mat.0000000000001036.Peer-Reviewed Original ResearchConceptsAcute kidney injuryLength of stayHospital mortalityKidney injuryLVAD recipientsMaintenance hemodialysisLVAD implantationAcute Kidney Injury Requiring HemodialysisVentricular assist device implantationVentricular assist device recipientsNational Readmission DatabaseAssist device implantationReduced hospital costsHospital outcomesPostoperative bleedingHospital dischargeRenal functionDevice implantationDevice recipientsHemodialysis therapyHospital characteristicsHospital costsHemodialysisReadmissionPatientsAortic Valve Replacement for Severe Aortic Stenosis Before and During the Era of Transcatheter Aortic Valve Implantation
Akintoye E, Ando T, Sandio A, Adegbala O, Salih M, Zubairu J, Oseni A, Sistla P, Alqasrawi M, Egbe A, Mentias A, Afonso L, Briasoulis A, Panaich S, Desai M. Aortic Valve Replacement for Severe Aortic Stenosis Before and During the Era of Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2020, 126: 73-81. PMID: 32336533, DOI: 10.1016/j.amjcard.2020.03.038.Peer-Reviewed Original ResearchConceptsSevere aortic stenosisAortic valve replacementNational Inpatient SampleTAVI eraAortic stenosisMean annual changeValve replacementFavorable short-term outcomesTranscatheter aortic valve replacementTranscatheter aortic valve implantationRate of AVRAcute kidney injuryRate of strokeAortic valve implantationShort-term outcomesRisk-adjusted ratesHospital mortalityPre-TAVIHospital outcomesKidney injuryHome dischargeHospital dischargePacemaker implantationValve implantationMedian lengthPalliative Care in Ruptured Aortic Aneurysm in the United States: A Retrospective Analysis of Nationwide Inpatient Sample Database
Ando T, Adegbala O, Uemura T, Ashraf S, Akintoye E, Pahuja M, Afonso L, Briasoulis A, Takagi H. Palliative Care in Ruptured Aortic Aneurysm in the United States: A Retrospective Analysis of Nationwide Inpatient Sample Database. Angiology 2020, 71: 633-640. PMID: 32249588, DOI: 10.1177/0003319720917239.Peer-Reviewed Original ResearchConceptsLength of stayHospitalization costsPalliative careAortic aneurysmRepair groupNationwide Inpatient Sample databasePalliative care referralPC referral ratePercutaneous repair groupRuptured Aortic AneurysmSurgical repair groupNationwide Inpatient SamplePC referralCare referralInpatient SampleReferral ratesRetrospective analysisAdmissionStudy periodSample databaseFurther studiesStayAneurysmsReferralCareRural–Urban Disparities in Intracerebral Hemorrhage Mortality in the USA: Preliminary Findings from the National Inpatient Sample
Otite F, Akano E, Akintoye E, Khandelwal P, Malik A, Chaturvedi S, Rosand J. Rural–Urban Disparities in Intracerebral Hemorrhage Mortality in the USA: Preliminary Findings from the National Inpatient Sample. Neurocritical Care 2020, 32: 715-724. PMID: 32232726, PMCID: PMC7223184, DOI: 10.1007/s12028-020-00950-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAphasiaCerebral HemorrhageComorbidityCraniotomyDeglutition DisordersFemaleHealthcare DisparitiesHospital Bed CapacityHospital MortalityHospitals, RuralHospitals, UrbanHumansHydrocephalusMaleMiddle AgedRespiration, ArtificialRisk FactorsUnited StatesYoung AdultConceptsNational Inpatient SampleSex-adjusted mortalityUrban hospitalRural hospitalsICH patientsInpatient SampleJoinpoint regressionIntracerebral hemorrhage mortalityMultivariable-adjusted modelsOdds of mortalityIntracerebral hemorrhage patientsCases of ICHHospital deathHospital mortalityMultivariable adjustmentUrban patientsRural patientsStroke careHemorrhage patientsMedicare insuranceRural-urban disparitiesPatientsResultsFrom 2004HospitalMortality gapAssociation between Hospital volume of cardiopulmonary resuscitation for in-hospital cardiac arrest and survival to Hospital discharge
Akintoye E, Adegbala O, Egbe A, Olawusi E, Afonso L, Briasoulis A. Association between Hospital volume of cardiopulmonary resuscitation for in-hospital cardiac arrest and survival to Hospital discharge. Resuscitation 2020, 148: 25-31. PMID: 31945429, DOI: 10.1016/j.resuscitation.2019.12.037.Peer-Reviewed Original ResearchConceptsNational Inpatient SampleHospital cardiac arrestHospital dischargeCase volumeCardiac arrestCases of IHCAHospital case volumeMedian case volumeNon-significant trendNon-linear associationHospital volumeHome dischargeHospital CPRYounger patientsInpatient SampleCardiopulmonary resuscitationHigh comorbidityBetter survivalFirst quartileIHCAHospitalQuartilePatientsStudy periodSurvival
2019
Palliative care referral in ST-segment elevation myocardial infarction complicated with cardiogenic shock in the United States
Ando T, Akintoye E, Uemura T, Adegbala O, Ashraf S, Pahuja M, Shokr M, Takagi H, Grines C, Afonso L, Briasoulis A. Palliative care referral in ST-segment elevation myocardial infarction complicated with cardiogenic shock in the United States. Heart & Lung 2019, 49: 25-29. PMID: 31703953, DOI: 10.1016/j.hrtlng.2019.10.005.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPalliative care referralElevation myocardial infarctionPC referralSTEMI-CSCardiogenic shockCare referralMyocardial infarctionMechanical circulatory support useCoronary artery bypass graftStudy periodPC referral rateArtery bypass graftExtended care facilitiesNationwide Inpatient SampleEdition Clinical ModificationTrends of utilizationLow-income statusPC encountersPC consultationBypass graftMultivariable analysisInpatient SampleReferral ratesHigh comorbidityGender Differences in Outcomes After Implantation of Left Ventricular Assist Devices
Ahmed A, Adegbala O, Akintoye E, Inampudi C, Ajam M, Yassin A, Olawusi E, Shokr M, Alvarez P, Briasoulis A. Gender Differences in Outcomes After Implantation of Left Ventricular Assist Devices. The Annals Of Thoracic Surgery 2019, 109: 780-786. PMID: 31479642, DOI: 10.1016/j.athoracsur.2019.07.032.Peer-Reviewed Original ResearchConceptsLVAD implantationContinuous-flow LVADVentricular assist device implantationLeft ventricular assist deviceAcute kidney injuryAssist device implantationMost common complicationsExtracorporeal membrane oxygenationMedian hospitalization costNational Inpatient SamplePostoperative cardiac tamponadeLength of stayYears of ageVentricular assist deviceGender-specific differencesHospital mortalityPostoperative thromboembolismCardiac tamponadeHospital outcomesKidney injuryPeriprocedural complicationsPostoperative sepsisCommon complicationInpatient mortalityLVAD placementLeft Ventricular Systolic Dysfunction and Cardiovascular Outcomes in Tetralogy of Fallot: Systematic Review and Meta-analysis
Egbe A, Adigun R, Anand V, West C, Montori V, Murad M, Akintoye E, Osman K, Connolly H. Left Ventricular Systolic Dysfunction and Cardiovascular Outcomes in Tetralogy of Fallot: Systematic Review and Meta-analysis. Canadian Journal Of Cardiology 2019, 35: 1784-1790. PMID: 31732195, DOI: 10.1016/j.cjca.2019.07.634.Peer-Reviewed Original ResearchConceptsCardiovascular adverse eventsLV ejection fractionLeft ventricular systolic dysfunctionLV systolic dysfunctionVentricular systolic dysfunctionSystolic dysfunctionHazard ratioLV systolic functionSudden cardiac deathNew treatment optionsClinical risk stratificationConfidence intervalsTetralogy of FallotVentricular tachycardia eventsRandom-effects modelCardiovascular outcomesAdverse eventsSystolic functionCardiac deathEjection fractionIndependent predictorsRisk stratificationPrognostic implicationsTreatment optionsTachycardia eventsClinical and economic burden of heparin-induced thrombocytopenia in hospitalized patients undergoing percutaneous peripheral arterial interventions
Subahi A, Osman M, Adegbala O, Abubakar H, Kheiri B, Yassin A, Khalid M, Akintoye E, Eljack A, Osman K, Alkhouli M. Clinical and economic burden of heparin-induced thrombocytopenia in hospitalized patients undergoing percutaneous peripheral arterial interventions. Vascular 2019, 28: 81-86. PMID: 31382836, DOI: 10.1177/1708538119868615.Peer-Reviewed Original ResearchConceptsVenous thrombosis/pulmonary embolismAcute kidney injuryKidney injuryIschemic strokePulmonary embolismHigh riskDeep venous thrombosis/pulmonary embolismPercutaneous peripheral arterial interventionsICD-9-CM codesHospital mortality differenceProlonged hospital stayHospital-level characteristicsPeripheral arterial interventionsNational Inpatient SampleHospital outcomesHospital stayIntervention patientsAbsence of heparinBaseline characteristicsHome dischargeLonger hospitalizationArterial interventionsHospitalized patientsInpatient SampleThrombocytopeniaClinical Impact of Atrial Fibrillation on Short-Term Outcomes and In-Hospital Mortality in Patients with Takotsubo Syndrome: A Propensity-Matched National Study
Yassin A, Subahi A, Adegbala O, Abubakar H, Dawdy J, Mishra T, Akintoye E, Shereef H, Ghandour M, Alhusain R, Shokr M, Oviedo C, Afonso L. Clinical Impact of Atrial Fibrillation on Short-Term Outcomes and In-Hospital Mortality in Patients with Takotsubo Syndrome: A Propensity-Matched National Study. Cardiovascular Revascularization Medicine 2019, 21: 522-526. PMID: 31439442, DOI: 10.1016/j.carrev.2019.07.022.Peer-Reviewed Original ResearchConceptsCost of hospitalizationAtrial fibrillationHospital mortalityHospital complicationsVentricular arrhythmiasNational Inpatient Sample databasePropensity score-matched analysisMajor cardiac complicationsTakotsubo syndrome patientsIn-Hospital MortalityNon-routine dischargeAtrial fibrillation groupAtrial fibrillation patientsShort-term outcomesNational Inpatient SampleLength of stayPotential confounding factorsCardiac complicationsHospital stayFibrillation groupFibrillation patientsSecondary outcomesTakotsubo syndromePrimary outcomeCardiac arrest