2022
Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation
Akintoye E, Wang T, Nakhla M, Ali A, Fava A, Akyuz K, Popovic Z, Pettersson G, Gillinov A, Xu B, Griffin B, Desai M. Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation. JACC Cardiovascular Imaging 2022, 16: 13-24. PMID: 36274042, DOI: 10.1016/j.jcmg.2022.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAgedEchocardiographyFemaleHumansMalePredictive Value of TestsRetrospective StudiesSeverity of Illness IndexTricuspid ValveTricuspid Valve InsufficiencyConceptsTricuspid regurgitationMedian survival timeRisk factorsAsymptomatic patientsEchocardiographic parametersSurvival timeEarly interventionOptimal timingRight heart parametersSymptomatic tricuspid regurgitationSignificant tricuspid regurgitationFree wall strainHigh operative mortalitySex-matched cohortQuantitative echocardiographic assessmentKey prognostic markersCause mortalityOperative mortalityTR patientsEchocardiographic assessmentLate presentationPoor outcomePrognostic utilityPrognostic valuePrognostic marker
2019
Left Ventricular Systolic Dysfunction and Cardiovascular Outcomes in Tetralogy of Fallot: Systematic Review and Meta-analysis
Egbe A, Adigun R, Anand V, West C, Montori V, Murad M, Akintoye E, Osman K, Connolly H. Left Ventricular Systolic Dysfunction and Cardiovascular Outcomes in Tetralogy of Fallot: Systematic Review and Meta-analysis. Canadian Journal Of Cardiology 2019, 35: 1784-1790. PMID: 31732195, DOI: 10.1016/j.cjca.2019.07.634.Peer-Reviewed Original ResearchConceptsCardiovascular adverse eventsLV ejection fractionLeft ventricular systolic dysfunctionLV systolic dysfunctionVentricular systolic dysfunctionSystolic dysfunctionHazard ratioLV systolic functionSudden cardiac deathNew treatment optionsClinical risk stratificationConfidence intervalsTetralogy of FallotVentricular tachycardia eventsRandom-effects modelCardiovascular outcomesAdverse eventsSystolic functionCardiac deathEjection fractionIndependent predictorsRisk stratificationPrognostic implicationsTreatment optionsTachycardia events
2017
Usefulness of the Mitral Regurgitation Severity Index to Assess the Severity of Chronic Mitral Regurgitation
Afonso L, Shokr M, Akintoye E, Briasoulis A, Alesh I, Alani A, Mahajan N, Veeranna V, Mostafa A, Zmily H, Telila T, Zalawadiya S. Usefulness of the Mitral Regurgitation Severity Index to Assess the Severity of Chronic Mitral Regurgitation. The American Journal Of Cardiology 2017, 120: 304-308. PMID: 28550931, DOI: 10.1016/j.amjcard.2017.04.027.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityChronic DiseaseEchocardiography, Doppler, ColorEchocardiography, TransesophagealFemaleFollow-Up StudiesHumansMaleMiddle AgedMitral ValveMitral Valve InsufficiencyPredictive Value of TestsReproducibility of ResultsRetrospective StudiesROC CurveSeverity of Illness IndexConceptsSevere mitral regurgitationMitral regurgitationTime-velocity integralVelocity integralNonsevere mitral regurgitationChronic mitral regurgitationInter-rater reproducibilityOptimal diagnostic accuracyDerivation cohortMitral inflowValidation cohortGood inter-rater reproducibilityHigh interobserver variabilityMR severityInter-rater agreementLevel IIMean differenceDiagnostic accuracyInterobserver variabilitySeverity IndexCut pointsRegurgitationPatientsCohortSeverity
2016
Peroral endoscopic myotomy: a meta-analysis
Akintoye E, Kumar N, Obaitan I, Alayo Q, Thompson C. Peroral endoscopic myotomy: a meta-analysis. Endoscopy 2016, 48: 1059-1068. PMID: 27617421, DOI: 10.1055/s-0042-114426.Peer-Reviewed Original ResearchMeSH KeywordsEsophageal AchalasiaEsophageal Sphincter, LowerEsophagitisGastroesophageal RefluxHumansNatural Orifice Endoscopic SurgerySeverity of Illness IndexConceptsPeroral endoscopic myotomyEfficacy of POEMLower esophageal sphincter pressureAbnormal acid exposureMean Eckardt scoreSymptomatic gastroesophageal refluxFirst-line therapyEsophageal sphincter pressureMonths of treatmentEsophageal motility disordersGastroesophageal refluxSphincter pressureBarium esophagogramClinical outcomesEckardt scoreMotility disordersEndoscopic myotomyBarium columnInvasive techniquesCurrent evidenceAcid exposureClinical successRelaxation pressureMedical literatureWarrants consideration