2017
Biochemical risk markers and 10-year incidence of atherosclerotic cardiovascular disease: independent predictors, improvement in pooled cohort equation, and risk reclassification
Akintoye E, Briasoulis A, Afonso L. Biochemical risk markers and 10-year incidence of atherosclerotic cardiovascular disease: independent predictors, improvement in pooled cohort equation, and risk reclassification. American Heart Journal 2017, 193: 95-103. PMID: 29129262, DOI: 10.1016/j.ahj.2017.08.002.Peer-Reviewed Original ResearchConceptsPooled Cohort EquationsNet reclassification indexBiochemical risk markersBiomarker scoreCohort EquationsC-statisticRisk markersTreatment decisionsPrimary atherosclerotic cardiovascular disease (ASCVD) preventionAtherosclerotic cardiovascular disease preventionCategorical net reclassification indexSensitivity C-reactive proteinCategory-free net reclassification indexN-terminal prohormoneBrain natriuretic peptideAtherosclerotic cardiovascular diseaseCardiovascular disease preventionC-reactive proteinMulti-Ethnic StudyRate of incidentsASCVD preventionIndependent predictorsNet reclassificationNatriuretic peptideRisk reclassification
2016
Novel biomarkers with potential for cardiovascular risk reclassification
Mallikethi-Reddy S, Briasoulis A, Akintoye E, Afonso L. Novel biomarkers with potential for cardiovascular risk reclassification. Biomarkers 2016, 22: 189-199. PMID: 27299923, DOI: 10.1080/1354750x.2016.1201540.Peer-Reviewed Original ResearchConceptsRed cell distribution widthCardiovascular risk reclassificationRisk reclassificationNovel risk markersCardiovascular risk predictionCell distribution widthCardiovascular riskCVD eventsMultivariate risk modelIntermediate riskAbsolute riskAsymptomatic individualsSerum biomarkersRisk markersTreatment recommendationsRisk factorsCystatin CNovel biomarkersRisk modelDistribution widthBiomarkersRisk predictionPatientsRiskReclassification