2017
Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma.
Berry JL, Xu L, Murphree AL, Krishnan S, Stachelek K, Zolfaghari E, McGovern K, Lee TC, Carlsson A, Kuhn P, Kim JW, Cobrinik D, Hicks J. Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma. JAMA Ophthalmology 2017, 135: 1221-1230. PMID: 29049475, PMCID: PMC5710399, DOI: 10.1001/jamaophthalmol.2017.4097.Peer-Reviewed Original ResearchConceptsTumor-derived DNACell-free DNARB eyesIntravitreous injectionAqueous humorAH samplesCopy number variationsSalvage therapyRB1 mutationsTumor biopsiesNumber variationsTertiary care hospitalCase series studyDNA copy number variationsDNA copy number alterationsCopy number variation profilesHigh-sensitivity kitChromosomal copy number variationsTumor DNA fractionPolymerase chain reaction primersWhole-genome sequencingPrimary enucleationCare hospitalDisease courseNumber variation profilesOptic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion
Berry JL, Zolfaghari E, Chen A, Murphree AL, Jubran R, Kim JW. Optic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion. Ocular Oncology And Pathology 2017, 3: 283-291. PMID: 29344482, PMCID: PMC5757559, DOI: 10.1159/000464468.Peer-Reviewed Original ResearchOptic nerve invasionNerve invasionAdvanced retinoblastomaOptic nervePostlaminar optic nerve invasionPoor prognostic signPostlaminar invasionSalvage therapySalvage groupPrimary enucleationGlobe salvageRetrospective reviewPrognostic signRisk factorsIntraocular tumorsHistopathologic analysisSmall cohortNervePatientsDiagnosisRetinoblastomaEyesSecond groupInvasionTreatment
2016
Risk of metastasis and orbital recurrence in advanced retinoblastoma eyes treated with systemic chemoreduction versus primary enucleation
Berry JL, Kogachi K, Aziz HA, McGovern K, Zolfaghari E, Murphree AL, Jubran R, Kim JW. Risk of metastasis and orbital recurrence in advanced retinoblastoma eyes treated with systemic chemoreduction versus primary enucleation. Pediatric Blood & Cancer 2016, 64: e26270. PMID: 28221729, PMCID: PMC7034314, DOI: 10.1002/pbc.26270.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCombined Modality TherapyEtoposideEye EnucleationFemaleFollow-Up StudiesHumansInfantMaleNeoplasm Recurrence, LocalNeoplasm StagingOrbital NeoplasmsPrognosisRetinal NeoplasmsRetinoblastomaRetrospective StudiesRisk FactorsSalvage TherapyVincristineConceptsPrimary enucleation groupSystemic chemoreductionHigh-risk pathologyMetastatic diseaseOrbital recurrencePrimary enucleationAdvanced retinoblastomaEnucleation groupTreatment failureHigh-risk pathologic featuresChildren's Hospital Los AngelesPrimary outcome measureRisk of metastasisSalvage therapySecondary enucleationRetrospective reviewE retinoblastomaMedian timePathologic featuresRetinoblastoma eyesTreatment modalitiesPoor responseOutcome measuresChemoreductionSubsequent enucleation