2024
Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes
Olfson E, Farhat L, Liu W, Vitulano L, Zai G, Lima M, Parent J, Polanczyk G, Cappi C, Kennedy J, Fernandez T. Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes. Nature Communications 2024, 15: 5870. PMID: 38997333, PMCID: PMC11245598, DOI: 10.1038/s41467-024-50247-7.Peer-Reviewed Original ResearchConceptsDNA sequencesRisk genesHigh-confidence risk genesWhole-exome DNA sequencingSequencing of familiesIdentified de novoLysine demethylase 5BDNA variantsTrio cohortBiological pathwaysGenesSequencing cohortGenetic factorsChildhood neurodevelopmental disordersAttention-deficit/hyperactivity disorderSequenceVariantsADHD riskNeurodevelopmental disordersKDM5BDNAMutationsFamilyLysineDiscovery
2023
Prevalence and gender distribution of excoriation (skin-picking) disorder: A systematic review and meta-analysis
Farhat L, Reid M, Bloch M, Olfson E. Prevalence and gender distribution of excoriation (skin-picking) disorder: A systematic review and meta-analysis. Journal Of Psychiatric Research 2023, 161: 412-418. PMID: 37023597, PMCID: PMC11137851, DOI: 10.1016/j.jpsychires.2023.03.034.Peer-Reviewed Original ResearchConceptsExcoriation disorderPublic health impactEpidemiological studiesGeneral populationSystematic reviewHealth impactsDifferent prevalence estimatesPooled prevalenceOverall prevalenceInclusion criteriaMale ratioPubMed searchPrevalence estimatesGender distributionDisordersPrevalenceDatabase searchEMBASEReviewPopulationPubMedPsycINFOStudyWomen
2022
Prevalence and gender distribution of trichotillomania: A systematic review and meta-analysis
Thomson HA, Farhat LC, Olfson E, Levine JLS, Bloch MH. Prevalence and gender distribution of trichotillomania: A systematic review and meta-analysis. Journal Of Psychiatric Research 2022, 153: 73-81. PMID: 35802953, DOI: 10.1016/j.jpsychires.2022.06.058.Peer-Reviewed Original ResearchConceptsNoticeable hair lossHair-pulling behaviorOdds ratioHair lossPrevalence estimatesSystematic reviewGender distributionSignificant public health impactMental Disorders criteriaPublic health impactMale odds ratioFemale preponderanceEpidemiological studiesPrevalence dataUnderstudied conditionDisorder criteriaStatistical ManualTrichotillomaniaEpidemiological samplePrevalenceHealth impactsConsiderable heterogeneityDatabase searchAdditional researchFemales
2016
CYP2A6 metabolism in the development of smoking behaviors in young adults
Olfson E, Bloom J, Bertelsen S, Budde JP, Breslau N, Brooks A, Culverhouse R, Chan G, Chen L, Chorlian D, Dick DM, Edenberg HJ, Hartz S, Hatsukami D, Hesselbrock VM, Johnson EO, Kramer JR, Kuperman S, Meyers JL, Nurnberger J, Porjesz B, Saccone NL, Schuckit MA, Stitzel J, Tischfield JA, Rice JP, Goate A, Bierut LJ. CYP2A6 metabolism in the development of smoking behaviors in young adults. Addiction Biology 2016, 23: 437-447. PMID: 28032407, PMCID: PMC5491369, DOI: 10.1111/adb.12477.Peer-Reviewed Original ResearchConceptsNicotine dependenceSlow metabolizersDaily smokersYoung adultsSmoking behaviorCYP2A6 variationNicotine metabolismRole of CYP2A6Adult daily smokersDevelopment of dependenceCollaborative Genetics StudyGenetics of AlcoholismSmoking milestonesCytochrome P450 2A6Young adult daily smokersNormal metabolizersCollaborative studyDaily smokingFirst cigaretteSecondary analysisCYP2A6 variantsMetabolizersYoung adulthoodP450 2A6Conflicting resultsThe significant impact of education, poverty, and race on Internet-based research participant engagement
Hartz SM, Quan T, Ibiebele A, Fisher SL, Olfson E, Salyer P, Bierut LJ. The significant impact of education, poverty, and race on Internet-based research participant engagement. Genetics In Medicine 2016, 19: 240-243. PMID: 27467456, PMCID: PMC5274598, DOI: 10.1038/gim.2016.91.Peer-Reviewed Original ResearchImplications of Personal Genomic Testing for Health Behaviors: The Case of Smoking
Olfson E, Hartz S, Carere DA, Green RC, Roberts JS, Bierut LJ, Group F. Implications of Personal Genomic Testing for Health Behaviors: The Case of Smoking. Nicotine & Tobacco Research 2016, 18: 2273-2277. PMID: 27613923, PMCID: PMC5103936, DOI: 10.1093/ntr/ntw168.Peer-Reviewed Original ResearchConceptsCurrent smokersSmoking-related diseasesPersonal genomic testingGenetic risk resultsFormer smokersGenomic testingLung cancerConsumer genomic testingGenetic riskSmoking behaviorHealth behaviorsFalse reassuranceUnhealthy behaviorsBaseline current smokersSame smoking statusConsumer personal genomic testingSmoking-related illnessesHigher quit ratesGenomic test resultsCase of smokingBehavior 6 monthsSmoking statusHeart diseaseQuit ratesGenomic testing results
2015
Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans
Olfson E, Saccone NL, Johnson EO, Chen LS, Culverhouse R, Doheny K, Foltz SM, Fox L, Gogarten SM, Hartz S, Hetrick K, Laurie CC, Marosy B, Amin N, Arnett D, Barr RG, Bartz TM, Bertelsen S, Borecki IB, Brown MR, Chasman DI, van Duijn CM, Feitosa MF, Fox ER, Franceschini N, Franco OH, Grove ML, Guo X, Hofman A, Kardia SL, Morrison AC, Musani SK, Psaty BM, Rao DC, Reiner AP, Rice K, Ridker PM, Rose LM, Schick UM, Schwander K, Uitterlinden AG, Vojinovic D, Wang JC, Ware EB, Wilson G, Yao J, Zhao W, Breslau N, Hatsukami D, Stitzel JA, Rice J, Goate A, Bierut LJ. Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. Molecular Psychiatry 2015, 21: 601-607. PMID: 26239294, PMCID: PMC4740321, DOI: 10.1038/mp.2015.105.Peer-Reviewed Original Research
2014
An ADH1B Variant and Peer Drinking in Progression to Adolescent Drinking Milestones: Evidence of a Gene‐by‐Environment Interaction
Olfson E, Edenberg HJ, Nurnberger J, Agrawal A, Bucholz KK, Almasy LA, Chorlian D, Dick DM, Hesselbrock VM, Kramer JR, Kuperman S, Porjesz B, Schuckit MA, Tischfield JA, Wang J, Wetherill L, Foroud TM, Rice J, Goate A, Bierut LJ. An ADH1B Variant and Peer Drinking in Progression to Adolescent Drinking Milestones: Evidence of a Gene‐by‐Environment Interaction. Alcohol Clinical And Experimental Research 2014, 38: 2541-2549. PMID: 25257461, PMCID: PMC4256939, DOI: 10.1111/acer.12524.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlcohol DehydrogenaseAlcohol DrinkingAlcohol-Related DisordersAlcoholismAllelesChildDisease ProgressionDrinking BehaviorFemaleGene-Environment InteractionGenetic VariationHumansLongitudinal StudiesMalePeer GroupProportional Hazards ModelsPsychological DistanceRisk FactorsSocial EnvironmentUnited StatesYoung AdultConceptsProtective effectDSM-5 symptomsFirst intoxicationImportant public health concernProportional hazards regressionAlcohol use disorder symptomsADH1B variantsDrinking milestonesAlcohol use disorderDrinking behaviorPublic health concernDiverse adult populationsAlcohol dehydrogenase 1BFinal modelPrimary outcomeHazards regressionAfrican American individualsRisk factorsUse disordersAdult populationAge 18SymptomsHealth concernIntoxicationDisorder symptoms
2012
Convergence of Genome‐Wide Association and Candidate Gene Studies for Alcoholism
Olfson E, Bierut LJ. Convergence of Genome‐Wide Association and Candidate Gene Studies for Alcoholism. Alcohol Clinical And Experimental Research 2012, 36: 2086-2094. PMID: 22978509, PMCID: PMC3521088, DOI: 10.1111/j.1530-0277.2012.01843.x.Peer-Reviewed Original Research