2021
Xenopus Tadpole Craniocardiac Imaging Using Optical Coherence Tomography.
Deniz E, Mis EK, Lane M, Khokha MK. Xenopus Tadpole Craniocardiac Imaging Using Optical Coherence Tomography. Cold Spring Harbor Protocols 2021, 2022: pdb.prot105676. PMID: 34031211, DOI: 10.1101/pdb.prot105676.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCross-Sectional StudiesInfrared RaysLarvaTomography, Optical CoherenceXenopus laevis
2018
CRISPR/Cas9 F0 Screening of Congenital Heart Disease Genes in Xenopus tropicalis
Deniz E, Mis EK, Lane M, Khokha MK. CRISPR/Cas9 F0 Screening of Congenital Heart Disease Genes in Xenopus tropicalis. Methods In Molecular Biology 2018, 1865: 163-174. PMID: 30151766, DOI: 10.1007/978-1-4939-8784-9_12.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCRISPR-Cas SystemsGenetic TestingHeart Defects, CongenitalLarvaPhenotypeRNA, Guide, CRISPR-Cas SystemsTomography, Optical CoherenceXenopusConceptsCardiac developmentCRISPR/Candidate genesHigh-density SNP arrayCRISPR/Cas9 systemGenome editing technologyCongenital heart disease genesNew genomic technologiesHeart disease genesCopy number variationsRapid functional assayXenopus tropicalisCas9 systemGenetic basisDevelopmental systemsEditing technologyGenomic technologiesSequence variationDisease genesDifferent genesGenetic analysisSNP arrayDevelopmental mechanismsMolecular mechanismsWhole-exome sequencing
2017
Visualization and quantification of injury to the ciliated epithelium using quantitative flow imaging and speckle variance optical coherence tomography
Gamm UA, Huang BK, Mis EK, Khokha MK, Choma MA. Visualization and quantification of injury to the ciliated epithelium using quantitative flow imaging and speckle variance optical coherence tomography. Scientific Reports 2017, 7: 15115. PMID: 29118359, PMCID: PMC5678121, DOI: 10.1038/s41598-017-14670-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCiliaEpitheliumMice, Inbred C57BLRegenerationRheologySkinTomography, Optical CoherenceTracheaXenopusConceptsOptical coherence tomographyCiliated epitheliumCoherence tomographyType of injuryExtent of injuryQuantification of injuryVariance optical coherence tomographyRespiratory infectionsDiffuse injuryFocal injuryImportant defense mechanismMouse tracheaInjuryMucociliary flowEpitheliumRegeneration of ciliaTomographyMultiple factorsDefense mechanismsQuantitative flowLungInfectionTracheaDisease