Seizures and Epileptiform Patterns in SAH and Their Relation to Outcomes
Maciel CB, Gilmore EJ. Seizures and Epileptiform Patterns in SAH and Their Relation to Outcomes. Journal Of Clinical Neurophysiology 2016, 33: 183-195. PMID: 27258441, DOI: 10.1097/wnp.0000000000000268.Peer-Reviewed Original ResearchConceptsSubarachnoid hemorrhageAssociation of seizuresMedication side effectsImpact of seizuresSevere subarachnoid hemorrhageRisk-benefit ratioSeizure prophylaxisAntiepileptic treatmentDifferent time pointsNeurovascular complicationsYounger patientsInterictal patternsHeterogeneous pathophysiologyNeurophysiologic monitoringSubclinical seizuresCortical irritationNew anticonvulsantsTherapeutic dosingTherapeutic approachesHigh riskSide effectsFavorable profileEpileptiform patternsSeizuresBurden quantificationUnderstanding and Managing the Ictal-Interictal Continuum in Neurocritical Care
Sivaraju A, Gilmore EJ. Understanding and Managing the Ictal-Interictal Continuum in Neurocritical Care. Current Treatment Options In Neurology 2016, 18: 8. PMID: 26874841, DOI: 10.1007/s11940-015-0391-0.Peer-Reviewed Original ResearchIctal-interictal continuumSpike-wave dischargesNeuronal injuryEEG patternsStatus epilepticusIctal-interictal continuum (IIC) patternsIntensive care unit settingClear clinical correlatePossible neuronal injuryBrain imaging findingsDepth electrode recordingsUse of anestheticsIntracranial pressure fluctuationsElectrographic improvementMultiple AEDsEnolase levelsIll patientsInterictal patternsAntiepileptic drugsElectrographic seizuresImaging findingsElectrographic patternsNeurocritical careClinical correlatesUnit setting