2024
Can Clinical Scores Predict the Presence of Hypoxic Ischemic Brain Injury on Early Head Computed Tomography After Cardiac Arrest? (P6-2.001)
Nguyen C, Molligoda B, Kim N, Kitlen E, Wira C, Perman S, Khosla A, Miller P, Greer D, Gilmore E, Beekman R. Can Clinical Scores Predict the Presence of Hypoxic Ischemic Brain Injury on Early Head Computed Tomography After Cardiac Arrest? (P6-2.001). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206255.Peer-Reviewed Original ResearchGuidelines for Seizure Prophylaxis in Adults Hospitalized with Moderate–Severe Traumatic Brain Injury: A Clinical Practice Guideline for Health Care Professionals from the Neurocritical Care Society
Frontera J, Gilmore E, Johnson E, Olson D, Rayi A, Tesoro E, Ullman J, Yuan Y, Zafar S, Rowe S. Guidelines for Seizure Prophylaxis in Adults Hospitalized with Moderate–Severe Traumatic Brain Injury: A Clinical Practice Guideline for Health Care Professionals from the Neurocritical Care Society. Neurocritical Care 2024, 40: 819-844. PMID: 38316735, DOI: 10.1007/s12028-023-01907-x.Peer-Reviewed Original ResearchModerate-severe TBITraumatic brain injuryGrading of recommendations assessmentAntiseizure medicationsResultsThe initial literature searchAdverse eventsHealth care professionalsBrain injuryClinical practice guidelinesMeta-analysis of articlesEffects of antiseizure medicationsEarly seizuresLate seizuresCare professionalsCognitive outcomesRecommendations AssessmentDuration of prophylaxisPractice guidelinesSystematic reviewProphylactic antiseizure medicationPICO 1Meta-analysisLiterature searchFunctional outcomesGrading criteria
2023
Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study
Prasad A, Gilmore E, Kim J, Begunova L, Olexa M, Beekman R, Falcone G, Matouk C, Ortega-Gutierrez S, Temkin N, Barber J, Diaz-Arrastia R, de Havenon A, Petersen N. Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study. Neurocritical Care 2023, 41: 91-99. PMID: 38158481, PMCID: PMC11285118, DOI: 10.1007/s12028-023-01896-x.Peer-Reviewed Original ResearchCerebral perfusion pressureBrain tissue hypoxiaSevere traumatic brain injuryTissue hypoxiaTraumatic brain injuryBlood pressureCerebral hypoperfusionBrain injuryAutoregulatory functionMean cerebral perfusion pressureSecondary analysisOptimal cerebral perfusion pressurePercent timeCerebral autoregulatory functionLimits of autoregulationPhase II trialArterial blood pressureBrain tissue oxygenIntracranial pressure monitoringCPP augmentationHemodynamic augmentationAutoregulatory indexII trialBP managementPerfusion pressureTemperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions
Beekman R, Khosla A, Buckley R, Honiden S, Gilmore E. Temperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions. Journal Of Intensive Care Medicine 2023, 39: 611-622. PMID: 37787185, DOI: 10.1177/08850666231203596.Peer-Reviewed Original ResearchHypoxic-ischemic brain injuryCardiac arrestPopulation-based thresholdsDuration of therapyCardiac arrest survivorsCause of deathRobust preclinical evidencePatient-centered careCritical future stepNeurologic outcomeNeuroprotective therapiesPreclinical evidenceArrest survivorsClinical equipoiseBrain injuryCurrent guidelinesFever preventionIndividualized targetOnly interventionTherapeutic windowInsufficient evidenceResearch prioritiesPersonalized approachMetabolic demandsCore temperatureClinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study
Abou Karam G, Tharmaseelan H, Aboian M, Malhotra A, Gilmore E, Falcone G, de Havenon A, Sheth K, Payabvash S. Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107375. PMID: 37738914, PMCID: PMC10591892, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107375.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleSecondary brain injuryIntracerebral hemorrhagePerihematomal edemaSubacute intracerebral hemorrhageIntravoxel incoherent motion imagingAdmission NIHSSBrain injuryMedian baseline National InstitutesPilot studyBaseline National InstitutesHealth Stroke ScalePerfusion fractionSupratentorial intracerebral hemorrhageIVIM metricsIncoherent motion imagingStroke ScaleNeuroprotective therapiesParenchymal injuryRankin ScaleRisk patientsConsecutive patientsUnivariable analysisPoor outcomeICH volume
2022
Cerebral Autoregulatory Function Before, During, and After Therapeutic Interventions Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study (S21.001)
Prasad A, Kobsa J, Soto A, Bartolome D, Begunova L, Kim J, Gilmore E, Sheth K, Matouk C, De Havenon A, Diaz-Arrastia R, Petersen N. Cerebral Autoregulatory Function Before, During, and After Therapeutic Interventions Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study (S21.001). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.557.Peer-Reviewed Original Research
2021
Low-Field, Portable Magnetic Resonance Imaging at the Bedside to Assess Brain Injury in Patients with Severe COVID-19 (1349)
Mazurek M, Yuen M, Cahn B, Rosen M, Gobeske K, Gilmore E, Hwang D, Kaddouh F, Kim J, Falcone G, Petersen N, Siner J, Spudich S, Sze G, Kimberly W, Sheth K. Low-Field, Portable Magnetic Resonance Imaging at the Bedside to Assess Brain Injury in Patients with Severe COVID-19 (1349). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.1349.Peer-Reviewed Original Research
2018
T62. Bilateral independent periodic discharges are associated with electrographic seizures and poor outcome: A case-control study
Osman G, Rahangdale R, Britton J, Gilmore E, Haider H, Hantus S, Herlopian A, Hocker S, Lee J, Legros B, Punia V, Rampal N, Szaflarski J, Wallace A, Westover M, Hirsch L, Gaspard N. T62. Bilateral independent periodic discharges are associated with electrographic seizures and poor outcome: A case-control study. Clinical Neurophysiology 2018, 129: e25-e26. DOI: 10.1016/j.clinph.2018.04.063.Peer-Reviewed Original ResearchBilateral independent periodic dischargesCase-control studyRetrospective case-control studyElectrographic seizuresBrain injuryPeriodic dischargesPoor outcomePD groupHospital mortality rateAcute brain injuryAnoxic brain injuryCNS infectionsFrequent etiologyLPD groupHemorrhagic strokeClinical correlatesWorse outcomesLevel of alertnessHigh riskBetter outcomesMortality rateControl groupMultivariate analysisSeizuresEEG patternsS96. EEG reactivity testing practices for cardiac arrest coma prognostication in North America
Amorim E, Gaspard N, Gilmore E, Hahn C, Abend N, Herman S, Hirsch L, Lee J, Cash S, Westover M. S96. EEG reactivity testing practices for cardiac arrest coma prognostication in North America. Clinical Neurophysiology 2018, 129: e178. DOI: 10.1016/j.clinph.2018.04.456.Peer-Reviewed Original ResearchEEG reactivityReactivity testingPractice patternsCritical Care EEG Monitoring Research ConsortiumHypoxic-ischemic brain injuryNorth American academic medical centersCardiac arrest prognosticationNail bed pressureEEG technologistsUnfavorable functional outcomeAcademic medical centerAmerican academic medical centersReactivity assessmentPediatric hospitalFunctional outcomeIctal dischargesBrain injuryMultiple-choice surveyMedical CenterInter-rater agreementStimulation protocolComa prognosticationAuditory stimulationStimulation modalitiesTesting protocol
2017
Ictal-Interictal Continuum: When to Worry About the Continuous Electroencephalography Pattern
Cormier J, Maciel CB, Gilmore EJ. Ictal-Interictal Continuum: When to Worry About the Continuous Electroencephalography Pattern. Seminars In Respiratory And Critical Care Medicine 2017, 38: 793-806. PMID: 29262437, DOI: 10.1055/s-0037-1607987.Peer-Reviewed Original ResearchConceptsNonconvulsive status epilepticusIctal-interictal continuumNonconvulsive seizuresEEG patternsSecondary brain injuryContinuous electroencephalography monitoringCritical care physiciansClear clinical significanceIIC patternsIll patientsStatus epilepticusCare physiciansCEEG monitoringElectroencephalography monitoringSeizure riskBrain injuryGuideline statementsClinical dilemmaClinical significanceNeuronal stressClinical approachDefinitive guidelinesElectroencephalography patternsPotential associationEarly detection
2016
Critical Care Management of Intracerebral Hemorrhage
Morawo AO, Gilmore EJ. Critical Care Management of Intracerebral Hemorrhage. Seminars In Neurology 2016, 36: 225-232. PMID: 27214697, DOI: 10.1055/s-0036-1581991.Peer-Reviewed Original ResearchConceptsManagement of ICHIntracerebral hemorrhageMedical complicationsCare managementNeurocritical care managementSecondary brain injuryCritical care managementForm of strokeRole of imagingCritical care settingSpontaneous intracerebral hemorrhageLife-sustaining therapyMajor healthcare concernRisk factorsBrain injuryClinical trialsIntracranial pressureCare settingsEarly withdrawalHemorrhageHealthcare concernComplicationsPrognosisMajor targetIntensive monitoring
2015
Clinical Correlates and Prognostic Significance of Lateralized Periodic Discharges in Patients Without Acute or Progressive Brain Injury
Sainju RK, Manganas LN, Gilmore EJ, Petroff OA, Rampal N, Hirsch LJ, Gaspard N. Clinical Correlates and Prognostic Significance of Lateralized Periodic Discharges in Patients Without Acute or Progressive Brain Injury. Journal Of Clinical Neurophysiology 2015, 32: 495-500. PMID: 26200591, DOI: 10.1097/wnp.0000000000000206.Peer-Reviewed Original ResearchConceptsProgressive brain injuryAcute brain injuryBrain injuryAbnormal consciousnessPeriodic dischargesClinical correlatesFunctional declineLateralized periodic dischargesRemote brain injuryOutcomes of patientsCase-control studyContinuous EEG monitoringHistory of epilepsyRadiologic evidenceHospital dischargeStatus epilepticusWorse prognosisAcute injuryPrognostic significanceWorse outcomesEEG monitoringMultivariate analysisInjuryPatientsLower likelihoodThe Time Course and Prognostic Values of Electroencephalographic Patterns after Anoxic Brain Injury (P7.005)
Sivaraju A, Gilmore E, Moeller J, Greer D, Hirsch L, Gaspard N. The Time Course and Prognostic Values of Electroencephalographic Patterns after Anoxic Brain Injury (P7.005). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.p7.005.Peer-Reviewed Original Research
2010
Seizures and CNS Hemorrhage
Gilmore E, Choi HA, Hirsch LJ, Claassen J. Seizures and CNS Hemorrhage. The Neurologist 2010, 16: 165-175. PMID: 20445426, DOI: 10.1097/nrl.0b013e3181c7cd0b.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageCentral nervous system hemorrhageShort-term prophylaxisNonconvulsive seizuresIntracerebral hemorrhageSpontaneous intracerebral hemorrhageSeizure prophylaxisASAH patientsAdditional injuriesAcute brain injuryPoor clinical gradeEvidence-based guidelinesCommon neurologic conditionsDeleterious effectsAntiepileptic medicationsControlled TrialsConvulsive seizuresCNS hemorrhagePoor outcomeSubarachnoid hemorrhageNeurologic conditionsSurrogate markerBrain injuryClinical gradeRecent injury