1997
The electrogenic Na/HCO3 cotransporter.
Boron W, Fong P, Hediger M, Boulpaep E, Romero M. The electrogenic Na/HCO3 cotransporter. Wiener Klinische Wochenschrift 1997, 109: 445-56. PMID: 9261985.Peer-Reviewed Original ResearchConceptsElectrogenic Na/HCO3 cotransporterProximal tubulesHCO3- cotransporterRenal proximal tubulesCO2/10 mM HCO3HCO3- transportersRegulation of intracellularBasolateral membraneNumber of tissuesNative oocytesRapid hyperpolarizationXenopus laevis oocytesExtracellular ClBicarbonate cotransporterOocyte expressionCotransporterMM HCO3OocytesCell typesMost cellsMembrane potentialAmino acid homologySingle cloneWater-injected controlsTubules
1983
Intracellular pH regulation in the renal proximal tubule of the salamander. Basolateral HCO3- transport.
Boron W, Boulpaep E. Intracellular pH regulation in the renal proximal tubule of the salamander. Basolateral HCO3- transport. The Journal Of General Physiology 1983, 81: 53-94. PMID: 6833997, PMCID: PMC2215562, DOI: 10.1085/jgp.81.1.53.Peer-Reviewed Original ResearchConceptsProximal tubulesRenal proximal tubulesRapid fallBasolateral HCO3- transportBasolateral membraneTiger salamander Ambystoma tigrinumReversible fallNominal absencePresence of HCO3Removal of ClTransient depolarizationSimilar reductionBasolateral membrane potentialSalamander Ambystoma tigrinumHCO3- transportHCO3- transportersMembrane potentialOnly minor effectsAforementioned changesTubulesCl-sensitive microelectrodesDepolarizationConstant PCO2Opposite effectAmbystoma tigrinumIntracellular pH regulation in the renal proximal tubule of the salamander. Na-H exchange.
Boron W, Boulpaep E. Intracellular pH regulation in the renal proximal tubule of the salamander. Na-H exchange. The Journal Of General Physiology 1983, 81: 29-52. PMID: 6833996, PMCID: PMC2215563, DOI: 10.1085/jgp.81.1.29.Peer-Reviewed Original ResearchConceptsProximal tubulesProximal tubule cellsRenal proximal tubulesTiger salamander Ambystoma tigrinumPH-sensitive microelectrodesFree RingerMaximal effectTubule cellsTransient riseDiuretic amilorideBasolateral sideBasolateral solutionExponential time courseSalamander Ambystoma tigrinumTime courseCl removalMaximal rateBasolateral membraneNormal rateTubulesAmbystoma tigrinumPH regulationCellsActive transportRecovery
1981
Isolated perfused salamander proximal tubule. II. Monovalent ion replacement and rheogenic transport
Sackin H, Boulpaep E. Isolated perfused salamander proximal tubule. II. Monovalent ion replacement and rheogenic transport. American Journal Of Physiology 1981, 241: f540-f555. PMID: 7304748, DOI: 10.1152/ajprenal.1981.241.5.f540.Peer-Reviewed Original Research
1980
Organic substrate effects on and heterogeneity of Necturus proximal tubule function
Forster J, Steels P, Boulpaep E. Organic substrate effects on and heterogeneity of Necturus proximal tubule function. Kidney International 1980, 17: 479-490. PMID: 6771454, DOI: 10.1038/ki.1980.56.Peer-Reviewed Original Research
1978
Segmental heterogeneity and effects of organic solutes on ion transport across the Nectums proximal tubule studied with electrophysiological techniques
Steels P, Boulpaep E. Segmental heterogeneity and effects of organic solutes on ion transport across the Nectums proximal tubule studied with electrophysiological techniques. Archives Of Physiology And Biochemistry 1978, 86: 688-689. PMID: 83844, DOI: 10.3109/13813457809055945.Peer-Reviewed Original Research
1977
The effect of organic solutes on proximal tubular fluid absorption in Necturus kidney [proceedings].
Boulpaep E, Forster J, Steels P. The effect of organic solutes on proximal tubular fluid absorption in Necturus kidney [proceedings]. Archives Of Physiology And Biochemistry 1977, 85: 623-4. PMID: 72543.Peer-Reviewed Original Research
1975
Models for coupling of salt and water transport; Proximal tubular reabsorption in Necturus kidney.
Sackin H, Boulpaep E. Models for coupling of salt and water transport; Proximal tubular reabsorption in Necturus kidney. The Journal Of General Physiology 1975, 66: 671-733. PMID: 1104761, PMCID: PMC2226230, DOI: 10.1085/jgp.66.6.671.Peer-Reviewed Original ResearchConceptsCoupling of saltWater transportDifferent boundary conditionsChemical driving forceSolvent fluxWater fluxTransport parametersBoundary conditionsGradient modelConcentration profilesOsmotic driving forceDriving forceIsotonic transportNet transportDiamondFluxTransportForceWaterFirst modelSecond modelModel
1974
Pressure Control of Sodium Reabsorption and Intercellular Backflux across Proximal Kidney Tubule
Grandchamp A, Boulpaep E. Pressure Control of Sodium Reabsorption and Intercellular Backflux across Proximal Kidney Tubule. Journal Of Clinical Investigation 1974, 54: 69-82. PMID: 4834883, PMCID: PMC301525, DOI: 10.1172/jci107751.Peer-Reviewed Original Research
1972
Effect of intraluminal pressure on proximal tubular sodium reabsorptin. A shrinking drop micropuncture study.
Grandchamp A, Boulpaep E. Effect of intraluminal pressure on proximal tubular sodium reabsorptin. A shrinking drop micropuncture study. The Yale Journal Of Biology And Medicine 1972, 45: 275-88. PMID: 4638650, PMCID: PMC2591956.Peer-Reviewed Original Research