2024
Epidemiology of cardiogenic shock using the Shock Academic Research Consortium (SHARC) consensus definitions
Berg D, Bohula E, Patel S, Alfonso C, Alviar C, Baird-Zars V, Barnett C, Barsness G, Bennett C, Chaudhry S, Fordyce C, Ghafghazi S, Gidwani U, Goldfarb M, Katz J, Menon V, Miller P, Newby L, Papolos A, Park J, Pierce M, Proudfoot A, Sinha S, Sridharan L, Thompson A, van Diepen S, Morrow D. Epidemiology of cardiogenic shock using the Shock Academic Research Consortium (SHARC) consensus definitions. European Heart Journal Acute Cardiovascular Care 2024, 13: 709-714. PMID: 39208447, PMCID: PMC11518926, DOI: 10.1093/ehjacc/zuae098.Peer-Reviewed Original ResearchCardiac intensive care unitSecondary CSConsensus definitionConcomitant cardiac arrestCritical Care Cardiology Trials NetworkRelevant to clinical practiceAcademic Research ConsortiumIn-hospital mortalityResearch ConsortiumCardiogenic shockIntensive care unitMultinational research networksCardiac arrestClinical practiceEvidence of hypoperfusionCare unitTrials NetworkTIMI Study GroupContemporary registryRegistryShock criteriaCS classificationStudy groupEpidemiologyClinical trialsOutcomes for Mechanically Ventilated Patients With Acute Myocardial Infarction Admitted to Medical vs Cardiac Intensive Care Units
Shahu A, Namburar S, Banna S, Harris A, Schenck C, Trejo-Paredes C, Thomas A, Ali T, Carnicelli A, Barnett C, Solomon M, Miller P. Outcomes for Mechanically Ventilated Patients With Acute Myocardial Infarction Admitted to Medical vs Cardiac Intensive Care Units. JACC Advances 2024, 3: 101199. PMID: 39238851, PMCID: PMC11375252, DOI: 10.1016/j.jacadv.2024.101199.Peer-Reviewed Original ResearchAcute myocardial infarctionAssociated with lower in-hospital mortalityIn-hospital mortalityLower in-hospital mortalityIntensive care unitMedical ICUPrimary diagnosis of acute myocardial infarctionMultivariable adjustmentCICU admissionInvasive mechanical ventilationVizient Clinical Data BaseBackground Acute myocardial infarctionDiagnosis of acute myocardial infarctionMultivariate logistic regressionMedical intensive care unitClinical outcomesMechanical ventilationCardiogenic shockClinical Data BaseMyocardial infarctionHospital sizeTriage of critically ill patientsMedian ventilator daysTeaching hospitalLogistic regressionEarly Serial Assessment of Aggregate Vasoactive Support and Mortality in Cardiogenic Shock: Insights From the Critical Care Cardiology Trials Network Registry
Patel S, Berg D, Bohula E, Baird-Zars V, Barsness G, Chaudhry S, Chonde M, Cooper H, Ginder C, Jentzer J, Kontos M, Miller P, Newby L, O’Brien C, Park J, Pierce M, Pisani B, Potter B, Shah K, Teuteberg J, Katz J, van Diepen S, Morrow D. Early Serial Assessment of Aggregate Vasoactive Support and Mortality in Cardiogenic Shock: Insights From the Critical Care Cardiology Trials Network Registry. Circulation Heart Failure 2024, 17: e011736. PMID: 38587438, DOI: 10.1161/circheartfailure.124.011736.Peer-Reviewed Original ResearchVasoactive-inotropic scoreCardiac intensive care unitVasoactive supportCardiogenic shockGradient of riskMechanical circulatory supportPatients admitted with CSCardiac intensive care unit admissionClinical decision-makingCritical Care Cardiology Trials NetworkIntensive care unitSCAI stagesNetwork registryCare unitTrials NetworkSOFA scoreMulticenter registryPrognostic associationMortalitySerial assessmentCirculatory supportSupportEarly changesScoresPatientsNeed for a Cardiogenic Shock Team Collaborative—Promoting a Team‐Based Model of Care to Improve Outcomes and Identify Best Practices
Senman B, Jentzer J, Barnett C, Bartos J, Berg D, Chih S, Drakos S, Dudzinski D, Elliott A, Gage A, Horowitz J, Miller P, Sinha S, Tehrani B, Yuriditsky E, Vallabhajosyula S, Katz J. Need for a Cardiogenic Shock Team Collaborative—Promoting a Team‐Based Model of Care to Improve Outcomes and Identify Best Practices. Journal Of The American Heart Association 2024, 13: e031979. PMID: 38456417, PMCID: PMC11009990, DOI: 10.1161/jaha.123.031979.Peer-Reviewed Original ResearchTeam-based models of careModels of careTeam-based modelPatient outcomesTime-sensitive conditionsCost of careTeam-based approachWell-resourced settingsEducation of stakeholdersImprove patient outcomesInfluence patient outcomesInformal careCare protocolsCardiogenic shockTeam-basedEvidence baseMultiple providersCareContemporary careTeam approachCardiac replacement therapyMultisystem organ failureSubgroup of patientsProfessional societiesProcedural proficiency
2023
Stress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction
Banna S, Schenck C, Shahu A, Thomas A, Heck C, Tangredi R, Ali T, Miller P. Stress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction. JACC Advances 2023, 3: 100750. PMID: 38939822, PMCID: PMC11198220, DOI: 10.1016/j.jacadv.2023.100750.Peer-Reviewed Original ResearchInvasive mechanical ventilationProton pump inhibitorsStress ulcer prophylaxisAcute myocardial infarctionUlcer prophylaxisVentilator-associated pneumoniaMyocardial infarctionVentilator daysST-segment elevation myocardial infarctionBackground Proton pump inhibitorsLess ventilator-associated pneumoniaVizient Clinical Data BaseObservation cohort studyProportion of patientsElevation myocardial infarctionMultivariable logistic regressionClostridium difficile infectionLower hospitalization costsClinical data baseCardiogenic shockHospital mortalityCohort studyMultivariate adjustmentHospitalization costsMechanical ventilationPrognostic significance of haemodynamic parameters in patients with cardiogenic shock
Berg D, Kaur G, Bohula E, Baird-Zars V, Alviar C, Barnett C, Barsness G, Burke J, Chaudhry S, Chonde M, Cooper H, Daniels L, Dodson M, Gerber D, Ghafghazi S, Gidwani U, Goldfarb M, Guo J, Hillerson D, Kenigsberg B, Kochar A, Kontos M, Kwon Y, Lopes M, Loriaux D, Miller P, O’Brien C, Papolos A, Patel S, Pisani B, Potter B, Prasad R, Roswell R, Shah K, Sinha S, Smith T, Solomon M, Teuteberg J, Thompson A, Zakaria S, Katz J, van Diepen S, Morrow D. Prognostic significance of haemodynamic parameters in patients with cardiogenic shock. European Heart Journal Acute Cardiovascular Care 2023, 12: 651-660. PMID: 37640029, PMCID: PMC10599641, DOI: 10.1093/ehjacc/zuad095.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitInvasive haemodynamic assessmentRight atrial pressureCardiogenic shockHaemodynamic parametersHaemodynamic assessmentCICU admissionSerum lactateCritical Care Cardiology Trials NetworkLower pulmonary artery pulsatility indexPulmonary capillary wedge pressure ratioLow systemic vascular resistancePulmonary artery pulsatility indexLower systolic blood pressureTemporary mechanical circulatory supportMedian cardiac indexTIMI Study GroupVasoactive-inotropic scoreArtery pulsatility indexEnd-organ dysfunctionRight ventricular dysfunctionSystemic vascular resistancePulmonary artery catheterSystolic blood pressureManagement of patientsExposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock
Jentzer J, Miller P, Alviar C, Yalamuri S, Bohman J, Tonna J. Exposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock. Circulation Heart Failure 2023, 16: e010328. PMID: 36871240, PMCID: PMC10121893, DOI: 10.1161/circheartfailure.122.010328.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenator supportMembrane oxygenator supportHospital mortalityCardiogenic shockVenoarterial ECMOSevere hyperoxiaMild hyperoxiaHigher PaO2Extracorporeal Life Support Organization registryHigher arterial partial pressureHours of ECMOVenoarterial ECMO supportMultivariable logistic regressionArterial partial pressureClinical trial dataAcid-base statusArterial hyperoxiaExtracorporeal CPRRegistry patientsECMO supportAirway pressureNormal PaO2Ventilatory statusClinical variablesCS patients
2022
Clinical Outcomes and Cost Associated With an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump in Patients Presenting With Acute Myocardial Infarction Complicated by Cardiogenic Shock
Miller PE, Bromfield SG, Ma Q, Crawford G, Whitney J, DeVries A, Desai NR. Clinical Outcomes and Cost Associated With an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump in Patients Presenting With Acute Myocardial Infarction Complicated by Cardiogenic Shock. JAMA Internal Medicine 2022, 182: 926-933. PMID: 35849410, PMCID: PMC9295019, DOI: 10.1001/jamainternmed.2022.2735.Peer-Reviewed Original ResearchConceptsIntra-aortic balloon pumpPercutaneous coronary interventionKidney replacement therapyAcute myocardial infarctionCardiogenic shockClinical outcomesLVAD useVentricular assist deviceBalloon pumpRetrospective propensity-matched cohort studyAssist deviceAcute Myocardial Infarction ComplicatedPropensity-matched cohort studyTotal health care costsMyocardial Infarction ComplicatedPropensity-matched analysisPropensity-matched pairsLong-term outcomesRisk of mortalityAdministrative claims dataHealth care costsIABP useIndex admissionCohort studyCoronary intervention
2020
Outcomes Associated with Respiratory Failure for Patients with Cardiogenic Shock and Acute Myocardial Infarction: A Substudy of the CULPRIT-SHOCK Trial
Giménez M, Miller PE, Alviar CL, van Diepen S, Granger CB, Montalescot G, Windecker S, Maier L, Serpytis P, Serpytis R, Oldroyd KG, Noc M, Fuernau G, Huber K, Sandri M, de Waha-Thiele S, Schneider S, Ouarrak T, Zeymer U, Desch S, Thiele H. Outcomes Associated with Respiratory Failure for Patients with Cardiogenic Shock and Acute Myocardial Infarction: A Substudy of the CULPRIT-SHOCK Trial. Journal Of Clinical Medicine 2020, 9: 860. PMID: 32245139, PMCID: PMC7141492, DOI: 10.3390/jcm9030860.Peer-Reviewed Original ResearchAcute myocardial infractionCULPRIT-SHOCK trialCardiogenic shockMechanical ventilationHigh-risk populationClinical outcomesMultivessel coronary artery diseaseSpecific high-risk populationsTriple vessel diseaseCoronary artery diseaseAcute myocardial infarctionFirst dayElevated heart rateHigher body weightMV initiationRandomized patientsRespiratory failureArtery diseaseVessel diseaseAdverse outcomesMyocardial infarctionRisk factorsOutcomes AssociatedHeart rateHigh risk
2019
Clinical Practice Patterns in Temporary Mechanical Circulatory Support for Shock in the Critical Care Cardiology Trials Network (CCCTN) Registry
Berg DD, Barnett CF, Kenigsberg BB, Papolos A, Alviar CL, Baird-Zars VM, Barsness GW, Bohula EA, Brennan J, Burke JA, Carnicelli AP, Chaudhry SP, Cremer PC, Daniels LB, DeFilippis AP, Gerber DA, Granger CB, Hollenberg S, Horowitz JM, Gladden JD, Katz JN, Keeley EC, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Miller PE, Nativi-Nicolau J, Newby LK, Park JG, Phreaner N, Roswell RO, Schulman SP, Sinha SS, Snell RJ, Solomon MA, Teuteberg JJ, Tymchak W, van Diepen S, Morrow DA. Clinical Practice Patterns in Temporary Mechanical Circulatory Support for Shock in the Critical Care Cardiology Trials Network (CCCTN) Registry. Circulation Heart Failure 2019, 12: e006635. PMID: 31707801, PMCID: PMC7008928, DOI: 10.1161/circheartfailure.119.006635.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiologistsCoronary Care UnitsExtracorporeal Membrane OxygenationFemaleHealthcare DisparitiesHeart-Assist DevicesHemodynamicsHumansIntra-Aortic Balloon PumpingMaleMiddle AgedNorth AmericaPatient AdmissionPractice Patterns, Physicians'Recovery of FunctionRisk FactorsSeverity of Illness IndexShock, CardiogenicTime FactorsTreatment OutcomeConceptsIntraaortic balloon pumpTemporary MCSCardiogenic shockIllness severityBalloon pumpPractice patternsAcute myocardial infarction-related cardiogenic shockCritical Care Cardiology Trials Network RegistryLower Sequential Organ Failure Assessment scoresSequential Organ Failure Assessment scoreTemporary mechanical circulatory support devicesVeno-arterial extracorporeal membrane oxygenationIntraaortic balloon pump useOrgan Failure Assessment scoreTemporary mechanical circulatory supportCardiac intensive care unitInfarction-related cardiogenic shockMechanical circulatory support devicesOverall practice patternsTemporary MCS devicesExtracorporeal membrane oxygenationSevere metabolic derangementHospital-level variationIntensive care unitMechanical circulatory support
2018
Positive Pressure Ventilation in the Cardiac Intensive Care Unit
Alviar CL, Miller PE, McAreavey D, Katz JN, Lee B, Moriyama B, Soble J, van Diepen S, Solomon MA, Morrow DA, Group A. Positive Pressure Ventilation in the Cardiac Intensive Care Unit. Journal Of The American College Of Cardiology 2018, 72: 1532-1553. PMID: 30236315, PMCID: PMC11032173, DOI: 10.1016/j.jacc.2018.06.074.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsContemporary cardiac intensive care unitsPositive pressure ventilationInvasive positive pressure ventilationCardiac intensive care unitIntensive care unitCare unitPressure ventilationNoninvasive positive pressure ventilationMechanical positive pressure ventilationCardiogenic pulmonary edemaProportion of patientsManagement of patientsRisk of complicationsMechanical circulatory supportComplex patient populationRight ventricular physiologyCICU mortalityCardiogenic shockRespiratory failurePulmonary edemaCirculatory supportCardiac arrestPatient populationVentricular physiologyMedical complexity
2017
Advanced Percutaneous Mechanical Circulatory Support Devices for Cardiogenic Shock
Miller PE, Solomon MA, McAreavey D. Advanced Percutaneous Mechanical Circulatory Support Devices for Cardiogenic Shock. Critical Care Medicine 2017, 45: 1922-1929. PMID: 28857849, PMCID: PMC5640487, DOI: 10.1097/ccm.0000000000002676.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPercutaneous mechanical circulatory supportPercutaneous mechanical circulatory support devicesMechanical circulatory supportMechanical circulatory support devicesCirculatory support devicesCardiogenic shockExtracorporeal membrane oxygenationCirculatory supportMembrane oxygenationSupport devicesIntra-aortic balloon pump counterpulsationVeno-arterial extracorporeal membrane oxygenationIntra-aortic balloon pumpGreater hemodynamic supportEarly coronary revascularizationSignificant vascular complicationsOngoing prospective studyBiventricular circulatory supportCoronary revascularizationHemodynamic supportStrength of associationVascular complicationsBalloon pumpComplication rateProspective study