2020
Glycemic Variability and CNS Inflammation: Reviewing the Connection
Watt C, Sanchez-Rangel E, Hwang JJ. Glycemic Variability and CNS Inflammation: Reviewing the Connection. Nutrients 2020, 12: 3906. PMID: 33371247, PMCID: PMC7766608, DOI: 10.3390/nu12123906.Peer-Reviewed Original ResearchConceptsBlood-brain barrierGlycemic variabilityOxidative stressCentral nervous system outcomesImpact of hyperglycemiaType 2 diabetesCNS inflammationVascular complicationsVascular inflammationCognitive dysfunctionTherapeutic implicationsCognitive deficitsType 1Brain functionNeuroinflammationInflammationDysfunctionGlucoseLow levelsSystem outcomesHigh levelsComplicationsHyperglycemiaDiabetesLatest data
2018
Glycemic Variability and Brain Glucose Levels in T1DM
Hwang JJ, Jiang L, Sanchez Rangel E, Fan X, Ding Y, Lam W, Leventhal J, Dai F, Rothman DL, Mason GF, Sherwin RS. Glycemic Variability and Brain Glucose Levels in T1DM. Diabetes 2018, 68: db180722. PMID: 30327383, PMCID: PMC6302539, DOI: 10.2337/db18-0722.Peer-Reviewed Original ResearchConceptsBrain glucose levelsGlycemic variabilityGlucose levelsHyperglycemic clampType 1 diabetes mellitusPlasma glucose levelsBrain glucose transportHealthy control participantsDiabetes mellitusBrain glucoseControl ratsContinuous glucose monitorGlucose clampRat modelOccipital lobeMRS scanningT1DMGlucose kineticsControl participantsGlucose transport kineticsGlucose monitorSimilar changesRatsClampGlucose transport