Metformin: clinical use in type 2 diabetes
Sanchez-Rangel E, Inzucchi SE. Metformin: clinical use in type 2 diabetes. Diabetologia 2017, 60: 1586-1593. PMID: 28770321, DOI: 10.1007/s00125-017-4336-x.Peer-Reviewed Original ResearchConceptsGlucose-lowering effectType 2 diabetesModerate chronic kidney diseaseOral glucose-lowering medicationsNew glucose-lowering drugsType 2 diabetes mellitusOptimal initial therapyGlucose-lowering medicationsChronic kidney diseaseFirst-line treatmentGlucose-lowering drugsGood safety profilePrecise mechanismHepatic glucose productionMore robust evidenceFoundation therapyInitial therapyCardiovascular eventsInflammatory markersRenal dysfunctionDiabetes mellitusWeight neutralityKidney diseaseSafety profileGlucose production