2024
The association between salivary oxytocin, age, and puberty in children with and without OCD
Mora-Jensen A, Clemmensen L, Grønberg M, Lebowitz E, Quintana D, Jørgensen N, Larsen C, Bak L, Christensen G, Pretzmann L, Uhre V, Christensen S, Uhre C, Korsbjerg N, Thoustrup C, Hagstrøm J, Ritter M, Plessen K, Pagsberg A, Lønfeldt N. The association between salivary oxytocin, age, and puberty in children with and without OCD. Scientific Reports 2024, 14: 28693. PMID: 39562644, PMCID: PMC11576962, DOI: 10.1038/s41598-024-80194-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderOxytocin concentrationsPediatric obsessive-compulsive disorderSalivary oxytocin concentrationsVisual inspection of plotsOxytocin systemPsychiatric disordersSalivary oxytocinEnzyme-linked immunosorbent assayBehavioral changesPubertal stageAdolescentsModerate supportOxytocinInconsistent resultsPost-hocDisordersChildrenPost hoc testSystem activityCovariates ageParentsAssociationImmunosorbent assayHypothesis
2018
Negative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth
Lebowitz ER, Blumberg HP, Silverman WK. Negative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth. Journal Of Affective Disorders 2018, 245: 806-811. PMID: 30699863, PMCID: PMC6361537, DOI: 10.1016/j.jad.2018.11.070.Peer-Reviewed Original ResearchConceptsNegative peer interactionsPeer social interactionSalivary oxytocin levelsAnxious youthPeer interactionsHigher oxytocin levelsAnxiety disordersOxytocin levelsSocial interactionSuicidal ideationSocial eventsSelf-report measuresPrimary anxiety disorderSemi-structured diagnostic interviewNegative social interactionsPeripheral oxytocin levelsSample of childrenPeer victimization
2017
Oxytocin response to youth–mother interactions in clinically anxious youth is associated with separation anxiety and dyadic behavior
Lebowitz ER, Silverman WK, Martino AM, Zagoory‐Sharon O, Feldman R, Leckman JF. Oxytocin response to youth–mother interactions in clinically anxious youth is associated with separation anxiety and dyadic behavior. Depression And Anxiety 2017, 34: 127-136. PMID: 28052452, PMCID: PMC5503301, DOI: 10.1002/da.22585.Peer-Reviewed Original ResearchConceptsSeparation anxiety disorderAnxious youthAnxiety disordersSeparation anxietySalivary oxytocinAffective touchDSM-5 anxiety disordersYouth anxiety symptomsOT responseParticular anxiety disordersAttachment figuresReliable codersMaternal sensitivityDyadic behaviorsChildren's ratingsMaternal intrusivenessAttachment behaviorAnxiety symptomsAnxiety regulationSocial supportPossible intervention strategiesSignificant distressHigher youthYouthIntervention strategies
2015
Salivary oxytocin in clinically anxious youth: Associations with separation anxiety and family accommodation
Lebowitz ER, Leckman JF, Feldman R, Zagoory-Sharon O, McDonald N, Silverman WK. Salivary oxytocin in clinically anxious youth: Associations with separation anxiety and family accommodation. Psychoneuroendocrinology 2015, 65: 35-43. PMID: 26716876, PMCID: PMC4895196, DOI: 10.1016/j.psyneuen.2015.12.007.Peer-Reviewed Original ResearchConceptsSalivary OT levelsFamily accommodationSeparation anxiety disorderYouth anxietyAnxiety disordersAnxious youthInterpersonal behaviorSeparation anxietyOT levelsDSM-5 anxiety disordersSeparation anxiety symptomsTreatment of anxietyNeuropeptide oxytocinSalivary OTClinical anxietyMaternal ratingsSalivary oxytocinAnxiety symptomsOxytocinergic systemRegulation of anxietyAnxious behaviorOwn behaviorAnxiety assessmentAnxietyParental involvement