2021
Cytokine Signaling and Matrix Remodeling Pathways Associated with Cardiac Sarcoidosis Disease Activity Defined Using FDG PET Imaging
Young BD, Moreland H, Oatmen KE, Freeburg LA, Shahab Z, Herzog E, Miller EJ, Spinale FG. Cytokine Signaling and Matrix Remodeling Pathways Associated with Cardiac Sarcoidosis Disease Activity Defined Using FDG PET Imaging. International Heart Journal 2021, 62: 21-164. PMID: 34544982, DOI: 10.1536/ihj.21-164.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCase-Control StudiesCytokinesEvaluation Studies as TopicFemaleFluorodeoxyglucose F18Heart DiseasesHumansImmunosuppressive AgentsInflammationMaleMatrix Metalloproteinase InhibitorsMatrix MetalloproteinasesMiddle AgedPositron-Emission TomographyProspective StudiesRadiopharmaceuticalsReceptors, Interleukin-2Receptors, Tumor Necrosis FactorRisk AssessmentSarcoidosisSeverity of Illness IndexTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AConceptsTumor necrosis factorSoluble cytokine receptorsCardiac sarcoidosisCS patientsMatrix metalloproteinasePlasma MMP-9 levelsFluorodeoxyglucose positron emission tomographyPlasma tumor necrosis factorAnti-inflammatory regimensBiopsy-confirmed sarcoidosisReferent control valuesSarcoidosis disease activityVascular endothelial growth factor receptorHeart failure therapySoluble TNF receptorsEndothelial growth factor receptorMMP-9 levelsSpecific inflammatory pathwaysFDG-PET imagingEndogenous MMP inhibitorsCytokine receptorsPositron emission tomographyCytokine receptor profilesGrowth factor receptorSIL-2R
2020
Survival Following Implantable Cardioverter‐Defibrillator Implantation in Patients With Amyloid Cardiomyopathy
Higgins AY, Annapureddy AR, Wang Y, Minges KE, Lampert R, Rosenfeld LE, Jacoby DL, Curtis JP, Miller EJ, Freeman JV. Survival Following Implantable Cardioverter‐Defibrillator Implantation in Patients With Amyloid Cardiomyopathy. Journal Of The American Heart Association 2020, 9: e016038. PMID: 32867553, PMCID: PMC7726970, DOI: 10.1161/jaha.120.016038.Peer-Reviewed Original ResearchConceptsImplantable cardioverter defibrillator implantationCardioverter-defibrillator implantationNonischemic cardiomyopathyCardiac amyloidosisDiabetes mellitusCerebrovascular diseaseVentricular tachycardiaMultivariable Cox proportional hazards regression modelsCox proportional hazards regression modelProportional hazards regression modelsKaplan-Meier survival curvesCox proportional hazards modelPropensity-matched cohortOutcomes of patientsHazards regression modelsProportional hazards modelCause mortalityICD implantationRenal functionMultivariable analysisConclusions MortalityRisk factorsRegistry dataAmyloid cardiomyopathyHigh risk