The Impact of Active Ascertainment on Sex-Specific Differences in the Prevalence and Phenotype of Transthyretin Cardiac Amyloidosis: The SCAN-MP Study
Chan N, Einstein A, Teruya S, Rodriguez C, Helmke S, Cuomo M, Santana D, Castillo M, Smiley D, Sabogal N, Lamour S, Winburn M, Fine D, de Freitas C, Kattan C, Miller E, Maurer M, Ruberg F. The Impact of Active Ascertainment on Sex-Specific Differences in the Prevalence and Phenotype of Transthyretin Cardiac Amyloidosis: The SCAN-MP Study. The American Journal Of Cardiology 2024 PMID: 39581521, DOI: 10.1016/j.amjcard.2024.11.019.Peer-Reviewed Original ResearchATTR-CATransthyretin cardiac amyloidosisProportion of womenCardiac amyloidosisReferral cohortLower left ventricular mass indexHigher left ventricular ejection fractionPrevalence of ATTR-CAATTR-CA patientsWild-type diseaseVentricular ejection fractionVentricular mass indexPosterior wall thicknessAscertainment cohortLeft ventricular hypertrophyReduce sex disparitiesHigher proportion of womenATTRwt-CAEjection fractionEchocardiographic evidenceHeart failureMass indexSex-specific differencesSevere phenotypeSex distributionValidation Of The Transthyretin Amyloidosis Cardiomyopathy Score In A Black And Hispanic Screening Population: An Interim Analysis Of The First 342 Cases From The Scan-mp Study
Chan N, Einstein A, Teruya S, Rodriguez C, Helmke S, Cuomo M, DeLuca A, Johnson L, Kinkhabwala M, Santana D, Castillo M, Smiley D, Sabogal N, Lamour S, Winburn M, Fine D, De Freitas C, Kattan C, Miller E, Ruberg F, Maurer M. Validation Of The Transthyretin Amyloidosis Cardiomyopathy Score In A Black And Hispanic Screening Population: An Interim Analysis Of The First 342 Cases From The Scan-mp Study. Journal Of Cardiac Failure 2024, 30: 166-167. DOI: 10.1016/j.cardfail.2023.10.122.Peer-Reviewed Original ResearchPosterior wall thicknessRelative wall thicknessATTR-CMEjection fractionCardiomyopathy scoresMayo ClinicNuclear scintigraphyGreater posterior wall thicknessLogistic regressionElevated filling pressuresHigher cardiac biomarkersLarger atrial volumesWorse renal functionLow ejection fractionHigh-risk patientsROC curveHosmer-Lemeshow testReliable clinical toolNegative predictive valueBinary logistic regressionClinical characteristicsRenal functionAtrial volumeHeart failureImpaired relaxation