2024
The Impact of Active Ascertainment on Sex-Specific Differences in the Prevalence and Phenotype of Transthyretin Cardiac Amyloidosis: The SCAN-MP Study
Chan N, Einstein A, Teruya S, Rodriguez C, Helmke S, Cuomo M, Santana D, Castillo M, Smiley D, Sabogal N, Lamour S, Winburn M, Fine D, de Freitas C, Kattan C, Miller E, Maurer M, Ruberg F. The Impact of Active Ascertainment on Sex-Specific Differences in the Prevalence and Phenotype of Transthyretin Cardiac Amyloidosis: The SCAN-MP Study. The American Journal Of Cardiology 2024 PMID: 39581521, DOI: 10.1016/j.amjcard.2024.11.019.Peer-Reviewed Original ResearchATTR-CATransthyretin cardiac amyloidosisProportion of womenCardiac amyloidosisReferral cohortLower left ventricular mass indexHigher left ventricular ejection fractionPrevalence of ATTR-CAATTR-CA patientsWild-type diseaseVentricular ejection fractionVentricular mass indexPosterior wall thicknessAscertainment cohortLeft ventricular hypertrophyReduce sex disparitiesHigher proportion of womenATTRwt-CAEjection fractionEchocardiographic evidenceHeart failureMass indexSex-specific differencesSevere phenotypeSex distributionArtificial Intelligence Predicts Hospitalization for Acute Heart Failure Exacerbation in Patients Undergoing Myocardial Perfusion Imaging
Feher A, Bednarski B, Miller R, Shanbhag A, Lemley M, Miras L, Sinusas A, Miller E, Slomka P. Artificial Intelligence Predicts Hospitalization for Acute Heart Failure Exacerbation in Patients Undergoing Myocardial Perfusion Imaging. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266761. PMID: 38548351, PMCID: PMC11064832, DOI: 10.2967/jnumed.123.266761.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingHF hospitalizationHeart failureStress left ventricular ejection fractionPerfusion imagingHF exacerbationPredictive of HF hospitalizationsSPECT/CT myocardial perfusion imagingMyocardial perfusionInternational cohortAcute heart failure exacerbationMedian follow-upVentricular ejection fractionReceiver-operating-characteristic curveClinical risk factorsHeart failure exacerbationExternal validation cohortAcute HF exacerbationPrevent HF hospitalizationsImaging parametersCalcium scoreEjection fractionClinical parametersCT scanValidation cohortValidation Of The Transthyretin Amyloidosis Cardiomyopathy Score In A Black And Hispanic Screening Population: An Interim Analysis Of The First 342 Cases From The Scan-mp Study
Chan N, Einstein A, Teruya S, Rodriguez C, Helmke S, Cuomo M, DeLuca A, Johnson L, Kinkhabwala M, Santana D, Castillo M, Smiley D, Sabogal N, Lamour S, Winburn M, Fine D, De Freitas C, Kattan C, Miller E, Ruberg F, Maurer M. Validation Of The Transthyretin Amyloidosis Cardiomyopathy Score In A Black And Hispanic Screening Population: An Interim Analysis Of The First 342 Cases From The Scan-mp Study. Journal Of Cardiac Failure 2024, 30: 166-167. DOI: 10.1016/j.cardfail.2023.10.122.Peer-Reviewed Original ResearchPosterior wall thicknessRelative wall thicknessATTR-CMEjection fractionCardiomyopathy scoresMayo ClinicNuclear scintigraphyGreater posterior wall thicknessLogistic regressionElevated filling pressuresHigher cardiac biomarkersLarger atrial volumesWorse renal functionLow ejection fractionHigh-risk patientsROC curveHosmer-Lemeshow testReliable clinical toolNegative predictive valueBinary logistic regressionClinical characteristicsRenal functionAtrial volumeHeart failureImpaired relaxation
2023
Detection of Left Ventricular Systolic Dysfunction From Electrocardiographic Images
Sangha V, Nargesi A, Dhingra L, Khunte A, Mortazavi B, Ribeiro A, Banina E, Adeola O, Garg N, Brandt C, Miller E, Ribeiro A, Velazquez E, Giatti L, Barreto S, Foppa M, Yuan N, Ouyang D, Krumholz H, Khera R. Detection of Left Ventricular Systolic Dysfunction From Electrocardiographic Images. Circulation 2023, 148: 765-777. PMID: 37489538, PMCID: PMC10982757, DOI: 10.1161/circulationaha.122.062646.Peer-Reviewed Original ResearchConceptsLV systolic dysfunctionYale-New Haven HospitalVentricular systolic dysfunctionSystolic dysfunctionLV ejection fractionBrazilian Longitudinal StudyNew Haven HospitalEjection fractionCardiology clinicRegional hospitalLeft ventricular systolic dysfunctionCedars-Sinai Medical CenterAdult Health (ELSA-Brasil) cohortThe Association Between Body Mass Index And Functional Status In Minority Patients With Heart Failure With Preserved Ejection Fraction: The SCAN-MP Study
Driggin E, Rosenblum H, Teruya S, Rodriguez C, Kurian D, Raiszadeh F, Fine D, Sabogal N, Edmiston J, Massillon D, Winburn M, Miller E, Ruberg F, Maurer M. The Association Between Body Mass Index And Functional Status In Minority Patients With Heart Failure With Preserved Ejection Fraction: The SCAN-MP Study. Journal Of Cardiac Failure 2023, 29: 668-669. DOI: 10.1016/j.cardfail.2022.10.299.Peer-Reviewed Original ResearchBody mass indexKCCQ overall summary scoreExcess fat massFunctional statusOverall summary scoreObesity statusQuality of lifeMinority patientsFunctional capacityObese patientsEjection fractionHeart failureIndependent predictorsMass indexSPPB scoreFat massCardiac amyloidosisSummary scoresMuscle massShort Physical Performance Battery scoreFirst heart failure hospitalizationMedian body mass indexPhysical Performance Battery scoreHigher body mass indexWorse SPPB scoreImpaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis
Feher A, Miller E, Peters D, Mojibian H, Sinusas A, Hinchcliff M, Baldassarre L. Impaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis. Rheumatology International 2023, 43: 849-858. PMID: 36894756, DOI: 10.1007/s00296-023-05294-6.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementLV-GLSSystemic sclerosisWorse survivalClinical indicationsImpaired left ventricular global longitudinal strainLeft ventricular global longitudinal strainPresence of LGECMR strainLV cardiac indexWorse LV-GLSLV ejection fractionCox regression analysisGlobal longitudinal strainLV cardiac outputGlobal radialCardiac indexOverall survivalRetrospective cohortEjection fractionPrognostic valueAdverse outcomesCardiac outputGadolinium enhancementRV strain
2022
Differences in Prognostic Value of Myocardial Perfusion Single-Photon Emission Computed Tomography Using High-Efficiency Solid-State Detector Between Men and Women in a Large International Multicenter Study
Tamarappoo BK, Otaki Y, Sharir T, Hu LH, Gransar H, Einstein AJ, Fish MB, Ruddy TD, Kaufmann P, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Eisenberg E, Liang JX, Dey D, Berman DS, Slomka PJ. Differences in Prognostic Value of Myocardial Perfusion Single-Photon Emission Computed Tomography Using High-Efficiency Solid-State Detector Between Men and Women in a Large International Multicenter Study. Circulation Cardiovascular Imaging 2022, 15: e012741. PMID: 35727872, PMCID: PMC9307118, DOI: 10.1161/circimaging.121.012741.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsTotal perfusion defectPrognostic valuePerfusion defectsSingle photon emissionLarge international multicenter studyMyocardial perfusion single-photon emissionPerfusion single-photon emissionStress SPECT myocardial perfusion imagingSPECT myocardial perfusion imagingAdverse cardiac eventsMACE-free survivalMultivariable Cox modelSingle-center studyGreater prognostic valueInternational multicenter studyProportional hazards modelMyocardial perfusion defectsMyocardial perfusion imagingREFINE SPECT registryConventional single-photon emissionCardiac eventsHazard ratioEjection fractionMulticenter study
2021
Prognostic Value of Phase Analysis for Predicting Adverse Cardiac Events Beyond Conventional Single-Photon Emission Computed Tomography Variables: Results From the REFINE SPECT Registry
Kuronuma K, Miller RJH, Otaki Y, Van Kriekinge SD, Diniz MA, Sharir T, Hu LH, Gransar H, Liang JX, Parekh T, Kavanagh PB, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Tamarappoo BK, Dey D, Berman DS, Slomka PJ. Prognostic Value of Phase Analysis for Predicting Adverse Cardiac Events Beyond Conventional Single-Photon Emission Computed Tomography Variables: Results From the REFINE SPECT Registry. Circulation Cardiovascular Imaging 2021, 14: e012386. PMID: 34281372, PMCID: PMC8978932, DOI: 10.1161/circimaging.120.012386.Peer-Reviewed Original ResearchMeSH KeywordsAgedCanadaCoronary CirculationDisease ProgressionFemaleHumansIncidenceIsraelMaleMiddle AgedMyocardial IschemiaMyocardial Perfusion ImagingPredictive Value of TestsPrognosisRegistriesRisk AssessmentRisk FactorsStroke VolumeTomography, Emission-Computed, Single-PhotonUnited StatesVentricular Function, LeftConceptsMajor adverse cardiac eventsVentricular ejection fractionTotal perfusion deficitSingle photon emissionAdverse cardiac eventsEjection fractionPerfusion deficitsCardiac eventsPrognostic valueTomography myocardial perfusion imagingVentricular ejection fraction assessmentHighest decile groupProportional hazards analysisTomography myocardial perfusionIndependent prognostic significanceIndependent prognostic valueLarge multinational registryEjection fraction assessmentMyocardial perfusion imagingREFINE SPECT registryAdditional radiation exposureConventional single-photon emissionMACE riskMACE rateMultinational registry
2018
New Method for Quantification of the Left Ventricular Function from Low-dose Equilibrium Radionuclide Angiocardiography: Comparisons with Conventional Methods in Patients
Liu Y, Tsatkin V, Fazzone-Chettiar R, Miller E, Sinusas A. New Method for Quantification of the Left Ventricular Function from Low-dose Equilibrium Radionuclide Angiocardiography: Comparisons with Conventional Methods in Patients. 2018, 00: 1-3. DOI: 10.1109/nssmic.2018.8824749.Peer-Reviewed Original ResearchEnd-diastolic volumeEquilibrium radionuclide angiocardiographyLeft ventricular functionGated blood pool SPECTPeak filling rateBlood pool SPECTEjection fractionVentricular functionRadionuclide angiocardiographyLV end-diastolic volumeHigh-dose injectionLow-dose injectionsAnterior oblique viewSingle photon emissionRed blood cellsDose reductionReduced radiation dosePatientsShort-axis slicesBlood cellsRadiation exposureGold standardImaging modalitiesRadiation doseOblique viewIn Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents
Boutagy NE, Wu J, Cai Z, Zhang W, Booth CJ, Kyriakides TC, Pfau D, Mulnix T, Liu Z, Miller EJ, Young LH, Carson RE, Huang Y, Liu C, Sinusas AJ. In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents. JACC Basic To Translational Science 2018, 3: 378-390. PMID: 30062224, PMCID: PMC6058999, DOI: 10.1016/j.jacbts.2018.02.003.Peer-Reviewed Original ResearchLeft ventricular ejection fractionSuperoxide productionReactive oxygen speciesMarkers of ROSNovel positron emission tomography (PET) tracerEarly detectionMyocardial superoxide productionVentricular ejection fractionDoxorubicin-induced cardiotoxicityCardiac superoxide productionPositron emission tomography (PET) tracerPositron emission tomographyEmission tomography tracerEjection fractionCancer patientsCardiotoxicity detectionEmission tomographyTomography tracerCardiotoxicityReactive oxygen species (ROS) detectionWeeksOxygen speciesRodentsEchocardiographyPatients
2017
Up-regulation of Intracellular Calcium Handling Underlies the Recovery of Endotoxemic Cardiomyopathy in Mice
Morse JC, Huang J, Khona N, Miller EJ, Siwik DA, Colucci WS, Hobai IA. Up-regulation of Intracellular Calcium Handling Underlies the Recovery of Endotoxemic Cardiomyopathy in Mice. Anesthesiology 2017, 126: 1125-1138. PMID: 28410273, DOI: 10.1097/aln.0000000000001627.Peer-Reviewed Original ResearchConceptsCalcium transientsCardiac recoveryLipopolysaccharide challengeCalcium handlingDay 3Sarcomere shorteningCardiomyocyte calcium handlingSepsis-induced cardiomyopathyVentricular ejection fractionIntracellular calcium handlingSarcoplasmic reticulum calcium loadMale C57BL/6 miceSodium/calcium exchangeMyocardial protein expressionSarcoplasmic reticulum calcium pumpSystemic inflammationEjection fractionEndotoxemic miceC57BL/6 miceMyocardial mechanismsCardiac functionCalcium loadCardiac contractilityBaseline levelsDay 6
2016
Multicenter Study of Planar Technetium 99m Pyrophosphate Cardiac Imaging: Predicting Survival for Patients With ATTR Cardiac Amyloidosis
Castano A, Haq M, Narotsky DL, Goldsmith J, Weinberg RL, Morgenstern R, Pozniakoff T, Ruberg FL, Miller EJ, Berk JL, Dispenzieri A, Grogan M, Johnson G, Bokhari S, Maurer MS. Multicenter Study of Planar Technetium 99m Pyrophosphate Cardiac Imaging: Predicting Survival for Patients With ATTR Cardiac Amyloidosis. JAMA Cardiology 2016, 1: 880-889. PMID: 27557400, DOI: 10.1001/jamacardio.2016.2839.Peer-Reviewed Original ResearchConceptsATTR cardiac amyloidosisCardiac amyloidosisMulticenter studyWorse survivalEjection fractionHeart failureCardiac imagingMultivariable Cox proportional hazards regression analysisCox proportional hazards regression analysisProportional hazards regression analysisRetrospective cohort studyHigh clinical suspicionSingle-center studyHazards regression analysisKaplan-Meier analysisAL cardiac amyloidosisDifferentiation of patientsTransthyretin cardiac amyloidosisDates of analysisSemiquantitative visual scoreContralateral chestPlanar technetiumClinical suspicionCohort studyPrognostic importance